Epidemiological study on the association between tobacco chewing and cigarette smoking in head and neck cancer patients, India
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20240062Keywords:
Head and neck cancer, Tobacco and non-tobacco chewing, Tobacco smoking and non-smokingAbstract
Background: Tobacco consumption, including smoking and chewing, is a significant risk factor for head and neck cancer in India. This study aims to examine the correlation between tobacco use and the causation of cancer among oral cancer patients.
Methods: We used the hospital-based cancer registry database at Savera cancer and multispeciality hospital in Patna. This is a retrospective analysis of head and neck cancer patients. The study was conducted from January 2019 to December 2022, involving patients aged 18-75 years. Histopathology Confirmed cases (n=691) of head and neck cancer were categorized into four groups: Only smoking tobacco (N=286), Only chewing tobacco (N=243), Smoking and chewing tobacco (N=139) and non-smoking and non-chewing (N=23), and examined.
Results: Among the random cases examined (n=691), the distribution was as follows: only smoking tobacco - 286 (41.4.0%), only chewing tobacco 243 (35.2%), Smoking and Chewing Tobacco 139 (20.1%), and non-smoking and non-chewing tobacco 23 (3.3%). Statistical analysis revealed a significant (p<0.005) association between tobacco consumption and oral cancer incidence.
Conclusions: Long-term exposure to chewing/non-chewing tobacco appears to play an important role in the development of head and neck cancer. There is an urgent need for preventive measures, including targeted interventions and public health campaigns, to mitigate the burden of cancer associated with it.
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References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Fung SY, Lam JW, Chan KC. Clinical utility of circulating Epstein-Barr virus DNA analysis for the management of nasopharyngeal carcinoma. Chin Clin Oncol. 2016;5(2):18.
WHO global report on trends in prevalence of tobacco smoking 2015?. Available at; https://apps.who.int/ iris/handle/10665/156262. Accessed on 20 February 2023.
Zhang LW, Li J, Cong X, Hu XS, Li D, Wu LL, Hua H, Yu GY, Kerr AR. Incidence and mortality trends in oral and oropharyngeal cancers in China, 2005-2013. Cancer Epidemiol. 2018;57:120-6.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Tobacco smoke and involuntary smoking. IARC Mono Eval Carcinog Risks Hum. 2004;83:1438.
Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008;371(9625):1695-709.
Vineis P, Alavanja M, Buffler P. Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst. 2004;96:99-106.
Hashibe M, Boffetta P, Zaridze D. Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev. 2006;15: 696-703.
Pavia M, Pileggi C, Nobile CG, Angelillo IF. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr. 2006;83:1126-34.
Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck. 2007;29:779-92.
Global adult tobacco survey GATS 2 India 2016-17. Available at: https://ntcp.mohfw.gov.in/assets/ document/surveys-reports. Accessed on 20 February 2023.
A Report on Cancer Burden in North Eastern States of India. Available at: https://www.ncdirindia.org/ All_Reports/NorthEast2021/resources/NE_Press_Release.pdf. Accessed on 20 February 2023.
Kumar A, Sharma A, Ahlawat B, Sharma S. Site specific effect of tobacco addiction in upper aerodigestive tract tumors: a retrospective clinicopathological study. Sci World J. 2014;2014: 460194.
