A rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20205645Keywords:
Sinonasal undifferentiated carcinoma, Maxillectomy, Blue small round cell tumorsAbstract
Sino nasal malignancies account for only 0.2-0.8% of all malignancies and undifferentiated carcinoma is rare malignant tumour of sinonasal tract, with extremely poor prognosis. We report a case of sinonasal undifferentiated carcinoma which we managed by surgery followed by post-operative radiotherapy with concomitant platinum-based chemotherapy. Although the overall survival is about 20% at 5 years and there are frequent recurrences combined modality treatment is the best management option available at present.
References
Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and paranasal sinus carcinoma: are we making progress? Cancer. 2001;92:3012-29.
Rice DH, Stanley RB. Surgical therapy of tumors of the nasal cavity, ethmoid sinus, and maxillary sinus. In: Panje W (ed). Comprehensive management of head and neck tumors. 2nd ed. Philadelphia: Saunders. 1999;558-81.
Goldenberg D, Golz A, Fradis M, Netzer A, Joachims HZ. Malignant tumors of the nose and paranasal sinuses: az retrospective review of 291 cases. Ear Nose Throat J. 2001;80:272-7.
Frierson HF, Mills SE, Fechner RE, Taxy JB, Levine PA. Sinonasal undifferentiated carcinoma. Am J Surg Pathol. 1986;10:771-9.
Su SY, Bell D, Hanna EY. Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. Int Arch Otorhinolaryngol. 2014;18:S149-56.
Smith SR, Som P, Fahmy A, Lawson W, Sacks S, Brandwein M. A Clinicopathological Study of Sinonasal Neuroendocrine Carcinoma and Sinonasal Undifferentiated. Carcinoma Laryngoscope. 2000;110:1617-22.
Yoshida E, Aouad R, Fragoso R, Farwell DG, Gandour-Edwards R, Donald PJ et al. Improved clinical outcomes with multimodality therapy for sinonasal undifferentiated carcinoma of the head and neck. Am J Otolaryngol. 2013;34(6):658-63.
Reiersen DA, Pahilan ME, Devaiah AK. Meta-analysis of treatment outcomes for sinonasal undifferentiated carcino- ma. Otolaryngol Head Neck Surg, 2012;147:7-14.
Kim BS, Vongtama R, Juillard G. Sinonasal undifferentiated carcinoma: case series and literature review. Am J Otolaryngol. 2004;25:162-6.
National Institute for Health and Care Excellence. Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and over. London: NICE; 2016. Available from: https://www.nice. org.uk/Guidance/NG36/evidence. Accessed on 10/10/2020.
Lund VJ, Clarke PM, Swift AC. Nose and paranasal sinus tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):S111-8.
Christopherson K, Werning JW, Malyapa RS. Radiotherapy for sinonasal undifferentiated carcinoma. Am J Otolaryngol. 2014;35(2):141-6.
