Audiological assessment in organophosphorous poisoning
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20182400Keywords:
Organophosphate, Brainstem evoked response audiometryAbstract
Background: Organophosphate (OP) poisoning is a common cause of significant mortality and morbidity all over the world. In Asia, OP poisoning is the most common form of fatal self harm. Previous studies have suggested hearing loss due to OP poisoning. The aim of the study was to study audiological assessment in the patients with OP poisoning.
Methods: 26 patients (age <50 years) of OP poisoning over a period of one year were included in the study following ethical approval from Institute Ethics Committee. 25 healthy subjects served as control. Each subject was subjected to brainstem evoked response audiometry (BERA) examination.
Results: 50% patients with OP poisoning were aged between 20-29 years. Male outnumbered females in the patients (M:F- 17:9) as well as controls (M:F- 17:8). Only absolute wave-v latency (ms) was statistically significantly prolonged in cases when compared with controls in both right (0.035) as well as left ears (0.048). We found no statistical significant difference in interpeak wave I-III, III-V, I-V latency of both ears in cases when compared with controls. On second assessment in the patients, we observed a statistical significant decrease in absolute wave III and V latency, and interpeak I-III interval in right ear when compared with wave latency at first assessment. In left ear on second assessment, a significant decrease in absolute wave I, III, and V latency was observed in the patients.
Conclusions: OP compounds may affect entire neural auditory pathway. Further studies with a large sample size are required for the assessment.
References
Eddleston M, Gunnell D, Karunaratne A, de Silva D, Sheriff MHR, Buckley NA. Epidemiology of intentional self-poisoning in rural Sri Lanka. Br J Psychiatry. 2005;187(6):583-4.
WHO. Pesticides are a leading suicide method. World Heal Organ. 2010. Available at: http://www.who.int/mediacentre/news/notes/2006/np24/en/. Accessed on 15 January, 2017.
Bertolote JM, Fleischmann A, Eddleston M, Gunnell D. Deaths from pesticide poisoning: a global response. Br J Psychiatry. 2006;189(3):201-3.
National Health Services (NHS) Centre for Review and Dissemination, Deliberate Self-Harm. Eff Healthc Bull NHS Cent. 1998;4:1-12.
Phillips MR, Yang G, Zhang Y, Wang L, Ji H, Zhou M. Risk factors for suicide in China: a national case-control psychological autopsy study. Lancet. 2002;360(9347):1728-36.
Emerick GL, Peccinini RG, de Oliveira GH. Organophosphorus-induced delayed neuropathy: A simple and efficient therapeutic strategy. Toxicol Lett. 2010;192(2):238-44.
Perry MJ, May JJ. Noise and Chemical Induced Hearing Loss. J Agromedicine. 2005;10(2):49-55.
Teixeira CF, Giraldo Da Silva Augusto L, Morata TC. Occupational exposure to insecticides and their effects on the auditory system. Noise Health. 2002;4(14):31-9.
Beckett WS, Chamberlain D, Hallman E, May J, Hwang SA, Gomez M, et al. Hearing conservation for farmers: source apportionment of occupational and environmental factors contributing to hearing loss. J Occup Environ Med. 2000;42(8):806-13.
Harell M, Shea J, Emmett J. Bilateral sudden deafness following combined insecticide poisoning. Laryngoscope. 1978;88(8):1348-51.
Ashok Murthy V, Visweswara Reddy YJ. Audiological Assessment in Organophosphorus Compound Poisoning. Indian J Otolaryngol Head Neck Surg. 2014;66(1):22-5.
Banday TH, Tathineni B, Desai MS, Naik V. Predictors of Morbidity and Mortality in Organophosphorus Poisoning: A Case Study in Rural Hospital in Karnataka, India. N Am J Med Sci. 2015;7(6):259-65.
Jayasinghe SS, Pathirana KD, Buckley NA. Effects of acute organophosphorus poisoning on function of peripheral nerves: a cohort study. PLoS One. 2012;7(11):e49405.
Soni A, Kanaujia SK, Kaushik S. Brainstem Evoked Response Audiometry (BERA) in Neonates with Hyperbillirubinemia. Indian J Otolaryngol Head Neck Surg. 2016;68(3):334-8.
Gurkov R, Eshetu T, Barreto Miranda I, Berens-Riha N, Mamo Y, Girma T, et al. Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial. Malar J. 2008;7(1):179.
Weich TM, Tochetto TM, Seligman L. Brain stem evoked response audiometry of former drug users. Braz J Otorhinolaryngol. 2012;78(5):90-6.
Garg S, Sharma R, Mittal S, Thapar S. Alterations in brain-stem auditory evoked potentials among drug addicts. A cross-sectional study. Neurosci. (Riyadh). 2015;20(3):253-8.
