A comprehensive study on haematological and platelet related changes following septoplasty
Keywords:Septoplasty, Platelet count, Nasal obstruction symptom evaluation score
Background: Septoplasty is an elective surgical procedure indicated for the improvement of anatomic nasal airway obstruction. Platelets have an important role in endothelium damage repair and regulating hemostasis. Platelets produce pro-inflammatory mediators such as cytokines and chemokines during vascular inflammation. Aim of the study was to determine various types of changes that occur in Haematology and Platelet profile in patients after they undergo Septoplasty.
Methods: The study was conducted between January 2019 to June 2020 on 50 patients attending ENT OPD in Vinayaka Mission’s KirupanandhaVariyar Medical College and Hospital, Salem. 50 patients fulfilling inclusion/ exclusion criteria who give informed consent were included in the study.
Results: The parameters with no significant differences were found in red blood cells, white blood cells, platelet count, erythrocyte sedimentation rate, haemoglobin (Hb), hematocrit (Htc), mean corpuscular volume, mean corpuscular hemoglobin concentration (MCHC), and platelet distribution width values. mean platelet volume (MPV) value was decreased, platelet-to-lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) values were increased.
Conclusions: In our study, MPV value was decreased, PLR and NLR values were increased significantly after septoplasty. Also, the decrease in nasal obstruction symptom evaluation (NOSE) score after surgery is the confirmatory parameter proving that septoplasty not only improves the quality of life but also significantly corrects the altered blood and platelet related parameters in nasal septal deviation patients.
Rahman A, Hashmi SF, Hasan SA, Arif SH. Role of septoplasty in reducing the incidence of comorbidities associated with elevated levels of mean platelet volume. Egypt J Otolaryngol. 2016;32(3):156.
Al-Shehri AM, Amin HM, Necklawy A. Retrospective study of endoscopic nasal septoplasty. Biomedic Resear Ind. 2013;24(3):337-40.
Bhattacharyya N. Ambulatory sinus and nasal surgery in theUnited States: Demographics and perioperative outcomes. Laryngosco. 2010;120:635-8.
Both R, Mathur NN. Comparative evaluation of conventional versus endoscopic septoplasty for limited septal deviation and spur. J Laryngol Otol. 2009;123(7):737-41.
Drager LF, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: an emerging risk factor for atherosclerosis. Ches. 2011;140(2):534-42.
Geiser T, Buck F, Meyer BJ, Bassetti C, Haeberli A. Invivo platelet activation is increased during sleep in patients with obstructive sleep apnea syndrome. Respirat. 2002;69:229-34
Getz AE, Hwang PH: Endoscopic septoplasty. Curr Opin Otolaryngol Head Neck Surg. 2008;16(1):26-31.
Jain M, Chouhan AN, Harshwardhan R. Conventional Septoplasty versus Endoscopic Septoplasty: A Comparative Study. Peop J Scient Resear. 2011;4(2):24.
Song J, Sundar KM, Hoidal J, Prchal JT. Hematological Changes in Chronic Sustained Hypoxia and Chronic Intermittent Hypoxia in a Mouse Model.
Mao-Chang Su, Jung-Liang Chiang, Rong-San Jiang: Endoscopic Septoplasty in Conjunction with Endoscopic Sinus Surgery. Mid Taiwan J Med. 2004;9:38-4.
Maran AGD, Lund VJ: Trauma to nose and sinuses. In: 1st Edn.; Clinical Rhinology, New York: Thieme 1990;110-139.
Meng X, Wang W, Wei G, Chang Q, He F, Ming L. A high or a reasonably-reactively elevated platelet-to-lymphocyte ratio, which plays the role?. Platel. 2016;27(5):491.
Murray JA, Maran AG, Mackenzie IJ, Raab G. Open ν Closed Reduction of the Fractured Nose. Arch Otolaryngol. 1984;110(12):797-802.
Nawaiseh S, Al-Khartoum N. Endoscopic septoplasty: a retrospective analysis of 60 cases. J Pak Med Assoc. 2010;60(10):796-8.
Nayak DR, Balakrishnan R, Murty D, Hazarika P. Endoscopic septoturbinoplasty: our update series. Ind J Otolaryngol Head Neck Surg. 2002;54(1):20-4.
Nishi Gupta. Endoscopic Septoplasty. Ind J Otolaryngol Head Neck Surg. 2005;57(3):240-43.
Thejas SR, Mohan S. Effectiveness of isolated septal surgeries in nasal septal deviations: A prospective study with reference to the nasal obstruction symptom evaluation scale. Annals of Ind Acad Otorhinolaryngol Head Neck Surg. 2019;3(2):63-8.