Published: 2021-10-26

Sinonasal teratocarcinosarcoma: a case report

Thottukadavil S. Priya, Chakramakal Joseph Andrews, S. Suresh Kumar, S. Divya


Sinonasal teratocarcinosarcoma (TCS) is a very rare malignant neoplasm of sinonasal tract with intermixed teratomatous, carcinomatous and sarcomatous elements. While the diagnosis is largely based on tissue analysis and immunohistochemistry, the mode of management demands further study. Surgical resection with or without chemotherapy and radiation therapy is currently the most accepted treatment regimen. Locally aggressive, while also associated with metastatic lesions, SNTCS is not easily resectable owing to its location and possible intracranial extension. Due to its aggressive nature over one-third of TCS tend to recur leading to treatment failure with a mean survival time of 1.9 years. Possible differentials include squamous cell carcinoma, olfactory neuroblastoma, adenocarcinoma, malignant mixed tumor of salivary gland type, undifferentiated carcinoma, malignant craniopharyngioma, mucoepidermoid carcinoma, transitional carcinoma of Schneiderian type and adenosquamous carcinoma. In this report, we present a case of TCS in a 55 years old male patient who presented to us with complaints of hyposmia, blurring of vision, diplopia and epiphora.


Chemotherapy, Sinonasal tract, Teratocarcinosarcoma, Telecanthus

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Chao KK, Eng TY, Barnes J, Dahiya R. Sinonasal teratocarcinosarcoma. Am J Clin Oncol. 2004;27(1):29-32.

Ogawa T, Ikeda K, Watanabe M, Satake M, Oshima T, Suzuki N, et al. A case report of sinonasal teratocarcinosarcoma. Tohoku J Exp Med. 2000;190(1):51-9.

Salem F, Rosenblum MK, Jhanwar SC, Kancherla P, Ghossein RA, Carlson DL. Teratocarcinosarcoma of the nasal cavity and paranasal sinuses: report of 3 cases with assessment for chromosome 12p status. Hum Pathol. 2008;39(4):605-9.

Shanmugaratnam K, Kunaratnam N, Chia KB, Chiang GS, Sinniah R. Teratoid carcinosarcoma of the paranasal sinuses. Pathology. 1983;15(4):413-9.

Heffner DK, Hyams VJ. Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. Cancer. 1984;53(10):2140-54.

Carrizo F, Daboin K, Neto AG, Luna MA. Pharyngeal teratocarcinosarcoma: review of the literature and report of two cases. Ann Diagn Pathol. 2006;10(6):339-42.

Wei S, Carroll W, Lazenby A, Bell W, Lopez R, Said N. Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome. Ann Diagn Pathol. 2008;12(6):415-25.

Pai SA, Naresh KN, Masih K, Ramarao C, Borges AM. Teratocarcinosarcoma of the paranasal sinuses: a clinicopathologic and immunohistochemical study. Hum Pathol. 1998;29(7):718-22.

Takasaki K, Sakihama N, Takahashi H. A case with sinonasal teratocarcinosarcoma in the nasal cavity and ethmoid sinus. Eur Arch Otorhinolaryngol. 2006;263(6):586-91.

Devgan BK, Devgan M, Gross CW. Teratocarcinoma of the ethmoid sinus: review of literature plus a new case report. Otolaryngology. 1978;86(5):689-95.

Fernández PL, Cardesa A, Alós L, Pinto J, Traserra J. Sinonasal teratocarcinosarcoma: an unusual neoplasm. Pathol Res Pract. 1995;191(2):166-71.

Su YY, Friedman M, Huang CC, Wilson M, Lin HC. Sinonasal teratocarcinosarcoma. Am J Otolaryngol. 2010;31(4):300-3.