Amelanotic mucosal melanoma of the left sinonasal cavity: a case report

Authors

  • Yonanda Adi Pratama Department of Otorhinolaryngology Head and Neck Surgery, University of Gadjah Mada, Yogyakarta, Indonesia
  • I Komang Praba Department of Otorhinolaryngology Head and Neck Surgery, University of Gadjah Mada, Yogyakarta, Indonesia
  • Camelia Herdini Department of Otorhinolaryngology Head and Neck Surgery, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Sagung Rai Indrasari Department of Otorhinolaryngology Head and Neck Surgery, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Danu Yudistira Department of Otorhinolaryngology Head and Neck Surgery, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Yosephine Nina Department of Otorhinolaryngology Head and Neck Surgery, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20233583

Keywords:

Mucosal melanoma, Amelanotic melanoma, Head and neck, Sino-nasal

Abstract

Mucosal melanoma is rare type of melanoma accounted only 0.8-3.7% of melanoma. It defined as melanoma which occurs in mucous membrane, oral and nasal cavities, conjunctiva, genital sites, and rarely other mucosae. Head and neck melanoma accounted 50% among other sites. Recent studies, amelanotic subtype account 13.2% of all sino-nasal melanoma. Nasal cavity melanoma usually occurs on lateral nasal area especially in middle turbinate and inferior turbinate. Among other location, sino-nasal originated primary lesion was more deadly compared to other. We reported a case of amelanotic melanoma. 56 years old Asian Female presented with mass in left nose. The patient also complaint of recurring epistaxis, facial pain, epiphora, and blurred vision. After several follow up investigation, a diagnosis of amelanotic melanoma with orbit involvement was made. Subsequently patient underwent surgery for tumor removal. Although tumor has been removed, patient had to continue with adjuvant therapy for following month. Meticulous identifying and confirmation is an important factor which provide better understanding for the clinician in diagnosing. 

References

Spencer KR, Mehnert JM. Mucosal Melanoma: Epidemiology, Biology and Treatment. Cancer Treat Res. 2016;167:295-320.

Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway. Arch Pathol Lab Med. 2020;144(4):500-22.

Breik O, Sim F, Wong T, Nastri A, Iseli TA, Wiesenfeld D. Survival Outcomes of Mucosal Melanoma in the Head and Neck: Case Series and Review of Current Treatment Guidelines. J Oral Maxillofac Surg. 2016;74(9):1859-71.

Pontes FSC, de Souza LL, de Abreu MC, Fernandes LA, Rodrigues ALM, do Nascimento DM, et al. Sinonasal melanoma: a systematic review of the prognostic factors. Int J Oral Maxillofac Surg. 2020;49(5):549-57.

Hahn HM, Lee KG, Choi W, Cheong SH, Myung KB, Hahn HJ. An updated review of mucosal melanoma: Survival meta-analysis. Mol Clin Oncol. 2019;11(2):116-26.

Hasan S, Jamdar SF, Jangra J, Al Beaiji SM. Oral malignant melanoma: An aggressive clinical entity - Report of a rare case with review of literature. J Int Soc Prev Community Dent. 2016;6(2):176-81.

Castelhano L, Correia F, Raposo D, Campos A, Melo M, Pereira S, et al. Malignant tumors of the nose and paranasal sinuses: a retrospective review of a Portuguese cancer center’s experience. Head and Neck Tumors (HNT). 2021;11:10-7.

Dréno M, Georges M, Espitalier F, Ferron C, Charnolé A, Dréno B, Malard O. Sinonasal mucosal melanoma: A 44-case study and literature analysis. Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134(4):237-42.

Strazzulla LC, Li X, Zhu K, Okhovat JP, Lee SJ, Kim CC. Clinicopathologic, misdiagnosis, and survival differences between clinically amelanotic melanomas and pigmented melanomas. J Am Acad Dermatol. 2019;80(5):1292-8.

Verma R, Lokesh KP, Gupta K, Panda NK. Sinonasal amelanotic malignant melanoma – A diagnostic dilemma. Egyptian J Ear Nose Throat Allied Sci. 2015;16(3):275-8.

Xu QQ, Lai YZ, Huang ZL, Zeng ZY, Zhang YN, Ou RY, et al. Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities. Radiat Oncol. 2021;16(1):138.

Downloads

Published

2023-11-27

Issue

Section

Case Reports