Epitheloid hemangio-endothelioma of right aryepiglottic fold: a rare case report with review of literature

Alpesh D. Fefar, Paresh J. Khavdu, Mukesh N. Dodia, Sejal N. Mistry, Manish R. Mehta


Epitheloid hemangio-endothelioma is a very rare tumour of intermittent malignancy of vascular origin, having a tendency to recur with rare incidence of metastasis. The tumour is intermediate between haemangioma and angiosarcoma, mainly affecting liver, lung as well as bones, skin, penis, ovary, scalp, or any part of the body. Internet search was made with the key words epitheloid hemangio-endothelioma and epitheloid hemangio-endothelioma of Larynx, since now only single case has been reported from larynx involving subglottis. Hence we report this rare entity with involvement of the larynx (Sub site: Rt. Aryepiglottic fold) describing clinical and histopathological characteristic. This is perhaps the first case of epitheloid hemangio-endothelioma involving aryepiglottic fold.


Epitheloid hemangio-endothelioma, Aryepiglottic fold, Larynx

Full Text:



Pinto José Antonio, Fernandes Lis Tozatti, El Ibrahim Roberto. Epithelioid hemangioendothelioma of larynx. Revista Brasileira de Cirurgia da Cabeça e Pescoço. 1993;17(3):179-82.

Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for carcinoma. Cancer. 1982;50:970-81.

Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer FW. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol. 1984;15:839-52.

Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 1999;85:562-82.

Dial DH, Liebow AA, Gmelich JT, Friedman PJ, Miyai K, Myer W, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT): an analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer. 1983;51:452-64.

Elias KR, Ryan CK. Epithelioid hemangio-endothelioma and the elusive vacuole. Liver Transpl. 2003;9:310-2.

Fryer JA, Biggs MT, Katz IA, Brazier DH, Shakespeare TP. Intracranial epithelioid hemangioendothelioma arising at site of previously atypical meningioma. Pathology. 1998;30:95-9.

Hamlat A, Casallo-Quilliano C, Saikali S, Lesimple T, Brassier G. Epithelioid hemangiendothelioma of the infundibular-hypothalamic region: case report and literature review. J Neurooncol. 2004;67:361-6.

Chow L, Chow W, Fong DT. Epithelioid hemangioendothelioma of the brain. Am J Surg Pathol. 1992;16:619-25.

Lee JC, Lee BJ, Wang SG, Kim HW. Epithelioid haemangioendothelioma in the parapharyngeal space. J Laryngol Otol. 2006;120:505-7.

Safirstein J, Aksenov S, Smith F. Cardiac epithelioid hemangioendothelioma with 8-year follow-up. Cardiovasc Pathol. 2007;16:183-6.

Kleer CG, Unni KK, Mcleod RA. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol. 1996;20:1301-11.

Quante M, Patel NK, Hill S, Merchant W, Courtauld E, Newman P, et al. Epithelioid hemangioendothelioma presenting in the skin: a clinicopathologic study of eight cases. Am J Dermatopathol. 1998 Dec;20(6):541-6.

Weiss SW, Goldblum J, Enzinger FM. Liver and lung lesions. In: Weiss SW, Goldblum J, Enzinger FM, eds. Enzinger and Weiss’ Soft Tissue Tumors. 4th ed. Philadelphia, PA: Mosby; 2001:891-914.