Hearing impairment in patients of renal failure


  • Joshna Thakur Department of ENT, NSCB Medical College, Jabalpur, Madhya Pradesh, India http://orcid.org/0000-0002-3187-4371
  • Kavita Sachdeva Department of ENT, NSCB Medical College, Jabalpur, Madhya Pradesh, India




Hearing loss, Creatinine level, Renal failure, Dialysis, Ototoxic drugs


Background: Kidney diseases are emerging public health problems in developing countries. A common complication of renal failure is sensorineural hearing loss which is leading to poor quality of life. The aim of the study was to determine the prevalence of hearing loss in renal failure patients and to see the correlation of dialysis, ototoxic drugs, and creatinine levels.

Methods: This observational study was conducted at the department of otorhinolaryngology, tertiary care center, Jabalpur (Madhya Pradesh) for a period of 18 months i.e.; from March 2019 to August 2020. 70 patients with renal failure were registered for study. In all patients hematological tests include hemoglobin, urea, creatinine, random blood sugar, serum electrolytes and pure tone audiometry was done.  

Results: Out of 70 patients, 51 patients (72.9%) of renal failure had sensorineural hearing loss. Hypertension and diabetes mellitus as comorbidity play important role in hearing loss in renal failure patients. Acoustic reflex was absent in 14.3% of cases which signifying a profound hearing loss and these patients had creatinine level above 6 mg/dl.

Conclusions: Senorineural hearing loss is more prevalent in renal failure patients. Significant association was present between raised creatinine level and sensorineural hearings loss. Diabetes mellitus and hypertension were the common comorbidities that have a significant role in hearing loss in renal failure patients. All patients having renal failure have a risk of developing sensorineural hearing loss. So, these patients should be kept under follow up by doing regular pure tone audiometry and taking preventive measures, so that the hearing loss doesn't occur.

Author Biographies

Joshna Thakur, Department of ENT, NSCB Medical College, Jabalpur, Madhya Pradesh, India

Otorhinolaryngology and head and neck surgery

Kavita Sachdeva, Department of ENT, NSCB Medical College, Jabalpur, Madhya Pradesh, India

Otorhinolaryngology and head and neck surgery


GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-544.

Bazzi C, Venturini CT, Pagani C, Arrigo G, D'Amico G. Hearing loss in short- and long-term haemodialysed patients. Nephrol Dial Transplant. 1995;10(10):1865-8.

Ozturan O, Lam S. The effect of hemodialysis on hearing using pure-tone audiometry and distortion-product otoacoustic emissions. ORL J Otorhinolaryngol Relat Spec. 1998;60(6):306-13.

Bergstrom L, Jenkins P, Sando I, English GM. Hearing loss in renal disease: clinical and pathological studies. Ann Otol Rhinol Laryngol. 1973;82(4):555-76.

Arnold W. Inner ear and renal diseases. Ann Otol Rhinol Laryngol Suppl. 1984;112:119-24.

Irwin J. Basic anatomy and physiology of the ear. In: Newton VE, Vallely PJ, eds. Infection and Hearing Impairment. Chichester, UK: John Wiley and Sons; 2006: 8-13.

Cosgrove D, Samuelson G, Meehan DT, Miller C, McGee J, Walsh EJ, et al. Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome. Hear Res. 1998;121(1):84-98.

Pirodda A, Cicero AF, Borghi C. Kidney disease and inner ear impairment: a simpler and closer pathogenic analogy?. Intern Emerg Med. 2012;7(2):93-5.

Henrich WL, Thompson P, Bergstrom LV, Lum GM. Effect of dialysis on hearing acuity. Nephron. 1977;18(6):348-51.

Charachon R, Ribes V, Cordonnier D. Deafness due to renal failure. Clinicopathological study (author's transl). Ann Otolaryngol Chir Cervicofac. 1978;95(3):179-203.

Meena RS, Aseri Y, Singh BK, Verma PC. Hearing loss in patients of chronic renal failure: a study of 100 cases. Indian J Otolaryngol Head Neck Surg. 2012;64(4):356-9.

Stavroulaki P, Nikolopoulos TP, Psarommatis I, Apostolopoulos N. Hearing evaluation with distortion-product otoacoustic emissions in young patients undergoing haemodialysis. Clin Otolaryngol Allied Sci. 2001;26(3):235-42.

Davies RA. Handbook of Clinical Neurology. Netherland: Elsevier; 2016.

Gierek T, Markowski J, Kokot F, Paluch J, Wiecek A, Klimek D. Electrophysiological examinations (ABR and DPOAE) of hearing organ in hemodialysed patients suffering from chronic renal failure. Otolaryngol Pol. 2002;56(2):189-94.

Pandey S, Gore G, Valame D, Mehta K. Audiometric profile in patients with chronic renal failure. J Otolaryngol Head Neck Surg. 2011;40(2):131-6.

Kligerman AB, Solangi KB, Ventry IM, Goodman AI, Weseley SA. Hearing impairment associated with chronic renal failure. Laryngoscope. 1981;91(4):583-92.

Mirahmadi MK, Vaziri ND. Hearing loss in end-stage renal disease - effect of dialysis. J Dial. 1980;4(4):159-65.

Renda R, Renda L, Selçuk ÖT, Eyigör H, Yılmaz MD, Osma Ü. Cochlear sensitivity in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis. Int J Pediatr Otorhinolaryngol. 2015;79(12):2378-83.

Bawa AG, Singh G, Uzair G, Garg S, Kaur J. Pattern of hearing loss among chronic kidney disease patients on haemodialysis. Int J Med Res Prof. 2017;3:193-6.

Wu KL, Shih CP, Chan JS, Chung CH, Lin HC, Tsao CH, et al. Investigation of the relationship between sensorineural hearing loss and associated comorbidities in patients with chronic kidney disease: A nationwide, population-based cohort study. PLoS One. 2020;15(9):238913.






Original Research Articles