Economic aspect of tissue glue in thyroid surgeries

Harish M. O., Suresh Pillai


Background: Tissue glue or adhesives are the recent advances in closure of the skin wound. They have been used as an alternative to the sutures, staples and plasters. They have been found to be cosmetically better compared to other modes of wound closure. Whether the tissue glues are economically feasible for routine use has to be found out. The aims and objectives of this study is to find out the cost-effectiveness of tissue glue in comparison with traditional suture technique in thyroid surgeries.

Methods: This is a prospective study to find out the economic aspect of tissue glue in comparison with silk suture in fifty three patients who underwent thyroidectomy at Kasturba Medical College, Manipal.  

Results: The overall cost for tissue glue procedure was significantly less when compared to silk suture technique.

Conclusions: Iso amyl-2-cyanoacrylate is excellent tissue glue. Though the initial cost of tissue glue is higher compared to silk sutures, the overall cost including the anaesthetic cost, hospital stay and reviews is considerably less. Thus we conclude that the tissue glue is economically cheaper compared to suture methods.


Tissue glue, Wound healing, Silk sutures, Iso amyl-2-cyanoacrylate

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Snyder CC. On the history of suture. Bull Hist Dent. 1977;25:79–84.

Molan PC. The antibacterial activity of honey. The nature of the antibacterial activity. Bee World. 1992;73(1):5-28.

Scott M. 32,000 years of suture. NATNews. 1983;20:15–7.

Steichen FNM, Ravitch. Mechanical sutures in surgery. Br J Surg. 1973;60:191-7.

Johnson A, Rodeheaver GT, Durand LS, Edgerton MT, Eldich RF. Automatic disposable stapling devices for wound closure. Annals Emerg Med. 1981;12:631-5.

Mobley SR, Hilinski J, Toriumi DM. Facial Plast Surg Clin N Am. 2002;10:147–54.

Coover HW, Joyner FB. Chemistry and performance of cyanoacrylate adhesives. J Soc Plast Eng. 1959;15:413-7.

Mizrahi S, Bickel A, Ben-Layish E. Use of tissue adhesives in the repair of lacerations in children. J Pediatr Surg. 1988;23(4):312–3.

Kamer FM, Joseph JH. Histoacryl- Its use in aesthetic facial plastic surgery. Arch Otolaryngol Head Neck Surg. 1989;115(2):193–7.

Quinn J, Maw J, Ramotar K, Wenckebach G, Wells G. Octylcyanoacrylate tissue adhesive versus suture wound repair in a contaminated wound model. Surgery. 1997;122(1):69–72.

Bruns TB, Robinson BS, Smith RJ, Kile DL, Davis TP, Sullivan KM, et al. A new tissue adhesive for laceration repair in children. J Pediatr. 1998;132(6):1067–70.

Quinn J, Wells G, Sutcliffe T, Jarmuske M, Maw J, Stiell I, et al. A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. JAMA. 1997;277:1527.

Singer AJ, Hollander JE, Valentine SM, Turque TW, McCuskey CF, Quinn JV. Prospective, randomized, controlled trial of tissue adhesive (2-octylcyanoacrylate) vs standard wound closure techniques for laceration repair. Stony Brook Octylcyanoacrylate Study Group. Acad Emerg Med. 1998;5(2):94–9.

Toriumi DM, Raslan WF, Friedman M, Tardy ME Jr. Histotoxicity of tissue adhesives. Arch Otolaryngol Head Neck Surg. 1990;116:546-50.

Toriumi DM, Raslan WF, Friedman M, Tardy ME Jr. Variable histotoxicity of histoacryl when used in a subcutaneous site: an experimental study. Laryngoscope. 1991;101:339-43.

Matthews TW, Briant TD. The use of fibrin tissue glue in thyroid surgery: resource utilization implications. J Otolaryngol. 1991;20:276–8.

Jennifer L, James Quinn. A prospective comparison of octylcyanoacrylate tissue adhesive and suture for closure of head and neck incisions. J Otolaryngol. 1997;26(1):26-30.

DM Ridgway, F Mahmood. A Blinded, Randomised, Controlled Trial of Stapled Versus Tissue Glue Closure of Neck Surgery Incisions. Ann R Coll Surg Engl. 2007;89(3):242–6.

Amin M, Glynn F, Timon C. Randomized trial of tissue adhesive vs staples in thyroidectomy integrating patient satisfaction and Manchester score. Otolaryngol Head Neck Surg. 2009;140:703-8.