A demographic study of clinically diagnosed patients of oral submucous fibrosis visiting ENT outpatient department of a tertiary care hospital in Muzaffarnagar district, Uttar Pradesh, India

Authors

  • Ramanuj Bhardwaj Department of ENT and HNS, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh, India
  • Aamir Hafiz Department of ENT and HNS, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh, India
  • Seerat Bashir Department of ENT and HNS, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20251499

Keywords:

OSF, OSMF, Oral lesions, Oral disease, Fibrosis, Betel nut, Areca nut, Tobacco, Mouth opening, Burning sensation

Abstract

Background: Oral submucous fibrosis is a premalignant condition affecting the oral cavity. It is characterized by fibrosis of the submucosal tissues, leading to restricted mouth opening, dryness, burning sensation etc. It causes significant mortality after its transformation into squamous cell carcinoma (SCC). It has now become a global health concern.

Methods: The study was conducted amongst the patients aged 18-65 years who visited the ENT OPD of Muzaffarnagar Medical College with oral lesions from 01 January 2024 to 30 June 2024 (6 months). Of these patients that were clinically diagnosed with oral submucous fibrosis (OSMF), were given a detailed questionnaire and further studied. It was a hospital based cross sectional study conducted by Department of ENT and HNS, Muzaffarnagar Medical College and Hospital.  

Results: Of the 120 cases clinically diagnosed cases of OSMF. Mean age was 42.7 years. Most patients were in 4th and 5th decade of life and specifically in 31-40-years age range. Male to female ratio was 3.61: 1. Most patients came from rural areas. Gutkha was the most commonly used habit in these patients. M2 was the most common stage at which the patients visited the hospital. Muslims were predominant in the study population.

Conclusions: OSMF is an irreversible process, it has been linked to habitual consumption of betel nut, due to its high prevalence, special emphasis should be given towards its prevention and awareness. Also, due to its increased risk of malignant transformation, prompt cessation of the particular etiological agent and early management of the disease is required. Primary healthcare professionals and dentists should be familiar with its clinical presentation, diagnosis and management.

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References

Haider SM, Merchant AT, Fikree FF, Rahbar MH. Clinical and functional staging of oral submucous fibrosis. Br J Oral Maxillofac Surg. 2000;38(1):12-5. DOI: https://doi.org/10.1054/bjom.1999.0062

Dionne KR, Warnakulasuriya S, Zain RB, Cheong SC. Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory. Int J Cancer. 2015;136:503-15. DOI: https://doi.org/10.1002/ijc.28754

Chole RH, Gondivkar SM, Gadbail AR, Balsaraf S, Chaudhary S, Dhore SV, et al. Review of drug treatment of oral submucous fibrosis. Oral Oncol. 2012;48(5):393-8. DOI: https://doi.org/10.1016/j.oraloncology.2011.11.021

Shih YH, Wang TH, Shieh TM, Tseng YH. Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy. Int J Mol Sci. 2019;20(12):2940. DOI: https://doi.org/10.3390/ijms20122940

Zhang X, Reichart PA. A review of betel quid chewing, oral cancer and precancer in Mainland China. Oral Oncol. 2007;43:424-30. DOI: https://doi.org/10.1016/j.oraloncology.2006.08.010

Tilakaratne WM, Ekanayaka RP, Warnakulasuriya S. Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(2):178-91. DOI: https://doi.org/10.1016/j.oooo.2016.04.003

Chattopadhyay A, Ray JG. Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis. J Environ Pathol Toxicol Oncol. 2016;35(3):193-205. DOI: https://doi.org/10.1615/JEnvironPatholToxicolOncol.2016014024

Chang MC, Chiang CP, Lin CL, Lee JJ, Hahn LJ, Jeng JH. Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol. 2005;41(8):757-75. DOI: https://doi.org/10.1016/j.oraloncology.2005.01.007

Cox SC, Walker DM. Oral submucous fibrosis. A review. Aust Dent J. 1996;41:294-9. DOI: https://doi.org/10.1111/j.1834-7819.1996.tb03136.x

Nigam NK, Aravinda K, Dhillon M, Gupta S, Reddy S, Srinivas Raju M. Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district. J Oral Biol Craniofac Res. 2014;4(1):8-13.

