Rosai Dorfman disease: a case report with nodal involvement

Authors

  • Silky Silky Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Vishwambhar Singh Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Rajesh Kumar Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Ashvanee Kumar Chaudhary Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Shishupal Yadav Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Deepak Kumar Gupta Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Arpit Goyal Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Ram Raj Yadav Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Rahul Rahul Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Akshat Panday Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20220480

Keywords:

Emperipolesis, Rosai Dorfman, Histiocytosis, CD68, Corticosteroids

Abstract

Rosai Dorfman disease is characterised by sinus histiocytosis with massive lymphadenopathy. Here, we present a case report of 33-year female with low grade fever and multiple swellings of variable size in cervical region. Laboratory examinations showed erythrocyte sedimentation rate to be increased up to 40 mm / hour. Histopathological examination revealed a number of histiocytes containing lymphocytes and few plasma cells in their cytoplasm showing emperipolesis of plasma cells and lymphocytes. Immunohistochemistry showed positivity for CD68 with marked sinus expansion by histiocytic cells and emperipolesis. Treatment with tapering dose of systemic corticosteroids over 1 month gave excellent results.

Author Biographies

Silky Silky, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident,Otorhinolaryngology

Vishwambhar Singh, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Associate Professor, Otorhinolaryngology

Rajesh Kumar, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Professor & Head, Otorhinolaryngology

Ashvanee Kumar Chaudhary, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Senior Resident,Otorhinolaryngology

Shishupal Yadav, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident,Otorhinolaryngology

Deepak Kumar Gupta, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Senior Resident,Otorhinolaryngology

Arpit Goyal, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident,Otorhinolaryngology

Ram Raj Yadav, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident,Otorhinolaryngology

Rahul Rahul, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident,Pathology

Akshat Panday, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident,Otorhinolaryngology

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Published

2022-02-24

Issue

Vol. 8 No. 3 (2022): March 2022

Section

Case Reports