Published: 2020-09-23

Lymphoepithelial cell carcinoma of larynx masquerading as squamous cell carcinoma

Subbiah Shanmugam, Sujay Susikar, T. Bharanidharan, Venkatachalam Veerappan


Lymphoepithelial carcinoma is one of the common neoplasms seen to occur in nasopharyngeal subsite. Lymphoepithelial carcinoma (LEC) of the larynx is an uncommon entity; with 34 such cases reported in literature. Lymphoepithelial carcinoma (LEC) seems to behave in a fashion similar to nasopharyngeal carcinoma, except that most cases have not been associated with Epstein barr virus (EBV). We describe this patient with lymphoepithelial carcinoma (LEC) of supraglottic larynx who was treated with total laryngectomy and adjuvant radiotherapy and is on regular follow-up showed no evidence of local or distant metastasis.


Lymphoepithelial carcinoma, Supraglottic larynx, Radiotherapy, Total laryngectomy, Epstein barr virus

Full Text:



Tsai ST, Jin YT, Su IJ. Expression of EBER1 in primary and metastatic nasopharyngeal carcinoma tissues using in situ hybridization: a correlation with WHO histologic subtypes. Cancer: Interdis Int J Ame Canc Soc. 1996;77(2):231-6.

Vasef MA, Ferlito A, Weiss LM. Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein Barr virus. Anna Otology, Rhino & Laryng. 1997;106(4):348-56.

WeissLM, Gaffey MJ, Shibata D. Lympho-eptihelioma likecarcinoma and its relationship to the Epstein-Barr virus. Am J Clin Pathol. 1991;96: 156-8.

Iezzoni JC, Gaffey MJ, Weiss LM. The role of Epstein Barr virus in lymphoepithleioma like carcinomas. Am J Clin Pathol. 1995;103:308– 15.

Wassef M, Le Charpentier Y, Monteil JP et al. undifferentiated carcinoma with lymphoid stroma (undifferentiated carcinoma nasopharyngeal type?): optical, electron microscopical and immune fluorescence study. Bull Cancer. 1982;69:11–21.

HildermanWc, Gordon Js, Large Hl Jr, et al. Malignant lymphoepithelial lesion with carcino matous component apparently arising in parotid gland. A malignant counterpart of benign lymphoepithelial lesion?. Cancer. 1962;15:606-610.

MacMillan C, Kapadia SB, Finkelstein SD, et al. Lymphoepithelial carcinoma of the larynx and hypopharynx: study of eight cases with relationship to Epstein-Barr virus and p53 gene alterations, and review of the literature. Hum Pathol. 1996; 27(11):1172-1179.

Sone M, Nakashima T, Nagasaka T, et al. Lympho- epithelioma like carcinoma of the larynx associated with an Epstein-Barr viral infection. Otolaryngol Head Neck Surg. 1998; 119(1):134-137.

Toker C, Peterson DW. Lymphoepithelioma of the vocal cord. Arch Otolaryngol. 1978;l04:161-162.

Hammas N, Benmansour N, El Alami El Amine et al. Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx. BMC Clin Pathol. 2017; 17:24.