Comparison of neo-pharmatherapy and volume building therapy in USSL
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20205622Keywords:
DS, Neopharma, PTA, SRT, Unilateral sudden sensorineural lossAbstract
Background: Objective of the study was to identify healthy individuals with idiopathic unilateral sudden hearing loss (USSL) and treating them under either of two different therapeutic protocols to judge the hearing recovery.
Methods: Prospective crossover series study of 72 adult patients (males and females) of Indian origin was performed. Diagnosis of USSL and treating under two different protocols as; Group "A" was treated with oral combination form of Vinpocetine, Q-enzyme, Piracetam and B. Serrata over 3 months; while Group "B" was treated with Plasma expander IV Dextran, IV Dexamethasone, I/M Cyanocobalamine and Cyclandelate for 5 days followed by oral Dexametasone for 5 days Methycobalamine over 3 months. Common audiological and communicative parameters were applied in both treated groups to assess and analyse the responses incurred at the end of treatment. The graded system was applied to evaluate the SRT. Better outcomes based on the trialed drugs and their action is assessed.
Results: 61 of 72 patients successfully completed the regimes. After applying Siegel's grading for judging the SRT gains; group A had 16, 10 and 5 with grade I, II, III recovery while group B had 8, 6, 16 with grades I, II, III recovery respectively. It was noticed that group A patients showed earlier recovery of higher frequencies.
Conclusions: Both subject groups showed improved BC gains at end treatment. There was marked hearing recovery (Gr. I, II-Siegel's classification) in group "A" was (78%) which is significant over group "B" (50%) and above natural recovery rate.
References
Judith ECL. Speech-language and educational consequences of unilateral hearing loss in children. Arch Otolaryngol Head Neck Surg. 2004;130(5):524-30.
Sara S. Bilateral sudden sensorineural hearing loss: review. JLO. 2014;128(1):8-15.
Jion C Al 2017 doi.org/10.1371 journal.
Ginkgo biloba. Available at https://go.drugbank.com/drugs/DB01381. Accessed on 12 June 2020.
Piracetam. Available at www.drugbank.ca- Piracetam. Accessed on 10 July 2020.
Gouliaev AH, Senning A. Piracetam and other structurally related nootropics. Brain Research. 1994;19(2):180-222.
Siddiqui MZ, Serrata B. A potential antiinflammatory agent: an overview. Indian J Pharma Sci. 1011;73(30): 255-61.
Co-enzyme Q-10. Available at www.natural medicine comprehensive database.com/ Co-enzyme Q-10/ Accessed on 20 April 2020.
Jarvis SJ, Giangrande V, John G, Thornton ARD. Management of acute idiopathic sensorineural hearing loss: a survey of UK ENT Consultants. Acta Otorhinolaryngol Ital. 2011;31(2):85-9.
Leung MA, Flaherty A, Zhang JA. Sudden sensorineural hearing loss: primary care update. Hawaii J Med Public Health. 2016;75(6):172-4.
Cyclandelate. Available at https:// www. drugbank. ca/ drugs- cyclandelate/DB04838. Accessed on 10 July 2020.
Sudden hearing loss. Available at: https://www.attune.com.au/2020/02/14/how-to-deal-with-sudden-sensorineural-hearing-loss/. Accessed on 12 July 2020.
Vitamin B-12. Available at https:// www. drugbank. ca/drugs/DB00115. Accessed on 12 July 2020.
Kim SY, Kim HJ. Severe hearing impairment and risk of depression: A national cohort study. PLoS ONE. 2017;12(6): e0179973.
Nageris BI, Attias UDJ. Magnesium Treatment for sudden hearing loss. Ann Otol Rhinol Laryngol. 2004;113(8):672-5.
Conlin AE, Parnes LS. Treatment of sudden sensorineural hearing loss: a systematic review. Arch OLHNS. 2007;133(6):573-81.
Kim YG, Jung YG, Eun Y. Effect of steroid, carbogen inhalation and lipoprostagandin E1 combination therapy for sudden sensorineural hearing loss. Am J Otolaryngol. 2011;32(2):91-5.
Steriods for idiopathic sudden sensorineural hearing loss. Cochrane Database Sys Rev. 2006;22(1):18-23.
Silverstein H, Issacson JE, Olds MJ. Dexamethasone inner ear perfusion for treatment of Meniere's disease: a prospective, randomized, double blind, crossover trial. Am J Otol. 1998;19(2):196-201.
Chou YE, Chen PR, Kuo IJ. Comparison of intermittent intratympanic steroid injection and near continual transtympanic perfusion as salvage treatment for sudden sensorineural hearing loss. Laryngoscope. 2013;123:2264-9.
Sudden sensorineural hearing loss. Available at https://www.researchgate.net/profile/Guilherme-Machado-De-Carvalho/publication/312155104_Up-toate_in_Auditory_Neuropathy_Spectrum_Disorder_Clinical_Diagnostic_and_Therapeutic_Features/links/5872b7d508aebf17d3af5a0a/Up-to-Date-in-Auditory-Neuropathy-Spectrum-Disorder-Clinical-Diagnostic-and-Therapeutic-Features.pdf. Accessed on 12 July 2020.
Sousa MB, Cazemier S, Stegman I, Thomer H. Use of vasodialtors in idiopathic sudden sensorineural hearing loss: a systemic review. J Int Adv Otol. 2017;13(3):399-403.
Walter WG, Cooper R, Aldridge VJ, McCullum WC, Winter AL. Contigent negative variation. 2013;203:380-4.
Nice guidelines on sudden sensorineural hearing loss. Available at https:// www. nice. org.uk/guidance/ng98. Accessed on 12 July 2020.
