Evaluation of hearing acuity in patients with chronic renal failure by pure tone audiometry


  • Netra A. Pathak Department of ENT, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India
  • Sanjana V. Nemade Department of ENT, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India
  • Kiran J. Shinde Department of ENT, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India




Chronic kidney disease, CRF, Sensory neural hearing loss (SNHL) audiometry


Background: Hearing loss is common in patients with chronic renal failure. It is well known that chronic renal failure (CRF) causes different systemic and otorhinolaryngologic manifestations due to the accumulation of nitrogenous waste products. The aim of the study was to evaluate hearing threshold and the severity of hearing loss at different frequencies in patients of chronic renal failure (CRF), and to analyse the role of duration of disease on hearing threshold in patients of CRF.

Methods: Fifty two patients of CRF were included in the study. Pure tone audiometry was done in all cases.

Results: Majority of the patients were in 21 to 40 year age group (mean: out of 52 patients, 38 patients (73.07%) had sensorineural hearing loss and 14 patients (26.93%) had normal hearing. Majority of the patients with hearing loss had mild (44.73%) or moderate (42.11%) sensorineural hearing loss. On comparison of the mean hearing threshold Group II (duration of disease more than five years- 17 patients) showed a statistically significant difference (P<0.05) in mean hearing threshold at 250 Hz.

Conclusions: Hearing loss is present in majority of the patients of CRF. Most of the cases have mild to moderate sensorineural hearing loss. High frequency hearing loss in chronic renal failure is related to the duration of the disease, duration of haemodialysis’ and internal homeostasis, namely hyponatremia.


Chonchol M, Spiegel DM. The patients with Chronic Kidney disease. In: Manual of Nephrology. 7th ed. Philadelphia: Lippencott, Williams and Wilkins; 2009:185-188.

Mancini ML, Dello Strologo L, Bianchi PM, Tieri L, Rizzoni G. Sensorineural hearing loss in patients reaching chronic renal failure in childhood. Pediatr Nephrol. 1996;10:38-40.

Antonelli AR, Bonfiolii F, Garrubba V, Ghisellini M, Lamoretti MP, Nicolai P, et al. Audiological findings in elderly patient with chronic renal failure. Acta Otolaryngologica. 1991;476:54-68.

Kligerman AB, Solangi KB, Ventry IM, Goodman AI, Wesely SA. Hearing impairment associated with Chronic renal failure. Laryngoscope. 1981;91:583-92.

Bazzi C, Venturini C, Pagani C, Arrigo G, D’Amico G. Hearing loss in short and long term haemodialyzed patients. Nephrol Dial Transpl. 1995;10:1865-8.

Kusakari J, Kobayashi T, Rokugo M, Arakawa E, Ohyama K, Kawamoto K, et al. The inner ear dysfunction in hemodialysis patients. Tohoku J Exp Med. 1981;135:359-69.

Charachon R, Moreno-Ribes V, Cordinnier D. Deafness due to renal failure. Clinicopathological study. Ann Otolaryngol Chir Cervicofac. 1978;95:179-203.

Ozturan O, Lam S. The effect of hemodialysis on hearing using pure tone audiometry and distortion- product otoacoustic emissions. ORL J Otorhinolaryngol. 1998;60:306-13.

Gatland D, Tucker B, Chalstrey S, Keene M, Baker L. Hearing loss in chronic renal failure- threshold changes following haemodialysis’. J Royal Soc Med. 1991;84:587-9.

Johnson DW, Wathen RL, Mathog RH. Effect of hemodialysis on hearing threshold. ORL J Otorhinolaryngol. 1976;38:129-39.

Stavroulaki P, Nikolopoulos TP, Psarommatis I, Apostolopoulos N. Hearing evaluation with distortion product otoacoustic emissions in young patients undergoing hemodialysis. Clin Otolaryngol. 2001;26:235-42.

Brookes GB. Vitamin D deficiency and deafness 1984 update. Am J Otol. 1985;6:102-7.

Alder D, Fiehn W, Rirz E. Inhibition of Na+ K+ stimulated ATPase in cochlea of the guinea pig. A potential cause of disturbed inner ear function in terminal renal failure. Acta Otolaryngol. 1980;90:55-60.

Henrich W, Thompson P, Bergstrom L, Lum GM. Effect of dialysis on hearing acuity. Nephron. 1977;18:348-51.






Original Research Articles