Published: 2020-12-24

A rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses

Jasmine Ratti, Vishav Yadav, Sanjeev Bhagat, Dinesh K. Sharma


Sino nasal malignancies account for only 0.2-0.8% of all malignancies and undifferentiated carcinoma is rare malignant tumour of sinonasal tract, with extremely poor prognosis. We report a case of sinonasal undifferentiated carcinoma which we managed by surgery followed by post-operative radiotherapy with concomitant platinum-based chemotherapy. Although the overall survival is about 20% at 5 years and there are frequent recurrences combined modality treatment is the best management option available at present.


Sinonasal undifferentiated carcinoma, Maxillectomy, Blue small round cell tumors

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Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and paranasal sinus carcinoma: are we making progress? Cancer. 2001;92:3012-29.

Rice DH, Stanley RB. Surgical therapy of tumors of the nasal cavity, ethmoid sinus, and maxillary sinus. In: Panje W (ed). Comprehensive management of head and neck tumors. 2nd ed. Philadelphia: Saunders. 1999;558-81.

Goldenberg D, Golz A, Fradis M, Netzer A, Joachims HZ. Malignant tumors of the nose and paranasal sinuses: az retrospective review of 291 cases. Ear Nose Throat J. 2001;80:272-7.

Frierson HF, Mills SE, Fechner RE, Taxy JB, Levine PA. Sinonasal undifferentiated carcinoma. Am J Surg Pathol. 1986;10:771-9.

Su SY, Bell D, Hanna EY. Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. Int Arch Otorhinolaryngol. 2014;18:S149-56.

Smith SR, Som P, Fahmy A, Lawson W, Sacks S, Brandwein M. A Clinicopathological Study of Sinonasal Neuroendocrine Carcinoma and Sinonasal Undifferentiated. Carcinoma Laryngoscope. 2000;110:1617-22.

Yoshida E, Aouad R, Fragoso R, Farwell DG, Gandour-Edwards R, Donald PJ et al. Improved clinical outcomes with multimodality therapy for sinonasal undifferentiated carcinoma of the head and neck. Am J Otolaryngol. 2013;34(6):658-63.

Reiersen DA, Pahilan ME, Devaiah AK. Meta-analysis of treatment outcomes for sinonasal undifferentiated carcino- ma. Otolaryngol Head Neck Surg, 2012;147:7-14.

Kim BS, Vongtama R, Juillard G. Sinonasal undifferentiated carcinoma: case series and literature review. Am J Otolaryngol. 2004;25:162-6.

National Institute for Health and Care Excellence. Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and over. London: NICE; 2016. Available from: https://www.nice. Accessed on 10/10/2020.

Lund VJ, Clarke PM, Swift AC. Nose and paranasal sinus tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):S111-8.

Christopherson K, Werning JW, Malyapa RS. Radiotherapy for sinonasal undifferentiated carcinoma. Am J Otolaryngol. 2014;35(2):141-6.