Xanthoma of the larynx: a rare mucosal presentation
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20251508Keywords:
Xanthoma, Larynx, HistopathologyAbstract
Xanthoma is a reactive condition of localized collection of lipid laden histiocytes with common presentation in skin, subcutis or tendon. Musoca associated xanthomatous lesions are rare presentation. These lesions may be asymptomatic or have symptoms like throat discomfort, hoarseness. These lesions are mostly associated with dyslipidemia. Due to rarity of its presentation it can be endoscopically mistaken for polyp or malignancy. Hereby, we report a case of 42-year-old male with new onset diabetes type II. He presented to ENT OPD with change in voice for few months. He underwent nasopharyngolarngoscopy and was clinically diagnosed as vocal cord polyp. Microlaryngeal excision was done and sent for histopathology. Histopathology revealed polypoid squamous epithelium covered lesion with sheets of foamy macrophages in the stroma thus confirmed the diagnosis of xanthoma, larynx. Mucosa associated xanthoma are rare presentations and may indicate a possibility of underlying metabolic disease.
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Weis SW, Goldblum JR. Enzinger and Weiss Soft Tissue Tumors. 7th edition. St. Louis, Mo, USA: Mosby. 2020.
Matsumoto T, Nobukawa B, Kobayashi K, Watanabe M, Hosokawa A, Tomaru K, et al. Solitary polypoid xanthoma in the larynx. Histopathology. 1999;34(5):475-7. DOI: https://doi.org/10.1046/j.1365-2559.1999.0676d.x
Calonje E, Brenn T, Lazar A, McKee PH. McKee's pathology of the skin: with clinical correlations. 4th Edition. W.B. Saunders Company. 2012.
Perrone G, Zagami M, Casale M, Salvinelli F, Morini S, Rabitti C. Immunohistochemistry and differential diagnosis of a solitary flat laryngeal xanthoma: a case report. In Vivo. 2007;21(1):119-21.
Bell A, Shreenath AP. Xanthoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2024.
Balasaraswathy P, Kakkilaya BS, Shetty KM, Parameswaraiah S. A case of diabetes mellitus with xanthoma disseminatum. Indian J Dermatol. 2002;47(1):29-31.
Ghorpade A. Xanthoma disseminatum with koebnerized pearly penile lesions in an Indian man. Int J Dermatol. 2009;48(9):996-8. DOI: https://doi.org/10.1111/j.1365-4632.2008.04036.x
Varotti C, Bettoli V, Berti E, Cavicchini S, Caputo R. Xanthoma disseminatum: a case with extensive mucous membrane involvement. J Am Acad Dermatol. 1991;25(2 Pt 2):433-6. DOI: https://doi.org/10.1016/0190-9622(91)70223-O
Moloney JR. Xanthoma disseminatum: its otolaryngological manifestations. J Laryngol Otol. 1979;93(2):201-10. DOI: https://doi.org/10.1017/S0022215100086941
Mostafa KA, Takata T, Ogawa I, Ijuhin N, Nikai H. Verruciform xanthoma of the oral mucosa: a clinicopathological study with immunohistochemical findings relating to pathogenesis. Virchows Arch A Pathol Anat Histopathol. 1993;423(4):243-8. DOI: https://doi.org/10.1007/BF01606886
Tamiolakis P, Theofilou VI, Tosios KI, Sklavounou-Andrikopoulou A. Oral verruciform xanthoma: Report of 13 new cases and review of the literature. Med Oral Patol Oral Cir Bucal. 2018;23(4):e429-35. DOI: https://doi.org/10.4317/medoral.22342
Van Laer C, Hamans E, Neetens I, Van Marck E, Van Oosterom A, Van de Heyning P. Benign fibrous histiocytoma of the larynx: presentation of a case and review of the literature. J Laryngol Otol. 1996;110(5):474-7. DOI: https://doi.org/10.1017/S0022215100134024
Mabuchi H. Half a Century Tales of Familial Hypercholesterolemia (FH) in Japan. J Atheroscler Thromb. 2017;24(3):189-207. DOI: https://doi.org/10.5551/jat.RV16008
Feingold KR. Dyslipidemia in Patients with Diabetes. Endotext. South Dartmouth (MA): MDText.com, Inc. 2000.
Vera-Sempere F, Collado-Martín D, Vera-Sirera B. Solitary polypoid laryngeal xanthoma. Case Rep Otolaryngol. 2013;2013:967536. DOI: https://doi.org/10.1155/2013/967536
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