Radiological, cytological and histopathological correlation in patients undergoing thyroid surgery at a tertiary care hospital in western Gujarat: a cross-sectional study

Authors

  • Rashmi Sorathiya Department of Otorhinolaryngology, Gujarat, Adani Institute of Medical Sciences, Bhuj, Gujarat, India
  • Sharvil Nimavat Department of Otorhinolaryngology, Gujarat, Adani Institute of Medical Sciences, Bhuj, Gujarat, India
  • Narendra Hirani Department of Otorhinolaryngology, Gujarat, Adani Institute of Medical Sciences, Bhuj, Gujarat, India
  • Ajeet Kumar Khilnani Department of Otorhinolaryngology, Gujarat, Adani Institute of Medical Sciences, Bhuj, Gujarat, India
  • Ayush Tank Department of Otorhinolaryngology, Gujarat, Adani Institute of Medical Sciences, Bhuj, Gujarat, India
  • Mansi Patel Department of Otorhinolaryngology, Gujarat, Adani Institute of Medical Sciences, Bhuj, Gujarat, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20250115

Keywords:

Bethesda, Cytology, Histopathology, TIRADS, Ultrasonography

Abstract

Introduction: Thyroid gland is affected by various pathologies ranging from diffuse enlargement (goiter) to nodular lesions, thyroiditis, and malignancies. Fine needle aspiration cytology (FNAC) is a simple & most cost-effective method to diagnose neck mass located superficially. Ultrasonography (USG) is the initial imaging modality in the evaluation of the neck swellings. The objective of the study being to correlate cytology, radiology and histopathology of patients undergoing thyroid surgery in our tertiary care center.

Methods: All patients who were operated for thyroid gland surgery at our tertiary care hospital of western Gujarat at Ear, Nose, and Throat Department between October 2022 to March 2024 were analysed using statistical software. This study included 54 patients.

Results: Out of the fifty-four (54) individuals who showed signs of thyroid enlargement, forty-five (45) were women and 9 were men. The average age of the participants in this research was 43.25±15.50 years. In our research, 79.67% of patients were classified as benign, 12.96% as malignant, and 7.4% were considered suspicious for malignancy. Only 10% were moderately suspicious of cancer (category IV). No patient was identified as highly suspicious of cancer (category V). FNAC specificity for benign was 95.24% and for malignant 93.02%. For TIRADS specificity was 93.33% for benign and 95.45% malignant.

Conclusions: Most of the times it is easy to diagnose a thyroid swelling by clinical, radiological, cytological and histo-pathological examinations. Our study analyses FNAC with Bethesda, USG with TIRADS as a most important aspect for early diagnosis carcinoma of thyroid.

Metrics

Metrics Loading ...

References

Prabha V, Bhuvaneswari MG. A study of histopathological spectrum of thyroid lesions: an observational study. Int J Sci Stud. 2019;7(1):1-4.

Kopperundevi V. Histopathological review of thyroid swellings a retrospective study. Int J Med Health Res. 2016;2(5):10-3.

Ramteke DJ, Mulay PS. Cyto-histopathological correlation of thyroid lesions. Int J Res Med Sci. 2017;5:1425-9. DOI: https://doi.org/10.18203/2320-6012.ijrms20171239

Haugen BR, Alexander EK, Bible KC. American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):12–6. DOI: https://doi.org/10.1089/thy.2015.0020

Mendes GF, Garcia MR, Falsarella PM, Rahal A, Cavalcante Junior FA, Nery DR, Garcia RG. Fine needle aspiration biopsy of thyroid nodule smaller than 1.0 cm: accuracy of TIRADS classification system in more than 1000 nodules. Br J Radiol. 2018;91(1083):20170642. DOI: https://doi.org/10.1259/bjr.20170642

Santosh UP, Kumar SKB, Trupthi MC, Bobobalan S. A comprehensive approach to thyroid swellings: clinical, cytological, sonological and histopathological correlation. Otolaryngol Clin Int J. 2014;6(1):5-8. DOI: https://doi.org/10.5005/jp-journals-10003-1143

Kumari K, Mrudula R. Solitary thyroid nodule: cytopathology and histopathology. Eur J Biomed Pharmaceut Sci. 2014;1(2):482-90.

Wani KA, Mustafa GH, Wani RA, Hussain Z, Arif SH, Malik AA, et al. Clinical study of neoplastic thyroid swellings with reference to surgical management. JK Pract. 2007;14(1):19-21.

Rout K, Ray CS, Behera SK, Biswal R. A comparative study of FNAC and histopathology of thyroid swellings. Indian J Otolaryngol Head Neck Surg. 2011;63(4):370-2. DOI: https://doi.org/10.1007/s12070-011-0280-0

Amjad KM, Abdul M, Moosabba MS, Manjula S, Pushpalatha P. A clinicopathological study and management of thyroid swelling. J Adv Res Biol Sci. 2011;3(1):1-5.