Gottipamula S, Sundarrajan S, Moorthy A, Padmanabhan S, N Sridhar K. Buccal Mucosal Epithelial Cells Downregulate CTGF Expression in Buccal Submucosal Fibrosis Fibroblasts. J Maxillofac Oral Surg. 2018;17(2):254-9. DOI: https://doi.org/10.1007/s12663-017-1056-1

Balakrishnan C, Aswath N. Estimation of serum, salivary immunoglobulin G, immunoglobulin A levels and total protein, hemoglobin in smokeless tobacco chewers and oral submucous fibrosis patients. Contemp Clin Dent. 2015;6:S157-62. DOI: https://doi.org/10.4103/0976-237X.166820

Arakeri G, Rai KK, Hunasgi S, Merkx MAW, Gao S, Brennan PA. Oral submucous fibrosis: An update on current theories of pathogenesis. J Oral Pathol Med. 2017;46(6):406-12. DOI: https://doi.org/10.1111/jop.12581

Guruprasad R, Nair PP, Singh M, Singh M, Singh M, Jain A. Serum vitamin c and iron levels in oral submucous fibrosis. Indian J Dent. 2014;5(2):81-5. DOI: https://doi.org/10.4103/0975-962X.135266

Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A, Chang JY. High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. J Formos Med Assoc. 2015;114(9):813-9. DOI: https://doi.org/10.1016/j.jfma.2015.05.011

Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol. 2006;42(6):561-8. DOI: https://doi.org/10.1016/j.oraloncology.2005.08.005

More C, Gupta S, Joshi J, Verma S. Classification System for Oral Submucous Fibrosis. J Indian Acad Oral Med Radiol. 2012;24:24-9. DOI: https://doi.org/10.5005/jp-journals-10011-1254

Cai X, Yao Z, Liu G, Cui L, Li H, Huang J. Oral submucous fibrosis: A clinicopathological study of 674 cases in China. J Oral Pathol Med. 2019;48:321-5. DOI: https://doi.org/10.1111/jop.12836

Ariyawardana A, Nawagamuwa T, Ranasinghe AW, Sitheeque M, Vithanaarachchi N. Conservative Management of Oral Submucous Fibrosis. Asian J Oral Maxillofac Surg. 2005;17(1):26-30. DOI: https://doi.org/10.1016/S0915-6992(05)80005-6

Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral submucous fibrosis: study of 1000 cases from central India. J Oral Pathol Med. 2007;36(1):12-7. DOI: https://doi.org/10.1111/j.1600-0714.2006.00485.x

Rai S, Rattan V, Gupta A, Kumar P. Conservative management of Oral Submucous Fibrosis in early and intermediate stage. J Oral Biol Craniofac Res. 2018;8(2):86-8.

Rela R, Dongarwar GR. Oral submucous fibrosis: Clinical study. Int J Appl Dent Sci. 2018;4(4):302-4.

Nigam NK, Aravinda K, Dhillon M, Gupta S, Reddy S, Srinivas Raju M. Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district. J Oral Biol Craniofac Res. 2014;4(1):8-13. DOI: https://doi.org/10.1016/j.jobcr.2013.10.005

Rai S, Rattan V, Gupta A, Kumar P. Conservative management of Oral Submucous Fibrosis in early and intermediate stage. J Oral Biol Craniofac Res. 2018;8(2):86-8. DOI: https://doi.org/10.1016/j.jobcr.2017.06.002

Kumar S. Oral submucous fibrosis: A demographic study. J Indian Acad Oral Med Radiol. 2016;28:124‐8. DOI: https://doi.org/10.4103/0972-1363.195085

Raina C, Raizada RM, Chaturvedi VN, Harinath BC, Puttewar MP, Kennedy AK. Clinical profile and serum beta-carotene levels in oral submucous fibrosis. Indian J Otolaryngol Head Neck Surg. 2005;57(3):191-5. DOI: https://doi.org/10.1007/BF03008011

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Published

2025-05-27

How to Cite

Bhardwaj, R., Hafiz, A., & Bashir, S. (2025). A demographic study of clinically diagnosed patients of oral submucous fibrosis visiting ENT outpatient department of a tertiary care hospital in Muzaffarnagar district, Uttar Pradesh, India . International Journal of Otorhinolaryngology and Head and Neck Surgery, 11(3), 215–220. https://doi.org/10.18203/issn.2454-5929.ijohns20251499

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Original Research Articles