Role of GeneXpert in diagnosis of rifampicin resistant tuberculosis in patients with cervical lymphadenopathy
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20230105Keywords:
Tuberculosis, Gene Xpert, Rifampicin resistant, HPE, AFB culture, ZN stainingAbstract
Tuberculosis is one of the most common causes for cervical lymphadenopathy apart from distant metastasis and lymphoma. Early diagnosis of this disease reduces the patient’s morbidity by initiating early course of Antitubercular treatment with complete resolution of disease. Hence, for diagnosis of this condition we are searching for a modality which can give results in shorter period of time, which is more sensitive, specific and most important easier to perform. Gene Xpert is one such modality which fits into these criteria. In our case series, we are aiming to study the role of Gene Xpert in diagnosis of rifampicin resistant tuberculosis in patients with cervical lymphadenopathy. In our study, excisional biopsy from cervical region was done in 30 cases and were sent for acid fast bacilli culture, Ziehl Neelsen staining and GeneXpert studies, histopathological examination and results were analyzed.
References
Khanna R, Sharma AD, Khanna S, Kuma M, Shukla RC. Usefulness of ultrasonography for the evalusation of cervical lymphadenopathy. World J Surg Oncol. 2011;9:1-4.
World Health Organisation. Rapid Implementation of the Xpert MTB/RIF Diagnostic Test, World Health Organisation. 2011. Available at: http://whqlibdoc.who.int/publications/2011/9789241501569_eng.pdf. Accessed on 12 November 2022.
Lawn SD, Nicol M. Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance. Fut Microbiol. 2011;6(9):1067-821.
Hillemann D, Ru:sch-Gerdes S, Boehme C, Richter E, Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system. J Clin Microbiol. 2011;49(4):1202-5.
Iram S, Zeenat A, Hussain S, Yusuf NW, Aslam M. Rapid diagnosis of tuberculosis using Xpert MTB/RIF assay – report from a developing country. Pak J Med Sci. 2015;31(1):105-10.
Agrawal M, Bajaj A, Bhatia V, Dutt S. Comparative study of GeneXpert with ZN stain and culture in samples of suspected pulmonary tuberculosis. J Clin Diagnost Res. 2016;10(50):9-12.
Guenaoui K, Harir N, Ouardi A, Zeggai S, Sellam F, Bekri F, et al. Use of GeneXpert Mycobacterium tuberculosis/rifampicin for rapid detection of rifampicin resistance Mycobacterium tuberculosis strains of clinically suspected multi-drug resistance tuberculosis cases. Ann Transl Med. 2016;4(9):168-73.
