Clinico-pathological study of sinonasal masses at a tertiary care hospital of southern Bihar

Garima Singh; Ankita Sinha; Ranbir K. Pandey; Deepak K. Gupta; Shashank Saurabh; Kumar Sanu

doi:10.18203/issn.2454-5929.ijohns20231809

Authors

Garima Singh Department of Otorhinolaryngology, Narayan Medical College and Hospital, Jamuhar, Bihar, India
Ankita Sinha Department of Otorhinolaryngology, Narayan Medical College and Hospital, Jamuhar, Bihar, India
Ranbir K. Pandey Department of Otorhinolaryngology, Narayan Medical College and Hospital, Jamuhar, Bihar, India
Deepak K. Gupta Department of Otorhinolaryngology, Narayan Medical College and Hospital, Jamuhar, Bihar, India
Shashank Saurabh Department of Otorhinolaryngology, Lal Hospital and Research Centre, Ranchi, Jharkhand, India
Kumar Sanu Department of Otorhinolaryngology, Madhubani Medical College and Hospital, Bihar, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20231809

Keywords:

Sinonasal masses, Sinonasal tract radiology, Histopathological examination

Abstract

Background: This study focuses on sino-nasal masses (SNMs) and their presentation with their radiological findings and corroboration with initial diagnosis and histopathological examination (HPE).

Methods: A prospective study conducted in total 62 patients with SNMs presenting between the period (September 2020 to October 2022) in medical college, southern Bihar. Patients were subjected to detailed history and battery of tests with all necessary investigations. Final diagnosis was concluded after HPE.

Results: Age distribution ranged from 10 to 64 years with mean age of 34.2 and M: F ratio of 1.14:1. Demography suggested predisposition in low socioeconomic strata (N=36; 58.06%). Majority fell in category of farmers (N=16; 25.8%) followed by housewives, laborers. Majority presented within a time frame of 1-2 years of onset of symptoms/appearance of the lesion (N=25;40.3%) followed by 6 months to 1-year. Most common presenting symptom was nasal obstruction (N=59;95.16%), followed by nasal discharge (n= 49, 79.03%). HPE concluded 45 samples (72.58%) as non-neoplastic, 15 samples (24.19%) as benign neoplastic (96.7%) and 2 as malignant neoplastic lesions (3.22%). In 58 out of 62 patients (93.54%) the clinical diagnosis was corroborated with HPE diagnosis.

Conclusions: Nasal polyps, the most common benign lesions and SCCs, the most common malignant lesion of SNT. Malignant lesions common in elderlies should be differentiated from non-malignant lesions. Due to similar presentation of diversified aetiology, a clinical and radiological evaluation is of prime for initial management. HPE remains the gold standard for final diagnosis and definitive management.

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References

Kirtsreesakul V. Update on Nasal Polyps: Etiopathogenesis. J Med Assoc Thai. 2005;88(12):1966-72.

Johansson L, Ākerlund AM Melen I, Holmberg K, Bende M. Prevalence of nasal polyps in adults: the Skovde population-based study. Ann Otol Rhinol Laryngol. 2003;112(7):625-9.

Sutar HB. Clinicopathological Study of Nasal Polypoidal Masses. Ann Int Med Dent Res. 2015;1(3):315-9.

Narvey VP, Saxena S, Saluja M. Clinico histopathological features of sinonasal lesions: an experience from a tertiary care hospital, central India. Int J Anatomy Radiol Surg. 2022;11(2):32-6.

Dasgupta A, Ghosh RN, Mukherjee C. Nasal polyps Histopathological spectrum. Indian J Otorhinolaryngol Head Neck Surg. 1997;49:32-7.

Bist SS, Varshney S, Baunthiyal V, Bhagat S, Kusum A. Clinico-pathological profile of sinonasal masses: An experience in tertiary care hospital of Uttarakhand. Natl J Maxillofac Surg. 2012;3(2):180-6.

Bakari A, Afolabi OA, Adoga AA, Ahmad BM. Clinicopathological profile of sinonasal masses: an experience in national ear care centre Kaduna, Nigeria. BMC Res Notes. 2010;3:186.

Zafar U, Khan N, Afroz N, Hasan SA. Clinicopathological study of non-neoplastic lesions of nasal cavity and paranasal sinuses. Indian J Pathol Microbiol. 2008;51(1):26-9.

