Oropharyngeal adenocarcinoma as a rare presentaton secondary to gastric adenocarcinoma: a case study

Authors

  • Rajeev Kumar Jain Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Deepak Kumar Gupta Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Chultim Dolma Bhutia Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Ashvanee Kumar Chaudhary Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Vishwambhar Singh Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Mohit Mangla Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  • Lincoln Pujari Department of Radiation Oncology, Homi Bhabha cancer hospital and MPMMCC, Varanasi, Uttar Pradesh, India
  • Ipsita Dhal Department of Pathology, Homi Bhabha cancer hospital and MPMMCC, Varanasi, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20205082

Keywords:

Oropharynx, Adinocarcinoma, Gastric carcinoma, Radiotheray, Chemotherary, CDX-2

Abstract

Adenocarcinoma of oropharynx is a rarely encountered entity. It may be primary or secondary as metastasis from a distant site. Secondary adenocarcinoma of base of tongue is even more uncommon, few cases have been reported in the literature till date including one from stomach as a primary site. We are presenting a case of secondary adenocarcinoma of base of tongue metastasised from stomach after one and half years of successful treatment consisting of surgery and adjuvant chemotherapy.

Author Biographies

Rajeev Kumar Jain, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Professor and Head, Otorhinolaryngology

Deepak Kumar Gupta, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident, Otorhinolaryngology

Chultim Dolma Bhutia, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident, Otorhinolaryngology

Ashvanee Kumar Chaudhary, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Senior Resident,Otorhinolaryngology

Vishwambhar Singh, Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Associate Professor, Otorhinolaryngology

Mohit Mangla, Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Junior Resident, Dept. of General Surgery

Lincoln Pujari, Department of Radiation Oncology, Homi Bhabha cancer hospital and MPMMCC, Varanasi, Uttar Pradesh, India

Assistant Professor, Radiation Oncology

Ipsita Dhal, Department of Pathology, Homi Bhabha cancer hospital and MPMMCC, Varanasi, Uttar Pradesh, India

Assistant Professor, Pathology

References

Auluck A, Hislop G, Bajdik C, Poh C, Zhang L, Rosin M. Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV) related and HPV-unrelated sites in a multicultural population: the British Columbia experience. Cancer. 2010;116:2635-44.

Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Martin SP, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48:3282-7.

McCoy GD, Wynder EL. Etiological and preventive implications in alcohol carcinogenesis. Cancer Res. 1979;39:2844-50.

Brugere J, Guenel P, Leclerc A, Rodriguez J. Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth. Cancer. 1986;57 (2):391-5.

Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, et al. A review of human carcinogens-Part B: biological agents. Lancet Oncol. 2009;10(4):321-2.

Eskiizmir G, Özgür E, Tanyeri G, Ayhan S. Primary adenocarcinoma of the base of tongue: a rare case. J Med Updates. 2014;4(2):81-5.

Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg. 2005;241(1):27-39.

Acosta RD, Wong RK. Differential diagnosis of upper gastrointestinal bleeding proximal to the ligament of Trietz. Gastrointest Endosc Clin N Am. 2011;21(4):555-66.

Slova D, Paniz MA, Moisini I, Levi G, Urken M, Masoor S, et al. Colonic-type adenocarcinoma of the base of the tongue: a case report of a rare neoplasm. Head Neck Pathol. 2012;6(2):250-4.

Prakash SB, Leelatejaswini RM, Veenapani MK, Geetha C, Nishaan. A rare case report of synchronous malignancy – squamous cell carcinoma of base of tongue and adeno carcinoma of stomach. J Evol Med Dent Sci. 2014;3(59):13338-42.

Sharma N, Purkayastha A, Arora C, Sahai K. Colonic phenotype of adenocarcinoma base of the tongue: An entity rarely reported and treated with definitive chemoradiation. Int J Oral Health Sci. 2018;8:116-9.

Bell D, Kupferman ME, Williams MD, Rashid A, El-Naggar AK. Primary colonic-type adenocarcinoma of the base of the tongue: A previously unreported phenotype. Hum Pathol. 2009;40:1798-802.

Slova D, Paniz MA, Moisini I, Levi G, Urken M, Zevallos J, et al. Colonic-type adenocarcinoma of the base of the tongue: A case report of a rare neoplasm. Head Neck Pathol. 2012;6:250-4.

Smith SM, Old M, Iwenofu OH. Primary lingual colonic-type adenocarcinoma: a rare and emerging distinct entity. Head Neck Pathol. 2017;11:234-9.

Rahimi S, Akaev I, Repanos C, Brennan PA, Dubois JD. Primary intestinal-type adenocarcinoma of tongue: A case report with immunohistochemical and molecular profiles and review of the literature. Head Neck Pathol. 2017;11:186-91.

McDaniel AS, Burgin SJ, Bradford CR, McHugh JB. Pathology quiz case 2. diagnosis: primary colonic-type adenocarcinoma of the tongue. JAMA Otolaryngol Head Neck Surg. 2013;139:653-4.

Meyer I, Shklar G. Malignant tumors metastatic to mouth and jaws. Oral Surg Oral Med Oral Pathol. 1965;20:350-62.

Veeneklaas GMH. Pathogenesis of intrathoracic gastrogenic cysts. AMA Am J Dis Child. 1952;83: 500-7.

Christensen WN, Sternberg SS. Adenocarcinoma of the upper esophagus arising in ectopic gastric mucosa. Two case reports and review of the literature. Am J Surg Pathol. 1987;11:397-402.

Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893-917

Wenig BM. Atlas of head and neck pathology. 2nd ed. Philadelphia, PA: Saunders-Elsevier; 2008:121-4.

Riihimäki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K. Metastatic spread in patients with gastric cancer. Oncotarget. 2016;7(32):52307-16.

de Vries EJ, Johnson JT, Myers EN, Barnes EL, Mandell-Brown M. Base of tongue salivary gland tumors. Head Neck Surg. 1987;9:329-31.

Hassona Y, Hughes C, Prime SS. Metastatic tumors of the tongue. Oral Oncol. 2011;47:308-11.

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Published

2020-11-24

Issue

Vol. 6 No. 12 (2020): December 2020

Section

Case Reports