Clinical study to compare the effect of intratympanic injection of lidocaine and dexamethasone in tinnitus of cochlear origin

Authors

  • Surabhiraj . Department of Otorhinolaryngology, Mysore Medical College, Mysore, Karnataka http://orcid.org/0000-0002-9709-3973
  • Somanath B. Megalamani Department of Otorhinolaryngology, Mysore Medical College, Mysore, Karnataka
  • Raveendra P. Gadag Department of Otorhinolaryngology, Mysore Medical College, Mysore, Karnataka

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20204461

Keywords:

Tinnitus, Lidocaine, Dexamethasone

Abstract

Background: Due to various aetiologies and the less known mechanism involved in tinnitus no treatment modality gives consistent results. Here, we are comparing the efficacy of intratympanic injections of lidocaine and dexamethasone.  

Methods: Out of 100 selected patients, consecutive patients who fulfilled the inclusion and exclusion criteria are randomly allocated into one of the 2 study groups (50 members each). Intratympanic injection of lidocaine and dexamethasone are given to respective group weekly for 3 consecutive weeks and response is assessed at 1 month and 2nd month of injection.  

Results: In our study, maximum patients were in the age group of 56-65 yrs. When the effect of lidocaine and dexamethasone on tinnitus (based on THI-tinnitus handicap inventory questionnaire) is compared, dexamethasone is found to be more efficacious than lidocaine with a p value<0.005. Out of total, 96% of dexamethasone group and 68% of lignocaine group have got improved THI score during second follow up. While assessing the effect of lidocaine and dexamethasone on pure tone audiogram (PTA) it is found that, dexamethasone is showing more improvement when compared to lignocaine (p value<0.05). Regarding the adverse effects of injection, side effect is more with lidocaine (50%) than that of dexamethasone (36%), most common adverse effect which we came across was burning type of pain, followed by giddiness which last only for few seconds.  

Conclusions: Dexamethasone is effective in reducing the overall THI score hence reduces handicap when compared with that of lidocaine with added advantage on hearing.

Author Biography

Surabhiraj ., Department of Otorhinolaryngology, Mysore Medical College, Mysore, Karnataka

Department of Otorhinolaryngology, 

M S ENT

References

Hazell J. Incidence, classification, and models of tinnitus. Diseas Ear. 1998:185-95.

Leske MC. Prevalence estimates of communicative disorders in the US Language, hearing and vestibular disorders. Asha. 1981;23:229-37.

Sarton, G, Siegel, F. (1936). Forty-Sixth Critical Bibliography of the History and Philosophy of Science and of the History of Civilization (To End of February 1936, With Special Reference to China and Japan). Isis. 25(2):522-613.

Risey JA, Guth PS, Amedee RG. Furosemide distinguishes central and peripheral tinnitus. Int Tinnitus J. 1995;1(2):99-103

Denk DM, Heinzl H, Franz P, Ehrenberger K. Caroverine in tinnitus treatment: a placebo-controlled blind study. Acta Oto-laryngologica. 1997;117(6):825-30.

Cesarani A, Capobianco S, SOi D, Giuliano DA, Alpini D. Intratympanic dexamethasone treatment for control of subjective idiopathic tinnitus: our clinical experience. Int Tinnit J. 2002;8(2):111-4.

Yılmaz I, Özlüoğlu L, Çağıcı CA, Akkuzu G, Özgirgin N, Yavuz H, et al. Effectiveness of intratympanic dexamethasone on tinnitus: A clinical experience. Türk otolarengoloji arşivi. 2006;44(2):81-7.

Coles Rr, C. Thompson Ad, 'Donoghue Gm. Intra‐tympanic injections in the treatment of tinnitus. Clinic Otolaryngol Alli Sci. 1992;17(3):240-2.

Sakata H, Kojima Y, Koyama S, Furuya N, Sakata E. Treatment of cochlear tinnitus with transtympanic infusion of 4% lidocaine into the tympanic cavity. Int Tinnit J. 2001;7(1):46-50.

Downloads

Published

2020-10-23

Issue

Section

Original Research Articles