Published: 2022-11-24

Plasma cell mucositis masquerading as squamous cell carcinoma- a surgical dilemma: a rare case report and review of literature

Ashish Gopal, Maya Singh, Ishwar Singh, Sharmana Mandal


Plasma cell mucositis is a rare, idiopathic, multifocal, benign proliferative disorder affecting upper aerodigestive tract. It is a very rare condition and less than 50 cases reported in literature. A 62 years old female patient reported with complaints of oral discomfort, superficial erosive ulceration on the tongue, and burning sensation on eating food for last 2 years. Initially, Incisional biopsy of the involved mucosal area confirmed the diagnosis of well differentiated squamous cell carcinoma for which hemi-glossectomy was done. However histopathological examination submitted revealed a hyperplastic epithelium with a dense infiltrate of mature polyclonal plasma cells in the superficial layer of lamina propria, for which plasma cell mucositis was made a diagnosis. Plasma cell mucositis is a diagnosis of exclusion, to be differentiated from other infective, reactive, autoimmune, allergic and neoplastic disorders with plasma cell infiltrates. Management includes topical, intralesional, systemic corticosteroids and debulking procedures. Regular follow-up is essential due to the possibility of its clinical persistence and chances of malignant transformation.


Plasma cell mucositis, Squamous cell carcinoma, Plasmacytosis

Full Text:



Ferreiro JA, Egorshin EV, Olsen KD, Banks PM, Weiland LH. Mucous membrane plasmacytosis of the upper aerodigestive tract. A clinicopathologic study. Am J Surg Pathol. 1994;18(10):1048-53.

Zoon JJ. Chronic benign circumscript plasmocytic balanoposthitis. Dermatologica. 1952;105:1-7.

Puvanendran M, Lieder A, Issing W. Plasma cell mucositis of oro-and hypopharynx: a case report. Case Rep Otolaryngol. 2012;2012.

Solomon LW, Wein RO, Rosenwald I, Laver N. Plasma cell mucositis of the oral cavity: Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:853-60.

Pepper T, Shekar K, Singh M, Brennan PA. Squamous cell carcinoma arising in mucosal plasmacytosis. Br J Oral Maxillofac Surg. 2010;48:208-10.

White JW, Jr, Olsen KD, Banks PM. Plasma cell orificial mucositis. Report of a case and review of the literature. Arch Dermatol. 1986;122:1321-4.

Aiba S, Tagami H. Immunoglobulin‐producing cells in plasma cell orificial mucositis. J Cutan Pathol. 1989;16(4):207-10.

Bharti R, Smith DR. Mucous membrane plasmacytosis: a case report and review of the literature. Dermatol Online J. 2003;9(5):15-5.

Smith ME, Crighton AJ, Chisholm DM, Mountain RE. Plasma cell mucositis: a review and case report. J Oral Pathol Med. 1999;28(4):183-6.

Khan NA, McKerrow WS, Palmer TJ. Mucous membrane plasmacytosis of the upper aerodigestive tract. A case report with effective treatment. J Laryngol Otol. 1997;111(3):293-5.

Iseri M, Ozturk M, Ulubil SA. Synchronous presentation of extramedullary plasmacytoma in the nasopharynx and the larynx. Ear Nose Throat J. 2009;88(11):E9-12.

Galieni P, Cavo M, Pulsoni A, Avvisati G, Bigazzi C, Neri S et al. Clinical outcome of extramedullary plasmacytoma. Haematologica. 2000;85(1):47-51.

Straetmans J, Stokroos R. Extramedullary plasmacytomas in the head and neck region. Eur Arch Oto-Rhino-Laryngol. 2008;265(11):1417-23.

Gasparro R, Adamo D, Masucci M, Sammartino G, Mignogna MD. Use of injectable platelet‐rich fibrin in the treatment of plasma cell mucositis of the oral cavity refractory to corticosteroid therapy: A case report. Dermatolo Therap. 2019;32(5):e13062-2

Galvin S, Bowe C, Regan EM, Conlon N, Flint SR, Healy CM. Circumorificial plasmacytosis/plasma cell orificial mucositis: a case series and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(3):e77-81.