Clinical study of carcinoma of larynx: a retrospective analysis
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20204640Keywords:
Laryngeal carcinoma, Epidemiology, Clinical presentation, ComplicationsAbstract
Background: Carcinoma of larynx is the third most common cancer in head and neck, sixth most common cancer among men in India. This study aims to identify the patterns of clinical presentation, epidemiological features and management of laryngeal carcinoma in a tertiary care centre of Indian armed forces.
Methods: This is a retrospective analysis of patients admitted in a Command hospital from January 2007 to December 2009.
Results: A total of 28 patients were treated in 3 year duration. All the patients were males. The majority of patients belonged to 7th decade of life with youngest 49 years old and the oldest 80 years. Supraglottic carcinoma (71%) was the most common laryngeal carcinoma followed by glottic carcinoma(29%).Hoarseness of voice (82%) was the most common presenting complaint followed by dysphagia (42%) and dysponea (21%). 32% of patients reported after initial emergency tracheostomy. 12 (42%) patients were treated with curative surgery, 4 (14%) were treated with curative radiotherapy. Rest of patients required palliative therapy.
Conclusions: Laryngeal carcinoma is found predominantly in males at seventh decade of life and advanced stage. Treatment with curative intent may be possible in around 70% of patients.
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References
Ferlay J, Soerjomataram I, Ervik M, Forman D, Bray F, Dikshit R, et al. Cancer incidence and mortality worldwide in 2012. lyon, france: international agency for research on cancer. Available at: https://publications.iarc.fr/Databases/Iarc-Cancerbases/GLOBOCAN-2012-Estimated-Cancer-Incidence-Mortality-And-Prevalence-Worldwide-In-2012-V1.0-2012. Accessed on 20 September 2020.
Individual registry-wise annexure, Three-year Report of Population Based Cancer Registries 2009-2011. Available at: https://main.icmr.nic.in/sites/default/ files/reports/Preliminary_Pages_Printed.pdf. Accessed on 20 September 2020.
Bobde S, Jain A, Balasubramanium G. Epidemiological review of laryngeal cancer: An Indian perspective. Indian J Med Paediatr Oncol. 2015;36(3):154-60.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin. 2017;67(1):31-50.
Glade MJ. Food, nutrition, and the prevention of cancer: a global perspective. American institute for cancer research/world cancer research fund, American institute for cancer research, 1997. Nutrition. 1999;15(6):523-6.
Tuyns AJ, Esteve J, Raymond L, Berrino F, Benhamou E, Blanchet F, et al. Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case/control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer. 1988;41:483-91.
Falk RT, Pickle LW, Brown LM. Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas. Cancer Res. 1989;49:4024.
Licitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G, et al. Cancer of the larynx. Crit Rev Oncol Hematol. 2003;47(1):65-80.
Austin DF. Larynx. In: Schottenfeld D, Fraumeni JF, eds. Cancer epidemiology and prevention. Philadelphia: WB Saunders; 1982:554-63.
Berrino F, Gatta G. Variation in survival of patients with head and neck cancer in Europe by the site of origin of the tumours. Eurocare working group. Eur J Cancer. 1998;34:2154-61.
Greene F. Larynx. In: Page D, Fleming I, eds. AJCC cancer staging handbook.6th ed. Chicago: Springer; 2002;61-5.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7-30.
Bresson K, Rasmussen H, Rasmussen PA. Pharyngocutaneous fistulae in totally laryngectomized patients. J Laryngol Otol. 1974;88: 835-42.
Qureshi SS, Chaturvedi P, Pai PS, Chaukar DA, Deshpande MS, Pathak KA, et al. A prospective study of pharyngocutaneous fistulas following total laryngectomy. J Can Res Ther. 2005;1:51-6.
Papazoglou G, Doundoulakis G, Terzakis G, Dokianakis G. Pharyngocutaneous fistula after total laryngectomy: Incidence, cause and treatment. Ann Otol Rhinol Laryngol. 1994;103:801-5.
Pesko P, Sabljak P, Bjelovic M, Stojakov D, Simic A, Nenadic B, et al. Surgical treatment and clinical course of patients with hypopharyngeal carcinoma. Dis Esophagus. 2006;19(4):248-53.
Herranz J, Sarandeses A, Fernández MF, Barro CV, Vidal JM, Gavilán J. Complications after total laryngectomy in nonradiated laryngeal and hypopharyngeal carcinomas.Otolaryngol Head Neck Surg. 2000;122(6):892-8.
Ganly I, Patel S, Matsuo J, Singh B, Kraus D, Boyle J, et al. Postoperative complications of salvage total laryngectomy.Cancer. 2005;103(10):2073-81.
Green F. Larynx. AJCC cancer staging handbook. 7th ed. Chicago: Springer; 2009:81-92.
