Published: 2021-08-23

A rare combination of polyp, inverted papilloma and squamous cell carcinoma of sphenoid sinus

Nitish Baisakhiya, Anusha Shukla, Kartikey Pandey


Inverted papilloma (IP) is a tumor most commonly originates from lateral wall of nose and benign in nature. Sphenoid sinus is a rare site of origin and involvement. Malignant changes are the rare possibility in the IP. In this case report we reported a rare case of squamous cell carcinoma in back ground of inverted papilloma of sphenoid sinus.


Sphenoid sinus, Inverted papilloma, Squamous cell carcinoma

Full Text:



Beaujeux R, Dietemann J, Brun F, Bourjat P. CT scan and MRI of sphenoid tumors and pseudo-tumors. Radiol Leaflets. 1994;34(3):214-29.

Morris L, Govindaraj S, Genden EM. Primary sphenoid sinus esthesioneuroblastoma. Am J Otolaryngol. 2004;25(5):350-3.

Clarke SR, Amedee RG. Schneiderian papilloma. J La State Med Soc. 1997;149(9):310-5.

Caparroz FA, Gregório LL, Kosugi EM. Evolution of endoscopic surgery in the treatment of inverted papilloma. Braz J Otorhinolaryngol. 2013;79(1):13-7.

Banhiran W, Casiano RR. Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm. Curr Opin Otolaryngol Head Neck Surg. 2005;13(1):50-4.

Mirza S, Bradley PJ, Acharya A, Stacey M, Jones NS. Sinonasal inverted papillomas: recurrence, and synchronous and metachronous malignancy. J Laryngol Otol. 2007;121(9):857-64.

Kim WS, Hyun DW, Kim CH, Yoon JH. Treatment outcomes of sinonasal inverted papillomas according to surgical approaches. Acta Otolaryngol. 2010;130(4):493-7.

Sun P, Chen XP, Pei F, Ma RX, Zhang Y, Chen Q, et al. Relationship between nasal inverted papilloma and human papillomavirus subtypes. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;45(4):310-3.

Lichius O, Kreppel MP, Stuetzer H, Semrau R, Eckel HE, Mueller RP. Single modality and multimodality treatment of nasal and paranasal sinuses cancer: a single institution experience of 229 patients. Eur J Surg Oncol. 2007;33(2):222-8.

Guillemaud JP, Witterick IJ. Inverted papilloma of the sphenoid sinus: clinical presentation, management, and systematic review of the literature. Laryngoscope. 2009;119(12):2466-71.

Lam PK, Smith N, Li JH, Fan YW, Yuen AP. Myxofibrosarcoma of the sphenoid sinus. J Laryngol Otol. 2002;116(6):464-6.