Published: 2021-03-24

A case of recurrent chondroblastic osteosarcoma mandible

Helena Babu, Rohit Sharma, Vinit K. Sharma, Tanu Aggarwal, Amit K. Rana


Osteosarcoma is an uncommon primary malignant tumor of bone. Craniofacial osteosarcomas constitute only about 6.5–7% of all osteosarcomas. The most common histopathologic type is chondroblastic type in head and neck group and osteoblastic in extremity group. We present a case report of 21 year old male patient with chondroblastic osteosarcoma with two episodes of recurrence. The tumour was dealt with left hemimandibulectomy followed by radiochemotherapy. After first recurrence he underwent right hemimandibulectomy. During second recurrence excision of growth followed by radiochemotherapy was done. Thus an aggressive multi-modality approach was adopted for treatment. Osteosarcoma is an uncommon primary malignant tumor of bone. Craniofacial Osteosarcomas are considered a separate category in view of their low histologic grade, less frequent metastases and better prognosis. The most common presentation is local swelling with or without pain. Aggressive surgical approach with post-surgical radiochemotherapy can be an effective tool.


Chondroblastic osteosarcoma, Osteosarcoma, Mandible, Hemimandibulectomy

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Chittaranjan B, Tejasvi MA, Babu BB, Geetha P. Intramedullary osteosarcoma of the mandible: a clinicoradiologic perspective. J Clin Imaging Sci. 2014;4(2):6.

Venkatesh K, Priyanka T, Rukmini NS, Bisanna J. Chondroblastic Variant of Osteosarcoma of Mandible: Report of a Rare Case. J Clin Diagn Res. 2016;10(8):12-4.

Seng D, Wu J, Fang Q, Liu F. Prognosis of osteosarcomas in the mandible: 15-year experience of 55 patients. Medicine (Baltimore). 2019;98(1):13875.

Vanden Bussche CJ, Sathiyamoorthy S, Wakely PE, Jr, Ali SZ. Chondroblastic osteosarcoma: cytomorphologic characeteristics and differential diagnosis on FNA. Cancer Cytopathol. 2016;124(7):493-500.

Picci P. Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis. 2007;2:6.

August M, Magenni SP, Dewitt D. Osteogenic sarcoma of the jaws: Factors influencing prognosis. Int J Oral Maxillofac Surg. 1997;26(3):198-204.

Mardinger O, Givol N, Talmi Y.P, Taicher S, Saba K. Osteosarcoma of the jaw. Oral Med Oral Pathol Oral Radiol Endod. 2001;91:445-51.

Agrawal RR, Bhavthankar JD, Mandale MS, Patil PP. Osteosarcoma of Jaw with Varying Histomorphologic Patterns: Case Report. J Orthop Case Rep. 2017;7(1):61-4.

Nthumba PM. Osteosarcoma of the jaws: a review of literature and a case report on synchronous multicentric osteosarcomas. World J Surg Oncol. 2012;10:240.