Metastasis to an odontogenic cyst: case report and review of literature

Authors

  • Shayan Sadeghi Department of Stomatology, Centre Hospitalier de l’Université de Montréal, Montreal, Canada
  • Claudya Aubry Department of Stomatology, Centre Hospitalier de l’Université de Montréal, Montreal, Canada
  • Christian Robin Department of Dentistry, Jewish General Hospital, McGill University, Montreal, Canada
  • Julien Ghannoum Department of Stomatology, Centre Hospitalier de l’Université de Montréal, Montreal, Canada

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20243514

Keywords:

Dentigerous cyst, Metastasis, Adenocarcinoma, Odontogenic cyst, Mandible

Abstract

Metastatic disease to the jawbone is relatively uncommon. However, its occurrence within a pre-existing odontogenic cyst or tumor is extremely rare. We present a case of a 61-year-old woman experiencing fatigue and nocturnal diaphoresis with an otherwise asymptomatic radiolucent lesion of the mandible. Radiographic features were suggestive of a benign odontogenic cyst. A biopsy revealed a metastatic nidus within the wall of a benign odontogenic cyst. Further investigations confirmed the presence of a primary pulmonary adenocarcinoma. Diagnosis of metastases to the orofacial region may be challenging because of their various clinical and radiographic features. Thorough histopathological analysis of any routine cystic tissue from the maxillofacial structures, even seemingly benign, is necessary to rule out more aggressive disease.

Metrics

Metrics Loading ...

References

Meyer I, Shklar G. Malignant Tumors Metastatic to Mouth and Jaws. Oral Surg Oral Med Oral Pathol. 1965;20:350-62.

Servato JP, de Paulo LF, de Faria PR, Cardoso SV, Loyola AM. Metastatic tumours to the head and neck: retrospective analysis from a Brazilian tertiary referral centre. Int J Oral Maxillofac Surg. 2013;42(11):1391-6.

Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity- pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.

Hirshberg A, Berger R, Allon I, Kaplan I. Metastatic tumors to the jaws and mouth. Head Neck Pathol. 2014;8(4):463-74.

Irani S. Metastasis to the Jawbones: A review of 453 cases. J Int Soc Prev Community Dent. 2017;7(2):71-81.

Andabak Rogulj A, Tomasovic Loncaric C, Muller D, Blivajs I, Andabak M, Vucicevic Boras V, et al. Solid malignant metastases in the jaw bones. Br J Oral Maxillofac Surg. 2018;56(8):705-8.

Johnson NR, Gannon OM, Savage NW, Batstone MD. Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 2014;5(1):9-14.

Jones AV, Craig GT, Franklin CD. Range and demographics of odontogenic cysts diagnosed in a

UK population over a 30-year period. J Oral Pathol Med. 2006;35(8):500-7.

Li N, Gao X, Xu Z, Chen Z, Zhu L, Wang J, et al. Prevalence of developmental odontogenic cysts in children and adolescents with emphasis on dentigerous cyst and odontogenic keratocyst (keratocystic odontogenic tumor). Acta Odontol Scand. 2014;72(8):795-800.

Bilodeau EA, Collins BM. Odontogenic Cysts and Neoplasms. Surg Pathol Clin. 2017;10:177-222.

Stoelinga PJW. The odontogenic keratocyst revisited. Int J Oral Maxillofac Surg. 2022;51(11):1420-3.

Polak K, Jedrusik-Pawlowska M, Drozdzowska B, Morawiec T. Odontogenic keratocyst of the mandible: A case report and literature review. Dent Med Probl. 2019;56(4):433-6.

Pogrel MA. The keratocystic odontogenic tumor. Oral Maxillofac Surg Clin North Am. 2013;25(1):21-30.

Welch RD, Hirsch SA, Davis RG. Melanoma with metastasis to an apical periodontal cyst. Oral Surg Oral Med Oral Pathol. 1985;59(2):189-93.

