The impact of occurrence of tinnitus in first degree relatives on the severity of disease among subjects

Authors

  • Mosanya T. J. Department of Psychiatry, LAUTECH Teaching Hospital, Osogbo, Osun Statte, Nigeria
  • Yusuf T. Department of Otorhinolaryngology, University College Hospital, Ibadan, Oyo State, Nigeria
  • Daniel A. Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Oyo State, Nigeria
  • Ogundoyin O. A. Department of Otorhinolaryngology, University College Hospital, Ibadan, Oyo State, Nigeria
  • Onakoya P. A. Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Oyo State, Nigeria
  • Adeosun A. A. Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Oyo State, Nigeria
  • AbdulWasiu-Idowu K. G. Department of Family Medicine, LAUTECH Teaching Hospital, Osogbo, Osun Statte, Nigeria
  • Yusuf B. O. Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Oyo State, Nigeria
  • Adeolu J. O. Institute of Child Health, University College Hospital, Ibadan, Oyo State, Nigeria
  • Adedeji W. A. Department of Clinical Pharmacology and Therapeutics, University College Hospital, Ibadan, Oyo State, Nigeria
  • Musa I. Department of Otorhinolaryngology, 6Institute of Child Health, University College Hospital, Ibadan, Oyo State, Nigeria
  • Ijitola J. O. Department of Otorhinolaryngology, 6Institute of Child Health, University College Hospital, Ibadan, Oyo State, Nigeria
  • Lasisi T. J. Department of Physiology/Oral Pathology, College of Medicine, University of Ibadan, Oyo State, Nigeria
  • Akeem O. Lasisi Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Oyo State, Nigeria

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20210154

Keywords:

Correlation, First degree relatives, Tinnitus

Abstract

Background: The aetiology of tinnitus and the factors that contribute to the exacerbation from mild to severe tinnitus are poorly known. Particularly, a role of genetics has been proposed for tinnitus, although this has not been conclusive. In order to establish a possible role for heritability in our population, we explored the history of tinnitus among first degree family members of those suffering from tinnitus using cross-sectional community-based strategy.

Methods: There were 300 subjects with idiopathic tinnitus with mean (±SD) age of 51.88 (±15.11, range=19-80 years) comprising 169 males and 131 females.  

Results: Tinnitus was severe in 37.9% and bilateral in 65.1% while 26.6% reported having family members with history of tinnitus. TInnitus was significantly more severe (p<0.001) and more frequent (p<0.001); and the psychological distress related to tinnitus (p<0.001) measured by the mini-TQ was worse among those with family history compared to those without. Bivariate analysis reveals that the presence of tinnitus in other family members, occurrence of tinnitus for more than 3 months (p=0.003), increasing age (0.001) and higher mean mini-TQ scores (0.001) showed significant association with severity of tinnitus. Logistic regression reveals that presence of tinnitus in other family members increases the odds of frequency of tinnitus by 5.08 (95% CI=1.70-15.12), elevates the mean scores of the mini-TQ by 1.31 (95% CI=1.20-1.44) while increasing age greater than 50 years increases the odds of severity of disease by 2.81 (95%CI=1.59-4.94).

Conclusions: We conclude that the findings of significant correlation between presence of tinnitus in first degree relatives and severity of tinnitus among the subjects provides an empirical evidence to explore a possible genetic aetiology for severe tinnitus in our population.

References

Erlandsson SI, Holgers KM. The impact of perceived tinnitus severity on health-related quality of life with aspects of gender. Noise Health. 2001;3:39-51,434-42.

McCombe A, Bagueley D, Coles R, McKenna L, McKinney C,. Guidelines for the grading of tinnitus severity: the results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999. Clin Otolaryngol. 2001;26:388-93.

Martines F, Bentivegna D, Martines E, Sciacca V, Martinciglio G. Assessing audiological, pathophysiological and psychological variables in tinnitus patients with or without hearing loss. Eur Arch Oto-Rhino-Laryngol. 2010;267:1685-93.

Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. Am J Med. 2010;123:711-8.

Davis A, El Refaie A. Epidemiology of tinnitus. In: Tyler RS, ed. Tinnitus Handbook. San Diego: Singular; 2000:1-21.

Gopinath B, McMahon CM, Rochtchina E, Krapa MJ, Mitchell P. Incidence, persistence, and progression of tinnitus symptoms in older adults: The Blue Mountains Hearing Study. Ear Hear. 2010;31:407-12.

Lasisi AO, Gureje O. Prevalence of insomnia and impact on quality of life among community elderly with tinnitus. Ann Otorhinolaryngol. 2011;120:226-30.

Lasisi OA, Abiona TA Gureje O. Tinnitus in the elderly: Profile, correlates, and impact in the Nigerian Study of Ageing. Otolaryngol Head Neck Surg. 2010;143(4): 510-5.

Amanat S, Gallego-Martinez A, Lopez-Escamez JA. Genetic inheritance and its contribution to tinnitus. In: Current Topics in Behavioral Neurosciences. Springer, Berlin: Heidelberg; 2020.

Gottschalk MG, Domschke K. Novel developments in genetic and epigenetic mechanisms of anxiety. Curr Opin Psychiatr. 2016;29(1):32-8.

Hiller W, Goebel G. Rapid assessment of tinnitus-related psychological distress using the Mini-TQ; Int J Audiol. 2004;43:600-4.

Goebel G, Hiller W. Quality management in the therapy of chronic tinnitus. In: Hazell J, ed. Proceedings of the sixth International Tinnitus Seminar, Cambridge. Tinnitus and Hyperacusis Center, London; 1999:357-363.

Scott B, Lindberg P. Psychological profile and somatic complaints between help-seeking and non-help-seeking tinnitus subjects. Psychosomatics. 2000;41:347-52.

Cederroth CR, Kähler AK, Sullivan PF and Lopez-Escamez JA. Genetics of Tinnitus: Time to Biobank Phantom Sounds. Front Genet. 2017;8:110.

Maas IL, Brüggemann P, Requena T, Bulla J, Edvall NK, vB Hjelmborg J, et al. Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. Genet Med. 2017;19(9):1007-12.

Lopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, et al. Genetics of tinnitus: an emerging area for molecular diagnosis and drug development. Front Neurosci. 2016;10(377):377.

Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlstrom E, et al. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet. 2006;9:875-82.

Pedersen N L, Lichtenstein P, Svedberg P. The Swedish Twin Registry in the third millennium. Twin Res. 2002;5:427-32.

Van Dongen J, Slagboom PE, Draisma HH, Martin NG, Boomsma DI. The continuing value of twin studies in the omics era. Nat Rev Genet. 2012;13:640-53.

Bogo R, Farah A, Karlsson KK, Pedersen NL, Svartengren M, Skjonsberg A. Prevalence, incidence proportion, and heritability for tinnitus: a longitudinal twin study. Ear Hear. 2016;38:292-300.

Requena T, Cabrera S, Martin-Sierra C, Price SD, Lysakowski A, Lopez-Escamez JA. Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere’s disease. Hum Mol Genet. 2015;24:1119-26.

Martin-Sierra C, Gallego-Martinez A, Requena T, Frejo L, BatuecasCaletrio A, Lopez-Escamez JA. Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere’s disease. Eur J Hum Genet. 2017;25:200-7.

Muller K, Edvall NK, Idrizbegovic E, Huhn R, Cima R, Persson V, et al. Validation of online versions of tinnitus questionnaires translated into Swedish. Front Aging Neurosci. 2016;8:272.

Schlee W, Hall D, Edvall NK, Langguth B, Canlon B, Cederroth CR. Visualization of global disease burden for the optimization of patient management and treatment. Front Med. 2017;4:86.

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Published

2021-01-25

Issue

Vol. 7 No. 2 (2021): February 2021

Section

Original Research Articles