Role of GeneXpert in diagnosis of rifampicin resistant tuberculosis in patients with cervical lymphadenopathy


  • Maya Singh Department of ENT, Maulana Azad Medical College, New Delhi, India
  • Sakshi Negi Department of ENT, Maulana Azad Medical College, New Delhi, India
  • Sonali Tyagi Department of ENT, Chacha Nehru Bal Chikitsalaya, New Delhi, India
  • Abhijeet Makwana Department of Head and Neck Surgery, IFHNOS, Nathalal Parekh Cancer Hospital, Rajkot, Gujarat, India



Tuberculosis, Gene Xpert, Rifampicin resistant, HPE, AFB culture, ZN staining


Tuberculosis is one of the most common causes for cervical lymphadenopathy apart from distant metastasis and lymphoma. Early diagnosis of this disease reduces the patient’s morbidity by initiating early course of Antitubercular treatment with complete resolution of disease. Hence, for diagnosis of this condition we are searching for a modality which can give results in shorter period of time, which is more sensitive, specific and most important easier to perform. Gene Xpert is one such modality which fits into these criteria. In our case series, we are aiming to study the role of Gene Xpert in diagnosis of rifampicin resistant tuberculosis in patients with cervical lymphadenopathy. In our study, excisional biopsy from cervical region was done in 30 cases and were sent for acid fast bacilli culture, Ziehl Neelsen staining and GeneXpert studies, histopathological examination and results were analyzed.


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Case Series