T1 and T2 glottic squamous cell carcinoma: endoscopic laser surgery versus radiotherapy experience in a cancer center in Mexico

Kuauhyama Luna-Ortiz; Veronica Villavicencio-Valencia; Zelik Luna-Peteuil; Dorian Y. García-Ortega; Saul Favila-Lira; Diana Villavicencio-Valencia; Philippe Pasche

doi:10.18203/issn.2454-5929.ijohns20262372

Authors

Kuauhyama Luna-Ortiz Department of Head and Neck Surgery Instituto Nacional de Cancerología https://orcid.org/0000-0002-1862-4036
Veronica Villavicencio-Valencia Department of Head and Neck Surgery Instituto Nacional de Cancerología https://orcid.org/0000-0002-7025-1484
Zelik Luna-Peteuil Universitatea de Medicinâ și Farmacie Grigore T. Popa Iași https://orcid.org/0000-0003-1720-0423
Dorian Y. García-Ortega Department of Surgical Oncology Instituto Nacional de Cancerología https://orcid.org/0000-0002-1302-2896
Saul Favila-Lira National Autonomous University of Mexico https://orcid.org/0009-0007-0643-3754
Diana Villavicencio-Valencia Department of Head and Neck Surgery Instituto Nacional de Cancerología https://orcid.org/0009-0004-5125-1843
Philippe Pasche ORL and Cervocofacial surgery, Hirslanden Clinic, Lausanne https://orcid.org/0000-0002-8160-7589

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20262372

Keywords:

Early laryngeal cancer, Endoscopic, Laser, Microlaryngoscopy, Organ preservation, Recurrence, Radiotherapy, Survival, Surgery, Transoral approach

Abstract

Background: Radiotherapy and endoscopic laser surgery (ELS) has been considered the primary treatment for laryngeal cancer. This study aims to compare ESL and radiotherapy in terms of organ preservation, disease-free survival, overall survival and cancer-specific survival.

Methods: A retrospective study using database of T1-T2 glottic cancer treated with radiotherapy and ELS. Disease-free survival, overall survival and cancer specific survival (CSS) for both groups according to Kaplan-Meier.

Results: 108 patients received radiotherapy and 98 patients underwent ELS were analyzed. Organ preservation rate was higher in the ELS group (88.8% vs 84.3%) p=NS. The percentage of patients alive without disease was higher in the ELS group (85.7% vs 58.3%) (p< 0.00). The five-year general OS rates were 93% and 91% in the ELS and radiotherapy group, respectively; while the ten-year OS rates were 93% and 63%, respectively. The five-year and ten-year OS rates for T1 and T2 (p=NS). Five-year CSS in the ELS and radiotherapy group was, respectively, 86% and 85%, whereas ten-year CSS was 83% and 50%, respectively (p=NS). A sub analysis of recurrent cases was performed for both groups. Organ preservation was achieved in 71.1% of cases in the ELS group compared with 58% in the radiotherapy group (p=0.23).

Conclusions: T1 tumors should be exclusively treated with ELS or open surgery, diagnosis and treatment can be combined in a single surgical procedure. Before administering radiotherapy, a diagnosis is needed. T2 tumors should be properly selected for their management and many approaches are available. Organ preservation is similar for both groups.

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