Multiple amyloid lesions in the lateral pharyngeal wall: a case report

Authors

  • Andres Claros Department of Otolaryngology, Clarós Clinic, Barcelona, Spain
  • Cristina Blebea Department of Otorhinolaryngology, ENT Scholarship, Clarós Clinic, Barcelona, Spain
  • Pedro Clarós Department of Otolaryngology, Clarós Clinic, Barcelona, Spain

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20211585

Keywords:

Amyloidosis, Pharynx, Larynx, Upper aerodigestive tract

Abstract

Amyloidosis represents a diverse group of disorders that have in common the deposition of amyloid protein in various extracellular tissues. Its clinical presentation may be systemic or localised. However, regions in the head and neck are rarely affected. This report discusses the case of a 57 year old man with a history of 6 years of left ear non-pulsatile tinnitus, who at the physical examination presented a polilobulated, yellowish oropharyngeal lesion, behind the left posterior pillar of the tonsil. Biopsy of the lesion sustained the diagnostic of light chain amyloidosis and subsequent evaluation was significant for establishing the diagnosis of localised amyloidosis. While further investigations a second laryngeal lesion was encountered. We present a case report of double synchronous amyloidosis localization on head and neck and asymptomatic lesions and discuss the implications for diagnosis and treatment.

References

Chiti F, Dobson CM. Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem. 2006;75:333-66.

Chuang E, Hori AM, Hesketh CD, Shorter J. Amyloid assembly and disassembly. J Cell Sci. 2018;131(8):86-90.

Pietruszewska W, Wągrowska-Danilewicz M, Klatka J. Amyloidosis of the head and neck: a clinicopathological study of cases with long-term follow-up. Arch Med Sci. 2014;10(4):846-52.

Westermark P, Benson MD, Buxbaum JN, Cohen AS, Frangione B, Ikeda S, et al. A primer of amyloid nomenclature. Amyloid. 2007;14(3):179-83.

Desport E, Bridoux F, Sirac C, Delbas S, Bender S, Fernandez B, et al. AL amyloidosis. Orphanet J Rare Dis. 2012;7(1):54.

Sataloff RT, Abaza M, Abaza NA, Markiwickz A, Hawkshaw M. Amyloidosis of the larynx. Ear Nose Throat J. 2001;80(6):369-70.

Passerotti GH, Caniello M, Hachiya A, Santoro PP, Imamura R, Tsuji DH. Multiple-sited amyloidosis in the upper aerodigestive tract: case report and literature review. Braz J Otorhinolaryngol. 2008;74(3):462-6.

Gilad R, Milillo P, Som PM. Severe Diffuse Systemic Amyloidosis with Involvement of the Pharynx, Larynx, and Trachea: CT and MR Findings. Am J Neuroradiol. 2007;28(8):1557-8.

Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, et al. Amyloidosis of the upper aerodigestive tract. Laryngoscope. 2003;113(12):2095-101.

Downloads

Published

2021-04-23

Issue

Section

Case Reports