Nasopharyngeal mucoepidermoid carcinoma: a case report and review of its current management
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20214237Keywords:
Nasopharynx, Mucoepidermoid carcinoma, NasopharyngectomyAbstract
Salivary gland tumours arising at the nasopharynx is highly infrequent. Among them the commonest is mucoepidermoid carcinoma (MEC). Reports with a larger number of patients are often from Asian countries where nasopharyngeal squamous cell carcinoma is also predominant. Although nasopharyngeal MEC (NMEC) is a disease of adults, sporadic cases amongst children have been reported. We report a case of a 32 years old man presented with complaining of intermittent epistaxis over a year. His nasal endoscopy showed friable polypoid tumour at the right choanae. Histopathology revealed a NMEC and he underwent endoscopic endonasal nasopharyngectomy with adjuvant radiotherapy. The optimal treatment for NMEC is arbitrary due to the lack of evidence. However, unlike most sinonasal malignancies, NMEC has the tendency to manifest itself early and has good response to the treatment. Therefore, in this article we describe the clinical features and justifications for the selection of treatment options including surgical and non-surgical therapies and including the role of neck dissection.
References
Stewart FW, Foote FW, Becker WF. Muco-epidermoid tumors of salivary glands. Ann Surg. 1945;122(5):820-44.
Kusafuka K, Takizawa Y, Iida Y, Ebihara M, Onitsuka T, Kameya T. Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature. Virchows Arch. 2007;450(3):343-8.
Zhang XM, Cao JZ, Luo JW, Xu GZ, Gao L, Liu SY, et al. Nasopharyngeal mucoepidermoid carcinoma: a review of 13 cases. Oral Oncol. 2010;46(8):618-21.
Hemalatha AL, Kumar HKS. Nasopharyngeal mucoepidermoid carcinoma - a common entity at an uncommon location. J Clin Diagn Res. 2014;8(1):164-5.
Schramm VL, Imola MJ. Management of nasopharyngeal salivary gland malignancy. Laryngoscope. 2001;111(9):1533-44.
Ollero JM, Morón AH, Luis AM, Sánchez SM, Nazarewsky AA, López MJ, et al. Nasopharyngeal mucoepidermoid carcinoma: a case report and review of literature. Rep Pract Oncol Radiother. 2012;18(2):117-20.
Rosenbluth BD, Chou WW, Lee NY. IMRT for carcinomas of the nasopharynx. In: Bortfeld T, Schmidt-Ullrich R, DeNeve W, Wazer DE, eds. Image-guided IMRT. Berlin, Heidelberg: Springer; 2006.
Saade RE, Bell D, Garcia J, Roberts D, Weber R. Role of CRTC1/MAML2 translocation in the prognosis and clinical outcomes of mucoepidermoid carcinoma. JAMA Otolaryngol Head Neck Surg. 2016;142(3):234-40.
Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010;34(8):1106-21.
Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo I, et al. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer. 2006;45(5):470-81.