Unusual sinonasal mass clinically mimicking malignancy


  • Shalvi N. Hajare Department of ENT, Sanjeevan Medical foundation ENT PG Training Institute, Miraj, Maharashtra, India
  • Gautam S. Purohit Department of ENT, Sanjeevan Medical foundation ENT PG Training Institute, Miraj, Maharashtra, India
  • Vishal K. Magdum Department of ENT, Sanjeevan Medical foundation ENT PG Training Institute, Miraj, Maharashtra, India
  • Sachin S. Nilakhe Department of ENT, B.V. (D.T.U), Medical College and Hospital, Sangli, Maharashtra, India




Central giant cell granuloma, Multinucleated giant cells, Surgical excision, Sinonasal mass


Central giant cell lesion is a non-neoplastic proliferation, usually asymptomatic, of unknown aetiology. This case report describes the diagnosis and treatment for a maxillary central giant cell lesion. We report a case of a 30-year-old lady with a central giant cell granuloma (CGCG) who presented with a history of right-side nasal blockage, swelling and pain in the right side of the cheek, proptosis of the right eye, occasional blurred vision for one month. Images and histopathology examinations confirmed the diagnosis. The patient underwent tumour resection through the endoscopic endonasal approach successfully without any postoperative complication, there was no recurrence within a year of follow up and its histopathological analysis was consistent with a CGCG. Histopathological examination of the mass confirmed as CGCG. Complete excision of right sinonasal mass achieved by right endoscopic sinus surgery through modified Denker’s approach. As CGCG is a non-neoplastic lesion of unknown aetiology, histopathology is necessary for definitive diagnosis. Treatment can vary depending on the extension of the tumour.


Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6:159-75.

Waldron CA, Shafer WG. The central giant cell reparative granuloma of the jaws: an analysis of 38 cases. Am J Clin Pathol. 1966;45:437-47.

Barnes L, Eveson JW, Reichart P, Sidransky D (eds), Pathology and genetics of head and neck tumours. In: Kleihues P, Sobin LH (eds), World Health Organization classification of tumours. Lyon, France: IARC Press. 2005.

Spraggs PD, Roth J, Young-Ramsaran J, Goodwin WJ. Giant cell reparative granuloma of the maxilla. Ear Nose Throat J. 1997;76:445-9.

Sidhu MS, Parkash H, Sidhu SS. Central giant cell granuloma of jaws-review of 19 cases. Br J Oral Maxillofac Surg. 1995;33:43-6.

Raizada RM, Khan N, Mohan V, Gupta VC. Central giant cell granuloma of the maxilla: a case report. J Indian Dent Assoc. 1984;56:111-3.

Curtis NJ, Walker DM. A case of aggressive multiple metachronous central giant cell granulomas of the jaws: differential diagnosis and management options. Int J Oralmaxillofac Surg. 2005;34:806-8.

Chuong R, Kaban LB, Kozakewich H, PerezAtayde A. Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg. 1986;44(9):708-13.

Gungormus M, Akgul HM. Central giant cell granuloma of the jaws: a clinical and radiological study. J Contemp Dent Pract. 2003;4(3):87-97.

Patloth T, Sharada RJ. Surgically treated central giant cell granuloma in a six-year-old child: A case report. Int J Clin Pediatr Dent. 2013;6(2):146-49.

Chandrasekhar M, Charitha M, Thabusum A, Chandrasekhar G, Jyothirmai. A rareity of central giant cell granuloma. Int J InnovSci Res Technol. 2019;4(4):1029-32.

Harris M. Central giant cell granulomas regress with calcitonin therapy. Br J Oral Maxillofac Surg. 1993;31:89-94.

Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB. Antiangiogenic therapy with interferon-alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002;60:1103-11.

Davis JP, Archer DJ, Fisher C, Wimabawansa SJ, Baldwin D. Multiple recurrent giant cell lesions associated with a high circulating level of parathyroid hormone-related peptide in a young adult. Br J Oral Maxillofac Surg. 1991;29:102-5.

Walstad WR, Fields T, Schow SR, McKenna SJ. Expansile lesion of the anterior maxilla. J Oral Maxillofac Surg. 1999;57:595-9.






Case Reports