DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20160067

Fluticasone furoate verses fluticasone propionate: a comparative study by assessment of nasal mucociliary clearance time on patients with allergic rhinitis

Vimal Nambiar, Sheetal Rai, Gangadhar Somayaji K. S.

Abstract


Background: Allergic diseases in India have been on an uprising trend. 3.5% of the population in INDIA is suffering from Allergic Rhinitis. This study aims to compare the effectiveness of two commonly used intranasal steroids- Fluticasone Furoate (FF) and Fluticasone Propionate (FP) using the nasal mucociliary clearance time (NMCT).

Methods: We conducted a prospective study on 70 patients. 35 each on FF and FP. Pretreatment and Post treatment Nasal was assessed by Saccharin Test. Patients were then put on either FF or FP for a period of one month.  

Results: Average improvement of NMCT post treatment with steroids sprays is 2-3 minutes.(Average Pretreatment time is 17.92 and Average Post treatment time 15.55 minutes).

Conclusion: Both drugs are equally efficacious and well tolerated by the patients. Compliance of Fluticasone Furoate was better because of its once daily dosage. Disadvantages of FP are its twice daily dosage and after taste.

Keywords


Allergic rhinitis, Nasal mucociliary clearance time, Fluticasone furoate, Fluticasone propionate

Full Text:

PDF

References


Scadding G, Durham S. Allergic Rhinitis: Scott Browns Otolaryngology Head and Neck Surgery. London: Arnold H. 2008;2(7):1387.

Bousquet J, van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. Journal Of Allergy and Clinical Immunology. 2001;108:S147-334.

van Cauwenberge P, Bachert C, Passalacqa G. Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology. Allergy. 2000;55:116 -34.

Prasad R, Kumar R. Allergy situation in India: What is being done? Indian Journal of Chest Diseases and Allied Sciences. 2013;55:7-8.

Okubo K, Nakashima M, Miyake N. Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis: Allergy and Asthma Proceedings. 2009;30(1):84-94.

Yadav J, Verma A, Singh J. Study on Nasal Mucous Clearance in Patients of Perennial Allergic Rhinitis: Indian Journal of Allergy, Asthma and Immunology. 2003;17(2):89-91.

Okuda M. Grading the severity of allergic rhinitis for treatment strategy and drug study purposes. Current Allergy and Asthma Reports. 2001;1:235-41.

Okubo K, Nakashima M, Miyake N, Komatsubara M, Okuda M. Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis. Allergy and Asthma Proceedings. 2009;84(1):84-94.

Valotis A, Hogger P. Human receptor kinetics and lung tissue retention of the enhanced-affinity glucocorticoid fluticasone furoate. Respiratory Research. 2007;8:54.

Sorbera LA, Serradell N, Bolo SJ. Fluticasone furoate. Drugs of the Future. 2007;32:12-6.

Meltzer EO, Stahlman JE, Leflein J. Preferences of adult patients with allergic rhinitis for the sensory attributes of fluticasone furoate versus fluticasone propionate nasal sprays: A randomized, multicenter, double-blind, single-dose, crossover study. Clinical Therapeutics. 2009;30:271-79.