Plasmablastic lymphoma of nose and para-nasal sinuses in an immunocompetent patient


  • Arunabha Chakravati Department of Otorhinolaryngology, Lady Hardinge Medical College, New Delhi, India
  • Moazzam Mojahid Department of Otorhinolaryngology, Lady Hardinge Medical College, New Delhi, India
  • Rohini R. Nair Department of Otorhinolaryngology, Lady Hardinge Medical College, New Delhi, India
  • Shilpi Agarwal Department of Pathology, Lady Hardinge Medical College, New Delhi, India



Plasmablastic lymphoma, Sino-nasal, Neoplasm, Immuno-competent, Chemotherapy, Radiotherapy


Plasmablastic lymphoma (PbL) is a rare and aggressive neoplasm with heterogeneous clinical, histological and genetic features. It has been reported in both immuno-compromised and immuno-competent patients and commonly presents in the extra-nodal regions, but it is more heterogeneous in immuno-competent patients. Its clinical course is aggressive with early dissemination and poor response to therapy. A 61 year old male presented with left sided nasal bleeding and nasal obstruction for last 6 months, snoring and disturbed sleep for last 2 months. On examination, there was fullness over left side of nose and obliteration of left naso-facial groove. A mass lesion was seen in the left nasal cavity on endoscopy. There was bulge in the soft palate and the mass extended into the oropharynx. CECT showed a locally aggressive sino-nasal mass. Histopathology and immuno-histo-chemistry (IHC) of the biopsy were suggestive of plasmablastic lymphoma. A debulking surgery was done to relieve his obstructive symptoms. The patient received 3 cycles of EPOCH chemotherapy and radiotherapy to local site. At 9 months of follow up he presented with recurrence of the mass. Plasmablastic lymphoma presents in patients other than those with HIV. Awareness about its unique characteristics is crucial for establishing a correct diagnosis. Currently available treatments are ineffective in achieving long term remission and prognosis remains unfavourable with high incidence of recurrence

Author Biography

Arunabha Chakravati, Department of Otorhinolaryngology, Lady Hardinge Medical College, New Delhi, India

Department of Otorhinolaryngology, Director Professor


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