Chatterjee M, Balaraman K, McDermott P. Metastatic breast carcinoma discovered in a dentigerous cyst - a case report. Br Dent J. 2006;201(6):349-50.

Eichhorn W, Wehrmann M, Blessmann M, Pohlenz P, Blake F, Schmelzle R, et al. Metastases in odontogenic cysts: literature review and case presentation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4):582-6.

Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases. J Oral Pathol Med. 2011;40(10):733-8.

Zapala-Pospiech A, Wyszynska-Pawelec G, Adamek D, Tomaszewska R, Zaleska M, Zapala J. Malignant transformation in the course of a dentigerous cyst: a problem for a clinician and a pathologist. Considerations based on a case report. Pol J Pathol. 2013;64(1):64-8.

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209-49.

Nasim F, Sabath BF, Eapen GA. Lung Cancer. Med Clin North Am. 2019;103:463-73.

Gultekin SE, Senguven B, Isik Gonul I, Okur B, Buettner R. Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature. J Oral Maxillofac Surg. 2016;74:2007-e1-8.

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6:244-85.

Hutchinson BD, Shroff GS, Truong MT, Ko JP. Spectrum of Lung Adenocarcinoma. Semin Ultrasound CT MR. 2019;40:255-64.

Meza R, Meernik C, Jeon J, Cote ML. Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010. PLoS One. 2015;10:e0121323.

Kaplan I, Raiser V, Shuster A, Shlomi B, Rosenfeld E, Greenberg A, et al. Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations. Acta Histochem. 2019;121(8):151448.

Kandukuri SR, Lin F, Gui L, Gong Y, Fan F, Chen L, et al. Application of Immunohistochemistry in Undifferentiated Neoplasms: A Practical Approach. Arch Pathol Lab Med. 2017;141(8):1014-32.

Inamura K. Update on Immunohistochemistry for the Diagnosis of Lung Cancer. Cancers (Basel). 2018;10(3):72.

Rajendra Santosh AB. Odontogenic Cysts. Dent Clin North Am. 2020;64(1):105-19.

Dahl EC. Diagnosing inflammatory and non-inflammatory periapical disease. J Indiana Dent Assoc. 1991;70(6):22-6.

Terakado N, Shintani S, Nakashiro K, Hamakawa H. Malignant pleural mesothelioma metastasis to the mandible. Int J Oral Maxillofac Surg. 2004;33(8):798-800.

Thompson IO, Phillips VM, Kalan M. Metastatic squamous carcinoma manifesting as a periapical lesion. J Dent Assoc S Afr. 1992;47(11):481-3.

Poulias E, Melakopoulos I, Tosios K. Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report. J Med Case Rep. 2011;5:265.

Khalili M, Mahboobi N, Shams J. Metastatic breast carcinoma initially diagnosed as pulpal/periapical disease: a case report. J Endod. 2010;36(5):922-5.

Obenauf AC, Massague J. Surviving at a Distance: Organ-Specific Metastasis. Trends Cancer. 2015;1:76-91.

Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9(4):239-52.

Nicolson GL. Cancer progression and growth: relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis. Exp Cell Res. 1993;204(2):171-80.

Patel LR, Camacho DF, Shiozawa Y, Pienta KJ, Taichman RS. Mechanisms of cancer cell metastasis to the bone: a multistep process. Future Oncol. 2011;7(11):1285-97.

Yoneda T. Cellular and molecular basis of preferential metastasis of breast cancer to bone. J Orthop Sci. 2000;5(1):75-81.

Johnson RC, Augustin-Voss HG, Zhu DZ, Pauli BU. Endothelial cell membrane vesicles in the study of organ preference of metastasis. Cancer Res. 1991;51(1):394-9.

Nagy JA, Brown LF, Senger DR, Lanir N, Van de Water L, Dvorak AM, et al. Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta. 1989;948(3):305-26.

Downloads

Published

2024-11-26