Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India


  • Vidya Rokade Department of ENT, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India
  • Kiran J. Shinde Department of ENT, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India
  • Girishkumar R. More Department of ENT, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India



Sinonasal mass, Polyp, Neoplastic, Retrospective


Background: A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.

Methods: This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.

Results: A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.

Conclusions: Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2nd to 4th decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.


Author Biographies

Vidya Rokade, Department of ENT, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India


Kiran J. Shinde, Department of ENT, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India


Girishkumar R. More, Department of ENT, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India




Radenne F, Lambin C, Vandezande L-M, Tillie-Leblond I, Darras J, Tonnel AB et al. Quality of life in nasal polyposis. J Allergy Clin Immunol. 1999;103:79-84.

Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol. 1999;28(4):717-22.

Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc. 1996;17(5):231-6.

Chavan SS, Deshmukh S, Pawar V, Sarvade K, Kirpan V, Kumbhakarna NR et al. Case study of clinicopathologicalcorrelation of benign sinonasal masses. World Articles Ear Nose Throat. 2012;5(1).

Kale USU, Mohite U, Rowlands DAB, Drake‐Lee. Clinical and histopathologicalcorrelation of nasal polyp: are there any surprises? Clin Otolaryngol Allied Sci. 2001;26(4):321-3.

Diamantopoulus I, Jones NS, Lowe J. All nasal polypsneed histopathological examination: an audit-based appraisal ofclinical practice. J Laryngol Otol. 2000;114:755-9.

Zafar U, Khan N, Afroz N, Hasan SA. Clinicopathological study of non-neoplastic lesions of nasal cavity and paranasal sinuses. Indian J Pathol Microbiol 2008;51(1):26-9.

Bakari A, Afolabi OA, Adoga AA, Kodiya AM, Ahmad BM. Clinico-pathological profile of sinonasal masses: an experience in national ear care center Kaduna, Nigeria. BMC Research Notes. 2010;3:186.

Flint P, Haughey B, Lund V, Niparko J, Robbins K, Regan J et al. ThomasCummings Otorhinilaryngology, Head and Neck Surgery, 6th Edition. 2014;3:3624

Watkinson JC, Clarke RW. Scott - Browns Otorhinolaryngology, Head and Neck Surgery, CRC publication 7th Edi. 2018;4356.

Humayun AHM, Zahurul Huq AHM, Ahmed SMT, Kamal MS, Khin KU, Bhattacharjee N. Clinicopathological study of sinonasal masses. Bangladesh J Otorhinolaryngol. 2010;16:15-22.

Casale M, Pappacena M, Potena M, Vesperini E, Ciglia G, Mladina R et al. Nasal polyposis: from pathogenesis to treatment, an update. Inflamm Allergy Drug Targets. 2011;10(3):158-63.

Dasgupta A, Ghosh RN, Mukherjee C. Nasal polyps-Histopathologic spectrum. Indian J Otolaryngol Head Neck Surg. 1997;49:32-6.

Pradhananga RB, Adhikari P, Thapa NM, A Shrestha, B Pradhan. Overview of nasal masses. J Inst Med. 2008;30:13-16.

Morelli L, Polce M, Piscioli F, Nonno FD, Covello R, Brenna A. Human nasal rhinosporidiosis: an Italian case report Diagnostic Pathology. 2006;1:25.

Webb CG, Porter G, Sissons GRJ. Cavernous hemangioma of the nasal bones: an alternative management option. J Laryngol Otol. 2000;114:287-9.

Syrjänen KJ. HPV infections in benign and malignant sinonasal lesions. J Clin Pathol. 2003;56:174-81

Iwata N, Hattori K, Tsujimura T. Hemangioma of the nasal cavity: a clinicopathological study. Auris Nasus Larynx. 2002;29:335-9.

Lund VJ, Stammberger H, Nicolai P. European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinology. 2010;48(22):1-143.

Califano J, Koch W, Sidransky D, Westra WH. Inverted sinonasal papilloma: a molecular genetic appraisal of its putative status as a precursor to squamous cell carcinoma. Am J Pathol. 2000;156(1)333-7.

Muir CS, Nectoux J. Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. Clin Otolaryngol Allied Sci. 1980;5(3):195-211.

Fasunla AJ, Lasisi AO. Sinonasal malignancies: a 10-year review in a tertiary health institution. J Natl Med Assoc. 2007;99:1407-10.

Weymuller EA, Gal TJ. Neoplasms of the nasal cavity. In: Cummings CW, Flint PW, Harker LA. editors. Otolaryngology- Head and Neck surgery. 4th ed. Mosby; 2005.

Svane-Knudsen V, Jorgensen KE, Hansen O, Lindgren A, Marker P. Cancer of the nasal cavity and paranasal sinuses: a series of 115 patients. Rhinology. 1998;36(1):12-4.

Zyłka S, Bień S, Kamiński B, Postuła S, Ziołkowska M. Epidemiology and clinical characteristics of the sinonasal malignancies. Otolaryngol Pol. 2008;62:436-41.

Frosini P, Picarella G, De Campora E. Antrochoanal polyp: analysis of 200 cases. Acta Otorhinolaryngol Ital. 2009;29:21-6.

Lathi A, Syed AMM, Krishna PS. Acta Otorhinolaryngologica Italica. 2011;31(6):372-7.

Tondon PL, Gulati J, Mehta N. Histological study of polypoidal lesions in the nasal cavity. Indian J Otolaryngol. 1971;13:3-11.

Sharma D, Sharma N, Sharma V. Sinonasal Cancers: Diagnosis and Management, Challenging Issues on Paranasal Sinuses. Intech Open. 2019.






Original Research Articles