Horse collar: a rare case report of Madelung disorder with review of literature
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20242050Keywords:
Madelung disease, Multiple symmetric lipomatosis, Liposuction, IntralipotherapyAbstract
Multiple symmetric lipomatosis is a rare disorder of fat metabolism which is characterized with bilateral symmetric and usually painless masses at various anatomical sites. Generally, the patient with this disease presents with cosmetic deformities. Extensive masses are known to have compressive symptoms like breathing difficulty and dysphagia. Imaging plays a pivotal role diagnosing this condition. Treatment options include both surgical and non-surgical modalities along with management of other metabolic disorders like diabetes and abstaining from alcohol intake. Recurrence is common. Given the uncommon nature of this illness and the debates surrounding its management, we report a case of multiple symmetric lipomatosis.
References
Gonzalezgarcia R, Rodriguez-Campo Francisco J, Sastre-Perez J, Muioz-Guerra Mario F. Benign symmetric lipomatosis (Madelung’s disease): Case reports and current management. Aesth Plast Surg. 2004;28(2).
Maximiano LF, Gaspar MT, Nakahira ES. Madelung disease (multiple symmetric lipomatosis). Autopsy Case Rep. 2018;8(3).
Nisoli E, Regianini L, Briscini L, Bulbarelli A, Busetto L, Coin A, et al. Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells. J Pathol. 2002;198(3):378-87.
Suresh Chandran C, Godge Y, Oak P, Ravat S. Madelung′s disease with myopathy. Annals of Indian Acad Neurol. 2009;12(2):131.
Plummer C, Spring PJ, Marotta R, Chin J, Taylor G, Sharpe D, et al. Multiple symmetrical lipomatosis-a mitochondrial disorder of brown fat. Mitochondrion. 2013;13(4):269-76.
Enzi G. Multiple symmetric lipomatosis. Medicine. 1984;63(1):56.
Schiltz D, Anker A, Ortner C, Tschernitz S, Koller M, Klein S, et al. Multiple symmetric lipomatosis: New Classification system based on the largest German patient cohort. Plast Reconstruct Surg. 2018;6(4).
Chen C-Y, Fang Q-Q, Wang X-F, Zhang M-X, Zhao W-Y, Shi B-H, et al. Madelung’s disease: Lipectomy or liposuction? BioMed Res Int. 2018;2018:1-8.
Enzi G, Inelmen EM, Baritussio A, Dorigo P, Prosdocimi M, Mazzoleni F. Multiple symmetric lipomatosis: A defect in adrenergic-stimulated lipolysis. J Clin Investig. 1977;60(6):1221-9.
Zielińska-Kaźmierska B, Lewicki M, Manowska B. Madelung disease. Adv Dermatol Allergol. 2015;5:400-3.
