DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20181670

Efficacy of platelet rich fibrin in myringoplasty

Disha Sharma, Shobha Mohindroo, Ramesh K. Azad

Abstract


Background: Myringoplasty involves repair of tympanic membrane perforation with an autologous graft.The aim was to compare between myringoplasty with PRF and myringoplasty without fibrin.

Methods: This study was conducted from July 2016 to June 2017,100 patients were taken. In 50 patients platelet rich fibrin was placed over graft and external auditory canal during myringoplasty and 50 without PRF.  

Results: It was seen in the study that PRF improves overall success rate of myringoplasty study and there was significant improvement in ABG at 500 hz, 1000 hz, 2000 hz frequencies.

Conclusions: The higher success rate of myringoplasty with PRF was seen as compared to myringoplasty without fibrin. There were no noticeable side effects.


Keywords


Graft, Myringoplasty, PRF, 500 hz, 1000 hz, 2000 hz

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References


Kumar N, Chilke D, Puttewar MP. Clinical profile of tubotympanic CSOM and its management with special reference to site and size of tympanic membrane perforation, Eustachian tube function and three flap tympanoplasty. Indian J Otolaryngol Head Neck Surg. 2012;64(1):5-12.

Sankarnarayanan G, Prithviraj V, Kumar RV. A Study on efficacy of autologous platelet rich plasma in myringoplasty. Otolaryngology online Journal. 2013;3(3):2250-359.

Chauvin K, Bratton C, Parkins C. Healing large tympanic membrane perforations using hyaluronic acid, basic fibroblast growth factor, and epidermal growth factor. Otolaryngol Head Neck Surg 1999;121:43-7.

Habesoglu M, Oysu C, Yilmaz AS, Tosun A. Platelet rich fibrin for repair of tympanic membrane. J Craniofac Surg. 2014;25(6):2056-8.

Choukroun JI, Braccini F, Diss A, Giordano G, Doglioli P, Dohan DM. Influence of platelet rich fibrin (PRF) on proliferation of human preadipocytes and tympanic keratinocytes: A new opportunity in facial lipostructure (Coleman’s technique) and tympanoplasty. Rev Laryngol Otol Rhinol (Bord). 2007;128(1-2):27-32.

Garin P, Peerbaccus Y, Mardyla N, Mullier F, Gheldof D, Dogne JM, et al. Platelet-Rich Fibrin (PRF): an autologous packing material for middle ear microsurgery. B-ENT. 2014;10:27-34.

Vartiainen E, Kärjä J, Karjalainen S, Härmä R. Failures in myringoplasty. Arch Otorhinolaryngol. 1985;242(1):27-33.

Tang XBO, Dong PL, Wang J, Zhou HY, Zhang HX, Wang SZ. Effect of autologous platelet-rich plasma on the chondrogenic differentiation of rabbit adipose-derived stem cells in vitro. Exp Ther Med. 2015;10(2):477-83.

Sunitha RV, Naidu ME. Platelet rich fibrin- Evolution of a second generation platelet concentrate. Indian J Dent Res. 2008;19(1):42-6.

Alvaro MLN, Ortiz N, Rodriguez L, Boemeo R, Fuentes JF, Mateo A, et al. Research Article on pilot study on the efficiency of the biostimulation with autologous plasma rich in platelet growth factors in otorhinolaryngology: Otologic Surgery (Tympanoplasty Type 1). ISRN Surg. 2011;2011:451020.

Das A, Sen B, Ghosh D, Sengupta A. Myringoplasty: Impact of size and site of perforation on the success rate. Indian J Otolaryngol Head Neck Surg. 2015;67(2):185-9.