Gupta M, Gupta S, Gupta V. Correlation of fine needle aspiration cytology with histopathology in the diagnosis of solitary thyroid nodules. J Thyroid Res. 2010;1:37905. DOI: https://doi.org/10.4061/2010/379051

Padmawar MR, Kher K, Kakade A. Clinicopathological study of multinodular goiter at AVBRH. Int J Biomed Adv Res. 2014;5(1):10-3. DOI: https://doi.org/10.7439/ijbar.v5i1.557

Kaur K, Sonkhya N, Bapna A, Mital P. A comparative study of fine needle aspiration cytology, ultrasonography and radionuclide scan in the management of solitary thyroid nodule: a prospective analysis of 50 cases. Indian J Otolaryngol Head Neck Surg. 2002;54(2):96-101. DOI: https://doi.org/10.1007/BF02968725

Dorairajan N, Jayashree N. Solitary thyroid nodules and role of fine needle aspiration cytology in diagnosis. J Indian Med Assoc. 1996;94(2):50-2.

Gharib H, Goellner JR. Fine needle aspiration biopsy of thyroid: an appraisal. Ann Intern Med. 1993;119:282-9. DOI: https://doi.org/10.7326/0003-4819-118-4-199302150-00007

Looty H. Practice, efficacy, cost of thyroid nodule evaluation, a retrospective study in a Dutch University Hospital. Thyroid. 2004;14(4):287-93. DOI: https://doi.org/10.1089/105072504323030942

Kwak JY, Han KH, Yoon JH, Moon HJ, Son EJ, Park SH, et al. Thyroid imaging reporting and data system for ultrasound features of nodules: a step in establishing better stratification of cancer risk. Radiol. 2011;260:892-9. DOI: https://doi.org/10.1148/radiol.11110206

Moifo B, Takoeta EO, Tambe J, Blanc F, Fotsin JG. Reliability of thyroid imaging reporting and data system (TIRADS) classification in differentiating benign from malignant thyroid nodules. Open J Radiol. 2013;3:103. DOI: https://doi.org/10.4236/ojrad.2013.33016

Srinivas MN, Amogh VN, Gautam MS, Prathyusha IS, Vikram NR, Retnam MK, et al. A prospective study to evaluate the reliability of thyroid imaging reporting and data system in differentiation between benign and malignant thyroid lesions. J Clin Imaging Sci. 2016;6:5. DOI: https://doi.org/10.4103/2156-7514.177551

Horvath E, Majlis S, Rossi R, Franco C, Niedmann JP, Castro A, et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab. 2009;94(5):1748-51. DOI: https://doi.org/10.1210/jc.2008-1724

Fenn AS. Solitary nodule of thyroid gland. Indian J Surg. 1980;42:175-7.

Basharat R, Bukhari MH, Saeed S, Hamid T. Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule. Patholog Res Int. 2011;2:7540-1. DOI: https://doi.org/10.4061/2011/754041

Jena A, Patnayak R, Prakash J, Sachan A, SureshV LA. Malignancy in solitary thyroid nodule: a clinicoradiopathological evaluation. Indian J Endocr Metab. 2015;19(4):498-503. DOI: https://doi.org/10.4103/2230-8210.159056

Borgohain R, Lal RK, Chatterjee P, Brahma N, Khanna S. A study of cytohistological correlation in the diagnosis of thyroid swelling. IOSR J Dent Med Sci. 2014;13:46-9. DOI: https://doi.org/10.9790/0853-131144649

Yeung MJ, Serpell JW. Management of the solitary thyroid nodule. Oncologist. 2008;13(2):105-12. DOI: https://doi.org/10.1634/theoncologist.2007-0212

Kim YA, Park YJ. Prevalence and risk factors of subclinical thyroid disease. Endocrinol Metab (Seoul). 2014;29(1):20-9. DOI: https://doi.org/10.3803/EnM.2014.29.1.20

Patel KN, Yip L, Lubitz CC, Grubbs EG, Miller BS, Shen W, et al. The American association of endocrine surgeon’s guidelines for the definitive surgical management of thyroid disease in adults. Ann Surg. 2020;271(3):21-93. DOI: https://doi.org/10.1097/SLA.0000000000003580

Downloads

Published

2025-01-27

How to Cite

Sorathiya, R., Nimavat, S., Hirani, N., Khilnani, A. K., Tank, A., & Patel, M. (2025). Radiological, cytological and histopathological correlation in patients undergoing thyroid surgery at a tertiary care hospital in western Gujarat: a cross-sectional study. International Journal of Otorhinolaryngology and Head and Neck Surgery, 11(1), 28–33. https://doi.org/10.18203/issn.2454-5929.ijohns20250115

Issue

Section

Original Research Articles