Audiological assessment in organophosphorous poisoning

Authors

  • Mahender Singh Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
  • R. S. Minhas Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
  • Prem Machhan Department of Medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
  • Ramesh Kumar Azad Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
  • Shobha Mohindroo Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20182400

Keywords:

Organophosphate, Brainstem evoked response audiometry

Abstract

Background: Organophosphate (OP) poisoning is a common cause of significant mortality and morbidity all over the world. In Asia, OP poisoning is the most common form of fatal self harm. Previous studies have suggested hearing loss due to OP poisoning. The aim of the study was to study audiological assessment in the patients with OP poisoning.

Methods: 26 patients (age <50 years) of OP poisoning over a period of one year were included in the study following ethical approval from Institute Ethics Committee. 25 healthy subjects served as control. Each subject was subjected to brainstem evoked response audiometry (BERA) examination.  

Results: 50% patients with OP poisoning were aged between 20-29 years. Male outnumbered females in the patients (M:F- 17:9) as well as controls (M:F- 17:8). Only absolute wave-v latency (ms) was statistically significantly prolonged in cases when compared with controls in both right (0.035) as well as left ears (0.048). We found no statistical significant difference in interpeak wave I-III, III-V, I-V latency of both ears in cases when compared with controls. On second assessment in the patients, we observed a statistical significant decrease in absolute wave III and V latency, and interpeak I-III interval in right ear when compared with wave latency at first assessment. In left ear on second assessment, a significant decrease in absolute wave I, III, and V latency was observed in the patients.

Conclusions: OP compounds may affect entire neural auditory pathway. Further studies with a large sample size are required for the assessment.

Author Biographies

Mahender Singh, Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Junior Resident, Department of Otolaryngology, IGMC Shimla

R. S. Minhas, Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Professor, Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, H.P

Prem Machhan, Department of Medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Associate Professor, Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, H.P.

Ramesh Kumar Azad, Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Professor, Department of Otorhinolaryngology, Indira Gandhi Medical College, Shimla, H.P

Shobha Mohindroo, Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Associate Professor, Department of Pathology, Indira Gandhi Medical College, Shimla, H.P

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Published

2018-06-23

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Original Research Articles