Correlation of ABO blood group phenotype with atrophic rhinitis: an observational study

Authors

  • Abhinav Srivastava Department of ENT, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
  • Sunil K. S. Bhadouriya Department of ENT, RAMA Medical College, Hapur, Uttar Pradesh, India
  • Omkar N. Sinha Department of ENT, Rohilkhand Medical College, Bareilly, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20204627

Keywords:

Aetiology, Atrophic, Blood group, Ozaena, Rhinitis

Abstract

Background: Atrophic rhinitis is very common in India. All etiological factors are yet unknown.  Many studies have been conducted to find the relationship between ABO blood group and various systemic diseases but limited number of studies has been conducted to determine the association of ABO blood group with atrophic rhinitis. The present study therefore was performed to see the association between atrophic rhinitis and ABO blood group.

Methods: 100 patients of both genders clinically diagnosed with atrophic rhinitis were included in this study. Patients with nasal obstruction, nasal discharge and foul smelling from causes other than the atrophic rhinitis were excluded from the study.  

Results: Maximum number of cases 27 (27%) were between 21-30 years of age. The most common presenting symptom in our study was foul smell from nose in 100 cases (100%). Foetors, crusts and roomy nasal cavity were seen in majority of cases. Commonest organism identified in this study was Pseudomonas aeruginosa 37% followed by Klebsiella (31%). Out of 100 patients, 42 patients belonged to group O, 40 patients belonged to group B, 14 patients belonged to group A and only 4 patients belonged to group AB. Control population with blood group B comprises the maximum number of cases followed by blood group O. Percentage of patients with blood group O is higher in atrophic rhinitis as compared with control and the percentage of patients with blood group B is slightly higher in atrophic rhinitis as compared with control.

Conclusions: Our study concluded that no correlation exists between the ABO blood group and atrophic rhinitis.

References

Shehata MA. Atrophic rhinitis. Am J Otolaryngol.1996;17:(2):81-6.

Ruskin JL. A differential diagnosis and therapy of atrophic rhinitis and ozena. Arch Otolaryngol. 1932;15:222-57.

Zohar Y, Talmi YP, Strauss M, Finkelstein Y, Shvilli Y. Ozena revised. J Otolaryngol. 1990;19(5):345-9.

Lobo CJ, Hartley C, Farrington WT. Closure of the nasal vestibule in atrophic rhinitis: a new non-surgical technique. J Laryngol Otol. 1998;112:543-6.

Dutt SN, Kameswaran M. The aetiology and management of atrophic rhinitis. J Laryngol Otol. 2005;119(11):843-52.

Bunnag C, Jareoncharsri P, Tansuriyawong P, Bhothisuwan W, Chantarakul N. Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital. Rhinology. 1999;37(3):125-30.

Bernat I. Ozaena and iron deficiency. Br Med J. 1968;3:313-5.

Zakrzewski J. On the etiology of systemic ozena. Otolaryngologia Polska. 1993;47(5):452-8.

Amreliwala MS, Jain SKT, Raizada RM, Sinha V, Chaturvedi VN. Atrophic rhinitis: an inherited condition. Indian J Clin Pract. 1993;4:43-6.

Medina L, Benazzo M, Bertino G, Montecucco CM, Danesino C, Martinetti M, et al. Clinical, genetic and immunologic analysis of a family affected by ozaena. Eur Arch Otorhinolaryngol. 2003;260:390-4.

Moore EJ, Kern EB. Atrophic rhinitis: a review of 242 cases. Am J Rhinol. 2001;15:355-61.

Sharan R. Transplantation of maxillary sinus mucosa in atrophic rhinitis. Indian J Otolaryngol. 1978;30:14-6.

Sharma AN, Sardana DS. Stellate ganglion block in atrophic rhinitis. J Laryngol Otol. 1966;80:184-6.

Storry JR. Other blood group systems and antigens. In: Fung MK, Grossman BJ, Hillyer CD, Westhoff CM, eds. Technical Manual. 18th ed. Maryland: AABB; 2014:337-366.

Landsteiner K, Weiner AS. An agglutinable factor in human blood recognized by immune sera for rhesus blood. Proc Soc Exp Biol Med. 1940;43:223-4.

Eastlund T. The histo‑blood group ABO system and tissue transplantation. Transfusion. 1998;38:975‑88.

Aird I, Bentall HH, Roberts JA. A relationship between cancer of stomach and the ABO blood groups. Br Med J. 1953;1:799-801.

Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von Willebrand factor levels: From biology to clinical implications. Thromb J. 2007;5:14.

Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49:137‑49.

Aird I, Bentall HH, Mehigan JA, Roberts JA. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration. Br Med J. 1954;2:315-21.

Shimizu K, Hirose N, Ebihara Y, Arai Y, Hamamatsu M, Nakazawa S, et al. Blood type B might imply longevity. Exp Gerontol. 2004;39:1563-5.

Chen YL, Chen JC, Lin TM, Huang TJ, Wangz ST, Lee MF, et al. ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan. Clin Exp Allerg. 2005;35(7):926-32.

Falsarella N, Ferreira AI, Nakashima F, de Mattos Cde C, de Mattos LC. Evidence of an association between the O blood group and allergic rhinitis. Rev Bras Hematol Hemoter. 2011;33:444-8.

Chigira M. Origin of blood-group antigens: a self-declaration mechanism in somatic cell Society. Med Hypothes. 1996;46:290-4.

Cooling L Blood groups in infection and host susceptibility. Clin Microbiol Rev. 2015;28:801-70.

Bist SS, Bisht M, Purohit JP. Primary atrophic rhinitis: a clinical profile, microbiological and radiological study. ISRN Otolaryngol. 2012:404075.

Mishra S, Guru RK, Pati N. Clinicopathological study of atrophic rhinitis. J Evol Med Dent Sci. 2013; 2(8):899-902.

Han-Sen C. The ozena problem: clinical analysis of atrophic rhinitis in 100 cases. Acta Oto-Laryngologica. 1982;93(5-6):461-4.

Shreedharan SS, Prasad V, Shenoy VS, Kamath PM. A clinical study on atrophic rhinitis, its management and surgical outcome. Gen Med. 2015;3:1000155.

Jain SKT, Amreliwala MS, Sinha V, Raizada RM, Chaturvedi VN. Clinical profile of atrophic rhinitis with special reference to the status of maxillary sinuses. Int J Otorhinolaryngol Head Neck Surg. 1996;48(1):19-24.

Gadre KC, Bhargava KB, Pradhan RY, Lodaya JD, Ingle MV. Closure of the nostrils (Young’s operation) in atrophic rhinitis. J Larynogol Otol. 1971;85:711-8.

Kameswaran M. Fibre-optic endoscopy in atrophic rhinitis. J Laryngol Otol. 1991;105:1014-7.

De Sk. Fundamental of ear, nose and throat and head and neck surgery. 8th edn. The new book stall: Kolkata; 2005:164-165.

Hilal SA, Hussona AA, Alamar RJ. Characteristics of atrophic rhinitis in Iraqi patients at Thi-Qar Province. Thi-Qar Med J. 2010;4(4):31-8.

Downloads

Published

2020-10-23

Issue

Section

Original Research Articles