Magnitude and factors associated with sensorineural hearing loss in patients with HIV/AIDS attending tertiary hospital in northern zone Tanzania
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20231082Keywords:
Sensorineural hearing loss, Magnitude, Human immunodeficiency virusAbstract
Background: It is estimated that 20% to 50% of patients with HIV have hearing loss. 70% of people living with HIV worldwide are reported to be in Sub-Saharan Africa, making this region have a probable greater disease burden. However, hearing assessment is missing as a routinely conducted investigation in some treatment guidelines. The study aimed to determine the magnitude and factors associated with sensorineural hearing loss in patients with HIV/AIDS attending a tertiary hospital in Northern Tanzania.
Methods: This observational hospital-based cross-sectional study was conducted at the HIV outpatient clinics. The study population comprised children and adults with HIV/AIDS aged between 7 and 60 years old. A structured questionnaire and medical files were used to obtain hearing history and relevant medical information. Tympanometry and pure-tone audiometry was done.
Results: This study included 152 study participants. The median age was 46 (36.0 – 53.0) years. 109 (71.7%) were females, and 43 (28.3%) were males. The prevalence of sensorineural hearing loss (SNHL) was 34.9% (53 cases). Conductive hearing loss was 7.2% (11 cases,) and mixed hearing loss was 9.2% (14 cases). There was a statistically significant association between SNHL with nadir CD4 count, current viral load, and ART use duration of more than 10 years.
Conclusions: The magnitude of SNHL in patients with HIV/AIDS is alarmingly high. Hearing status should be assessed at baseline and follow-up course of HIV/AIDS management. This will also help analyse the probable impact of ART changes in the treatment guidelines.
References
Fokouo JVF, Vokwely JEE, Noubiap JJN, Nouthe BE, Zafack J, Minka Ngom ES, et al. Effect of HIV infection and highly active antiretroviral therapy on hearing function: A prospective case-control study from Cameroon. JAMA Otolaryngol - Head Neck Surg. 2015;141(5):436-41.
Kharsany AB, Karim QA. HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities. Open AIDS J. 2016;10:34-48.
Ensink RJH, Kuper H. Is hearing impairment associated with HIV? A systematic review of data from low- and middle-income countries. Trop Med Int Heal. 2017;22(12):1493-504.
Zhan Y, Fellows AM, Qi T, Clavier OH, Soli SD, Shi X, et al. Speech in noise perception as a marker of cognitive impairment in HIV infection. Ear and Hearing. 2018;39(3):548-54.
De Jong MA, Luder A, Gross M. Main aspects of peripheral and central hearing system involvement in unexplained HIV-related hearing complaints. Front Neurol. 2019;10(7).
Khoza K. Shangase: analysis of auditory manifestations in a group of adults with aids prior to antiretroviral therapy. Afr J Infect Dis. 2011;5(1):11-22.
Hong H, Budhathoki C, Farley JE. Increased risk of aminoglycoside-induced hearing loss in MDR- TB patients with HIV coinfection. Int J Tuberc Lung Dis. 2018;22(6):2018:667-74.
Mcdaid D, Park A, Chadha S. Estimating the global costs of hearing loss. Int J Audiol. 2021;60(3):162-70.
Ongulo BA, Oburra HO. Hearing disorders in HIV positive adult patients not on anti-retroviral drugs at Kenyatta National Hospital. East Afr Med J. 2010;87(9):385-8.
Chao CK, Czechowicz JA, Messner AH, Alarco J. High Prevalence of Hearing Impairment in HIV-Infected Peruvian Children. Otolaryngol– Head Neck Surg. 2012;146(2):259-65.
Khoza-Shangase K. Highly active antiretroviral therapy : Does it sound toxic? J Pharm Bioall Sci. 2011;1:142-53.
Fasunla AJ, Ogunkeyede SA, Afolabi SO. Hearing Loss Among Adolescents on Antiretroviral Therapy: a Need for Periodic Hearing Assessment. Ann Ibadan Postgrad Med. 2019;17(1):14-8.
Van Der Westhuizen Y, Swanepoel DW, Heinze B, Hofmeyr LM. Auditory and otological manifestations in adults with HIV/AIDS. Int J Audiol. 2013;52(1):37-43.
Schouten JT, Lockhart DW, Rees TS, Collier AC, Marra CM. A prospective study of hearing changes after beginning zidovudine or didanosine in HIV-1 treatment-naïve people. BMC Infect Dis. 2006;6(ddI):1-6.
Matas CG, Angrisani RG, Magliaro FC, Segurado AA. Audiological manifestations in HIV-positive adults. Clinics. 2014;69(7):469-75.
Gentile C, Giannella A, Cristina F, Magliaro L, Segurado A. Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy. Braz J Otorhinolaryngol. 2018;84(5):574-82.
Makau SM, Ongulo BA, Mugwe P. The pattern of hearing disorders in hiv positive patients on anti - retrovirals at kenyatta national hospital. East Afr Med J. 2010;87(10):425-9.
Cohen BE, Durstenfeld A, Roehm PC. Viral Causes of Hearing Loss : A Review for Hearing Health Professionals. Trends in Hearing 2014;18:1-17.
Hurtado Navarro I, Alastrue I, Del Amo J, Santos C, Ferreros I, Tasa T, Pérez-Hoyos S. Differences between women and men in serial HIV prevalence and incidence trends. Eur J Epidemiol. 2008;23(6):435-40.
Adabi M, Adebayo OM, Adekanmbi V, Adeyinka DA, Afzal S. Mapping age ‑ and sex ‑ specific HIV prevalence in adults in sub ‑ Saharan Africa , 2000 – 2018. BMC Med. 2022;1-24.
Article O. Hearing loss in children with HIV / AIDS Perda auditiva em crianças com HIV / AIDS. 2013;25(1):513-20.
Kakuda TN. Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity. Clin Ther. 2000;22(6):685-708.
Massawe ER, Moshi N, Kimario J, Liyombo E, Kishevo P. Patterns of Hearing Loss Among HIV Adult Patients Attending Clinic at Tertiary Hospital, Tanzania. Acta Scientific Otolaryngol. 2022;4(4):10-20.
Fokouo JVF, Vokwely JEE, Noubiap JJN, Nouthe BE, Zafack J, Stéphanie E, et al. Effect of HIV Infection and Highly Active Antiretroviral Therapy on Hearing Function A Prospective Case-Control Study From Cameroon. JAMA Otolaryngol Head Neck Surg. 2015;141(5):436-41.
Miranda K, Pace D a, Cintron R, Rodrigues JCF, Fang J, Smith A, et al. Auditory impairement in HIV-infected patients in Tanzania. Natl Inst Heal Public Access. 2011;76(6):1358-75.
Simdon J, Watters D, Bartlett S, Connick E. Ototoxicity associated with use of nucleoside analog reverse transcriptase inhibitors: a report of 3 possible cases and review of the literature. Clin Infect Dis. 2001;32(11):1623-7.
