Advanced stage nasopharyngeal carcinoma in children

Authors

  • Anisa Haqul Khoiria Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Yogyakarta, Indonesia http://orcid.org/0000-0001-6674-078X
  • Sagung Rai Indrasari Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Camelia Herdini Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
  • Danu Yudistira Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20223049

Keywords:

Nasopharyngeal carcinoma, Malignancy, Children, Pediatric

Abstract

Nasopharyngeal carcinoma (NPC) is common in adult and elderly population, however, the incidence among children is still very low worldwide. Due to its rarity and non-specific clinical presentation, the diagnosis in children is often delayed and misinterpreted. The difficulty in reaching the final diagnosis was related to its hidden anatomical location, raising challenges in performing endoscopy and biopsy in children to obtain the precise histopathologic feature. We reported two cases on nasopharyngeal carcinoma in children with two different peculiar complaints. The first patient was 12 years old boy who complained of multiple recurrent unilateral masses on the left neck and history of nosebleeds with an unknown history of the previous histopathology features of the neck masses obtained by complete surgical neck mass removal beforehand. The second patient was 15 years old boy with main complaint of chronic headache, accompanied by doubled vision with apparent family history of malignancy, particularly nasopharyngeal carcinoma. Based on the history of illness, physical examination, imaging, and histopathology, we concluded that both patients were diagnosed with advanced stage nasopharyngeal carcinoma with different types of histopathologic feature.

Author Biographies

Anisa Haqul Khoiria, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Yogyakarta, Indonesia

Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Yogyakarta, Indonesia.

Sagung Rai Indrasari, Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Oncology Division Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito general hospital, Yogyakarta, Indonesia.

Camelia Herdini, Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Oncology Division Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito general hospital, Yogyakarta, Indonesia.

Danu Yudistira, Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Oncology Division Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, University of Gadjah Mada, Dr. Sardjito general hospital, Yogyakarta, Indonesia.

References

González-motta A, González G, Bermudéz Y, Maldonado MC, Castañeda JM, Lopéz D, et al. Paediatric Nasopharyngeal Cancer: Case Report and Review of the Literature. Cureus. 2016;8(2):1-9.

Claude L, Jouglar E, Duverge L, Orbach D. Update in paediatric nasopharyngeal undifferentiated carcinoma. Br J Radiol. 2019;92:1-10.

Santosh KS, Smrutipragnya S, Jatindra NM, Jasahree C. Nasopharyngeal carcinoma among pediatric patients in non-endemic region: our experience in tertiary care teaching hospital in Eastern India. Egypt Pediatr Assoc Gazette. 2020;68(23):1-6.

Setiani L, Kurnia B, Karnita Y. Characteristics of nasopharyngeal carcinoma in children and adolescents in Dr. Zainoel Abidin general hospital Banda Aceh. Int J Nasopharyng Carcinoma. 2019;1(3):93-6.

Ben-Ami T, Kontny U, Surun A, Brecht IB, Almaraz RL, Dragomir M, et al. Nasopharyngeal carcinoma in children and adolescents: the expert/partner diagnostic and therapeutic recommendations. Pediatr Blood Cancer. 2021;68(4):1-11.

Hu S, Xu X, Xu J, Xu Q, Liu S. Prognostic factors and long-term outcomes of nasopharyngeal carcinoma in children and adolescents. Pediatric Blood Cancer. 2013;60(7):1122-7.

Barrett D, Ploner A, Chang E, Liu Z, Zhang C, Liu Q, et al. Past and recent salted fish and preserved food intakes are weakly associated with nasopharyngeal carcinoma risk in adults in Southern China. J Nutrit. 2019;149(9):1596-605.

Küpeli S, Varan A, Büyükpamukçu M, Oguz S, Özgen B, Akçören Z. Pediatric nasopharyngeal carcinoma. Pediatr Blood Cancer. 2009;53(6):1165-6.

Roganović J, Matijašić N, Maurizio M. Pediatric advanced stage nasopharyngeal carcinoma - case report. Acta Medica Academica. 2015;44(2):186-90.

Liu W, Tang Y, Gao L, Huang X, Luo J, Zhang S, et al. Nasopharyngeal carcinoma in children and adolescents-a single institution experience of 158 patients. Radiat Oncol. 2014;9(1):1-7.

Jackson D. Evaluation and management of pediatric neck masses. Phys Assistant Clinic. 2018;3(2):245-69.

Mouden K. Nasopharyngeal carcinoma in childhood: analysis of a series of 64 patients treated with combined chemotherapy and radiotherapy. Oncol Int J. 2018;9(2):1-7.

Vianna P, Ferreira C, Neto P, Martines B. Cervical lymphadenopathy in childhood: nasopharyngeal carcinoma as a challenging diagnosis. Autopsy Case Rep. 2012;2(4):53-60.

Green D. Long-term complications of treatment of children and adolescents with cancer: Cardiovascular complications and childhood cancer. Pediatr Blood Cancer. 2005;44(7):583.

Cheuk D, Billups C, Martin M, Roland C, Ribeiro R, Krasin M, et al. Prognostic factors and long-term outcomes of childhood nasopharyngeal carcinoma. Cancer. 2010;117(1):197-206.

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Published

2022-11-24

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Section

Case Reports