Lathi A, Syed MM, Kalakoti P, Qutub D, Kishve SP. Clinico-pathological profile of sinonasal masses: a study from a tertiary care hospital of India. Acta Otorhinolaryngol Ital. 2011;31(6):372-7.

Agarwal P, Panigrahi R. Sinonasal Mass-a Recent Study of Its Clinicopathological Profile. Indian J Surg Oncol. 2017;8(2):123-7.

Deosthale N, Patil P, Khadakkar S, Garikapati P, Dhote K, Dhoke P, et al. A Clinicopathological Profile of Sino-nasal Masses at a Tertiary Care Hospital: A Descriptive Study. BJOHNS. 2021;29(2):133-9.

Rokade V, Shinde KJ, More GR. Clinicopathologicalprofile of Sinonasal masses-a tertiary care centre study in rural India. Int J Otorhinolaryngol Head Neck Surg. 2020;6:1821-6.

Hasan A, Nady M, Ibrahim A, Fayad S, Mohammed Y, Kandil A, et al. The utility of clinicopathological correlation of sinonasal masses in a tertiary hospital. J Evol Med Dent Sci. 2021;10(10):2278-4748.

Alabi BS, Afolabi OA, Omokanye HK, Dunmade AD, Ayodele SO. Clinical Presentation and Outcome of Sinonasal Tumors in a Nigerian Tertiary Hospital - 6-year Review. Niger Med J. 2017;58(3):92-5.

Diamantopoulos II, Jones NS, Lowe J. All nasal polyps Need histological examination: An audit-based appraisal of clinical practice. J Laryngol Otol. 2000;114:755-9.

Gupta A, Kapoor S, Saidha PK, Das P, Kumar A. Role of Histopathological Correlation in Cases of Sino-Nasal Masses: A Retrospective Analysis. Acta Scientif Otolaryngol. 2021;3(9):13-8.

Thakur M, Mishra A, Banjara H, Verma J. Clinicopathological study of sinonasal masses in Rural population of central India. Eur J Mol Amp. 2022;09(04):2515-8260.

Maheshwari A, Bansal A. Clinico-pathological spectrum of sinonasal masses: a tertiary care hospital experience. Int J Otorhinolaryngol Head Neck Surg. 2017;3(4):1015-9.

Bhattacharya J, Goswami BK, Banerjee A, Bhattacharyya R, Chakrabarti I, Giri A. A clinicopathological study of masses arising from sinonasal tract and nasopharynx in north Bengal population with special reference to neoplasms. Nepalese J ENT Head Amp. 2013;4(1).

Weymuller EA, Gal TJ. Neoplasms of the nasal cavity. In: Cummings CW, Flint PW, Harker LA. editors. Otolaryngology - Head and Neck Surgery. 4th ed. Mosby. 2005.

Lund VJ, Stammberger H, Nicolai P. European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinology. 2010;48(22):1-143.

Syrjänen KJ. HPV infections in benign and malignant sinonasal lesions. J Clin Pathol. 2003;56:174-81.

Califano J, Koch W, Sidransky D, Westra WH. Inverted sinonasal papilloma: a molecular genetic appraisal of its putative status as a precursor to squamous cell carcinoma. Am J Pathol. 2000;156(1)333-7.

Zimmer LA, Carrau RL. Neoplasms of the nose and paranasal sinuses. In: Bailey BJ, Johnson JT, Newland SD, editors. Head & Neck Surgery – Otolaryngology. 4thed. Philadelphia, PA: Lippincott, Williams& Wilkins. 2006.

Fasunla AJ, Lasisi AO. Sinonasal malignancies: a 10-year review in a tertiary health institution. J Natl Med Assoc. 2007;99:1407-10.

Pradhananga RB, Adhikari P, Thapa NM, A Shrestha, B Pradhan. Overview of nasal masses. J Inst Med. 2008;30:13-6.

Svane-Knudsen V, Jorgensen KE, Hansen O, Lindgren A, Marker P. Cancer of the nasal cavity and paranasal sinuses: a series of 115 patients. Rhinology. 1998;36(1):12-4.

Bolger WE, Parsons DS, Butzin CA. Paranasal sinus bony anatomic variations and mucosal abnormalities: CT analysis for endoscopic sinus surgery. Laryngoscope. 1991;101:56-64.

Stankiewicz JA, Chow JM. A diagnostic dilemma for chronic rhinosinusitis: Definition accuracy and validity. Am J Rhinol. 2002;16:199-202.