Squamous cell carcinoma of maxillary sinus: a comparison of clinico-radiological staging with pre-operative staging


  • C. P. Sudheer Department of ENT, MNR Medical College and Hospital, Sangareddy, Telangana, India
  • T. Dinesh Singh Department of ENT, Mallareddy institute of medical sciences, Suraram, Hyderabad, Telangana, India




Paranasal air sinus, Maxillary sinus malignancy, Clinical staging, Radiological staging, prognosis


Background: The nasal cavity and paranasal sinuses are the site of origin of more complex, histologically diverse group of tumors which include neoplasms derived from mucosal epithelium, seromucinous glands and haematolymphoid cells. This study aimed to assess the incidence and prognosis of maxillary sinus malignancy.

Methods: A total 25 (16 males, 09 females) malignancy cases between age group 11-70 years. All the cases were undergone with detailed clinical examination. The TNM staging system was followed to detect and standardize the disease stage. CT scan was used to identify the growth and extent of tumor.  

Results: Majority cases were between the age group 41-50 years (40%). Epistaxis was the commonest clinical symptom in 72% cases followed by nasal obstruction (68%), oral related symptoms (56%), oedema in cheeks (44%) and auditory disturbances in 16% cases. The TNM Staging system showed that 76% cases had T3 lesions, 16% had T4 lesions and 8% had T2 lesions. Nasal symptoms are commonly associated with malignancies and were belongs to T3 stage and few under T4.

Conclusions: Maxillary si­nus malignancy is an aggressive tumor normally diagnosed at the advanced stage, with minimal prognosis and reduced survival rate. Surgery in combination with radiotherapy followed by chemotherapy remains the best treatment modality.

Author Biographies

C. P. Sudheer, Department of ENT, MNR Medical College and Hospital, Sangareddy, Telangana, India

Professor, Department of ENT, MNR Medical College and Hospital, Sangareddy, Telangana

T. Dinesh Singh, Department of ENT, Mallareddy institute of medical sciences, Suraram, Hyderabad, Telangana, India

Professor, Department of ENT, Mallareddy institute of medical sciences


Grant RN, Silverberg E. Cancer Statistics 1970. American Cancer Society, New York, 1970.

Kreppel M, Danscheid S, Scheer M, Lüers JC, Eich HT, Zöller JE, et al. Neoadjuvant chemoradiation in squamous cell carcinoma of the maxillary sinus: a 26-year experience. Chemother Res Pract. 2012.

Carrau RL, Myers EN, Johnson JT. Paranasal sinus carcinoma diagnosis, treatment, and prognosis. Oncology. 1992;6:43-50.

Vulpe H, Giuliani M, Goldstein D, Perez-Ordonez B, Dawson LA, Hope A. Long term control of a maxillary sinus mucoepidermoid carcinoma with low dose radiation therapy: a case report. Radiat Oncol. 2013;29:251.

Nishimura Y, Hattori M, Ohbu M, Kobayashi M, Konishi H, Miyazaki H, et al. Utility of intraoral washing cytology as a diagnostic technique in maxillary sinus carcinoma with oral invasion. Cytopathology. 2013;24:67-9.

Kuijpens JH, Louwman MW, Peters R, Janssens GO, Burdorf AL, Coebergh JW. Trends in sinonasal cancer in The Netherlands: more squamous cell cancer, less adenocarcinoma. A population-based study 1973–2009. Eur J Cancer. 2012;48:2369–74.

Youlden DR, Cramb SM, Peters S, Porceddu SV, Møller H, Fritschi L, et al. International comparisons of the incidence and mortality of sinonasal cancer. Cancer Epidemiol. 2013;37:770-9.

Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, et al. Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after super selective intra-arterial infusion of cisplatin with concurrent radiotherapy. Br J Oral Maxillofac Surg. 2014;52:323-8.

Bush SE, Bagshaw MA. Carcinoma of the paranasal sinuses. Cancer. 1982;50:154-8.

Gao N, Li Y, Li LJ, Wen YM. Clinical analysis of head and neck cancer cases in south-west China 1953 - 2002. J Int Med Res. 2009;37:189-97.

Chukuezi AB, Nwosu JN. Pattern of Nasal and Paranasal Sinus Tumours in Owerri, Nigeria. Research J Med Sci. 2010;4:11-4.

Tiwari R, Hardillo JA, Mehta D, Slotman B, Tobi H, Croonenburg E, et al. Squamous cell carcinoma of maxillary sinus. Head Neck. 2000;22:164-9.






Original Research Articles