Fluorodeoxyglucose positron emission tomography-computed tomography base response assessment in primary thyroid lymphoma

Tarun Kumar Jain, Anushree Punia, Shikha Dhal, Guman Singh, Hemant Malhotra, Ankur Punia, Naveen Gupta


Isolated primary thyroid lymphoma and lesion in the thyroid gland presenting as a lymphoma, both are uncommon entities. This subgroup of thyroid malignancies is managed in different ways as compared to common thyroid malignancies. A 63-year-old male diagnosed as non-Hodgkin’s lymphoma of the thyroid gland underwent for F-18 fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT). It revealed isolated FDG avid soft tissue mass in left lobe of thyroid gland. After two and six cycles of chemotherapy, PET-CT was perfomed and response assessed in Deauville scores.  


Primary thyroid lymphoma, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Deauville score

Full Text:



Sangalli G, Serio G, Zampatti C, Lomuscio G, Colombo L. Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases. Cytopathology. 2001;12:257-63.

Thieblemont C, Mayer A, Dumontet C, Barbier Y, Callet-Bauchu E, Felman P, et al. Primary thyroid lymphoma is a heterogeneous disease. J Clinic Endocrinol Metabol. 2002;87(1):105-11.

Adhikari LJ, Reynolds JP, Wakely PE Jr. Multi-institutional study of fine-needle aspiration for thyroid lymphoma. J Am Soc Cytopathol. 2016;5:170-6.

Schoder H, Moskowitz C. PET imaging for response assessment in lymphoma: Potential and limitations [viii.] Radiol Clin North Am. 2008;46:225-41.

Naswa N, Sharma P, Nazar AH, Mohapatra TK, Bal C, Kumar R. (18) F-FDG PET/CT for initial assessment and response monitoring in a case of high grade primary lymphoma of the thyroid gland: A case report and review of literature. Indian J Nucl Med. 2014;29:94-6.

Nakadate M, Yoshida K, Ishii A, Koizumi M, Tochigi N, Suzuki Y, et al. Is 18F-FDG PET/CT useful for distinguishing between primary thyroid lymphoma and chronic thyroiditis? Clin Nucl Med. 2013;38:709-14.

Basu S, Li G, Bural G, Alavi A. Fluorodeoxyglucose positron emission tomography (FDG-PET) and PET/computed tomography imaging characteristics of thyroid lymphoma and their potential clinical utility. Acta Radiol. 2009;50:201-4.

Mikosch P, Wurtz FG, Gallowitsch HJ, Kresnik E, Lind P. F-18-FDG-PET in a patient with Hashimoto's thyroiditis and MALT lymphoma recurrence of the thyroid. Wien Med Wochenschr. 2003;153:89-92.

Marchesi M, Biffoni M, Biancari F. False-positive finding on 18 F-FDG PET after chemotherapy for primary diffuse large B-cell lymphoma of the thyroid: A case report. Jpn J Clin Oncol. 2004; 34:280-1.

Chander S, Zingas AP, Bloom DA, Zak IT, Joyrich RN, Getzen TM. Positron emission tomography in primary thyroid lymphoma. Clin Nucl Med. 2004;29:572-3.

Lin EC. FDG PET/CT for assessing therapy response in primary thyroid lymphoma. Clin Nucl Med. 2007;32:152-3.

Peixoto R, Correia Pinto J, Soares V, Koch P, Taveira Gomes A. Primary thyroid lymphoma: A case report and review of the literature. Ann Med Surg (Lond). 2016;13:29-33.

Barrington SF, Kluge R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Eur J Nucl Med Mol Imaging. 2017;44(1):97-110.