Clinical findings and risk factors associated with oral cancer: a prospective study


  • Yashna Gupta Department of Radiation Oncology, Delhi State Cancer Institute, New Delhi, India
  • Parvinder Singh Department of ENT, PCMS, Civil Hospital, Samana, Punjab, India
  • Neeru Bedi Department of Radiation Oncology, GMC Patiala, Punjab, India
  • Pardeep Garg Department of Radiotherapy, GGSMCH, Faridkot, Punjab, India
  • Raja Paramjit Singh Banipal Department of Radiotherapy, GGSMCH, Faridkot, Punjab, India



Buccal mucosa, Cancer, Risk factors, Tongue


Background: Oral cancer is associated with high morbidity and mortality and therefore it represents a grave health problem worldwide. However there is scarcity of the studies in the literature regarding the prognostic factors amongst the subjects. The aim of the present study is to determine the various risk factors and the most commonly affected sites by the oral squamous cell carcinoma amongst subjects of different age groups.

Methods: The present prospective comparative study was conducted at the Department of Radiotherapy at Guru Gobind Singh Medical College and Hospital during a period of three months i.e. from April 2016 to June 2016. Patients were evaluated every week for a period of approximately 2 weeks. Examination of the oral cavity was done using probe and mouth mirror by trained personnel. TNM classification was used to classify tumour. Patient’s habits like alcohol and tobacco intake were also recorded. Complete demographic information was obtained from all the patients. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software.  

Results: The study included a total of 60 subjects. There were 11 females in the study and 49 males in the study. There were 18.3% (n=11) subjects having cancer of tongue. There were 23.3% (n=14) subjects having cancer of buccal mucosa. Alveolar ridge carcinoma was seen in 8.3% (n=5) subjects. There were 22 patients (30%) having stage III carcinoma. Majority of the subjects i.e. 70% (n= 38) were at stage IV A according to TNM classification.

Conclusions: From the above study we can conclude that there is lack of awareness amongst the people about oral cancer. They mostly present during advanced stage of the disease. Most of the subjects are males, showing there predisposition towards harmful habits.


Lambert R, Sauvaget C, de Camargo M, Sankaranarayanan R. Epidemiology of cancer from the oral cavity and oropharynx. Eur J Gastroenterol Hepatol. 2011;23(8):633-41.

Zini A, Czerninski R, Sgan-Cohen HD. Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites. J Oral Pathol Med. 2010;39(4):299-305.

Seoane-Romero JM, Vázquez-Mahía I, Seoane J, Varela-Centelles P, Tomás I, López-Cedrún JL. Factors related to late stage diagnosis of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2012;17(1):35-40.

Johnson NW, Jayasekara P, Amarasinghe AA. Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology. Periodontol 2000. 2011;57:19-37.

Albuquerque R, Lopez-Lopez J, Mari-Roig A, Jane-Salas E, Rosello- Llabres X, Santos JR. Oral tongue squamous cell carcinoma (OTSCC): alcohol and tobacco consumption versus non-consumption. A study in a Portuguese population. Braz Dent J. 2011;22:517-21.

Moyses RA, López RV, Cury PM, Siqueira SA, Curioni OA, Gois Filho JF, et al. Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients. Clinics (Sao Paulo). 2013;68:738-44.

Ribeiro AC, Silva AR, Simonato LE, Salzedas LM, Sundefeld ML, Soubhia AM. Clinical and histopathological analysis of oral squamous cell carcinoma in young people: a descriptive study in Brazilians. Br J Oral Maxillofac Surg. 2009;47:95-8.

Soudry E, Preis M, Hod R, Hamzany Y, Hadar T, Bahar G, et al. Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome. Clin Otolaryngol. 2010;35:307-12.

Udeabor SE, Rana M, Wegener G, Gellrich NC, Eckardt AM. Squamous cell carcinoma of the oral cavity and the oropharynx in patients less than 40 years of age: a 20-year analysis. Head Neck Oncol. 2012;4:28.

Majchrzak E, Szybiak B, Wegner A, Pienkowski P, Pazdrowski J, Luczewski L, et al. Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol Oncol. 2014;48:1-10.

Monteiro LS, Amaral JB, Vizcaíno JR, Lopes CA, Torres FO. A clinical-pathological and survival study of oral squamous cell carcinomas from a population of the North of Portugal. Med Oral Patol Oral Cir Bucal. 2014;19:120-6.

Toner M, O’Regan EM. Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1. Head Neck Pathol. 2009;3:246-8.

Falaki F, Dalirsani Z, Pakfetrat A, Falaki A, Saghravanian N, Nosratzehi T, et al. Clinical and histopathological analysis of oral squamous cell carcinoma of young patients in Mashhad, Iran: a retrospective study and review of literature. Med Oral Patol Oral Cir Bucal. 2011;16:473-7.

Troeltzch M, Knösel T, Eichinger C, Probst F, Troeltzsch M, Woodlock T, et al. Clinicopathologic features of oral squamous cell carcinoma: do they vary in different age groups? J Oral Maxillofac Surg. 2014;72:1291-300.

Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T, et al. Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol. 2011;29:1488-94.

Mesquita JA, Queiroz LM, Silveira ÉJ, Gordon-Nunez MA, Godoy GP, Nonaka CF, et al. Association of immunoexpression of the galectins-3 and -7 with histopathological and clinical parameters in oral squamous cell carcinoma in young patients. Eur Arch Otorhinolaryngol. 2016;273:237-43.

Fonseca FP, Coletta RD, Azevedo MB, Prado Ribeiro AC, Pires Soubhia AM, Miyahara GI, et al. Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients - a multicenter collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:483-9.

Alves PM, Godoy GP, Gomes DQ, Medeiros AM, de Souza LB, da Silveira EJ, et al. Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue. Pathol Res Pract. 2011;207:236-40.

Ganly I, Patel S, Shah J. Early stage squamous cell cancer of the oral tongue--clinicopathologic features affecting outcome. Cancer. 2012;118(1):101-11.

Kreppel M, Drebber U, Rothamel D, Eich HT, Kübler A, Scheer M, et al. Prognostic impact of different TNM-based stage groupings for oral squamous cell carcinoma. Head Neck. 2011;33(10):1467-75.

Hellen-Bandeira-de-Pontes Santos T, dos Santos KG, Paz AR, Cavalcanti YW, Cassiano-Francisco-Weege Nonaka GP, Godoy PM. Clinical findings and risk factors to oral squamous cell carcinoma in young patients: A 12-year retrospective analysis. Medicina oral, patologia oral y cirugia bucal. 2016;21(2):151.

Oliveira ML, Wagner VP, Sant'ana Filho M, Carrard VC, Hugo FN, Martins MD. A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay. Brazilian oral research. 2015;29(1):1-8.






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