Human rhinosporidiosis: still an elusive disease
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20203588Keywords:
Rhinosporidiosis, Rhinosporidium seeberi, Recurrence, MesomycetozoeaAbstract
Rhinosporidiosis is a granulomatous infection of the mucous membrane caused by Rhinosporidium seeberi. It usually affects the nasal and nasopharyngeal mucosa but sometimes involve extra-nasal sites such as lips, buccal mucosa, palate, larynx, trachea, lacrimal sac, skin, scalp, penis, urethra, vulva and bone. The natural habitat of this organism is water and the infection probably spreads via trans-epithelial penetration. Histopathological examination confirms the diagnosis. The treatment of choice is complete surgical excision with cauterization of the base but the medical treatment shows limited efficacy. The patient of disseminated rhinosporidosis does not respond to the conventional treatment such as surgical excision and dapsone and with amphotericin B also proved futile result. This infection is usually overlooked, despite R. seeberi being endemic in tropical country like India. Due to the negligence in the diagnosis and taxonomic enigma of rhinosporidiosis, here we discuss the details of its epidemiology, etiopathology, clinical presentations, diagnosis and current treatment. Because rhinosporidiosis is relatively rare, we hope this review article will serve as aid and guide to the medical community for helping further research.
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Kaushal S, Mathur SR, Malik SR, Ramah M. Disseminated cutaneous, laryngeal, nasopharyngeal and recurrent obstructive nasal rhinosporidiosis in an immunocompetent adult: a case report and review of literature. Int J Dermatol. 2011;50:340-2.
Herr RA, Ajello L, Taylor JW, Arseculeratne SN, Mendoza L. Phylogenetic analysis of Rhinosporidium seeberi’s 18S small-sub unit ribosomal DNA groups this pathogen among members of the protistan Mesomycetozoa clade. J Clin Microbiol. 1999;37:2750-4.
Lupi O, Tyring SK, McGinnis MR. Tropical dermatology, fungal tropical disease. J Am Acad Dermatol. 2005;53:931.
Kameswaran S, LakshmananM. Rhinosporidiosis. ln: Karncswaran S, Laksluna nan M, eds . ENT Disorders in a Tropieal Environment. Chennai, India: MERF Publications. 1999:19-34.
Seeber GR. Un nuevo esporozoario parasito de l hombre: Doscasos eneon trades en polipas nasales [thesis]. Bueno sAires: Universidad Nacional de Buenos Aires. 1900.
Ashworth JH. Rhinosporidiumsccbcri (Wernickc, 1903) with special refere nce to its sporulation and affini ties. Trans R Soe Edinburgh. 1923;53:301-42.
Karuna ratne WA. Rhinos poridiosis in Man. London. Athlone Press;1964.
Rameshkumar A, Gnanaselvi UP, Dineshkumar T, Raghuram PH, Bharanidharan R, Rajkumar K. Rhinosporidiosis presenting as a facial swelling: a case report. Journal of international oral health. 2015;7(2):58.
Salazar Campos MC, Surka J, Garcia Jardon M, Bustamante N. Ocular rhinosporidiosis. S Afr Med J. 2005;95:950-2.
Sudasinghe T, Rajapakse RP, Perera NA, Kumarasiri PV, Eriyagama NB, Arseculeratne SN. The regional sero-epidemiology of rhinosporidiosis in Sri Lankan humans and animals. Acta Trop. 2011;120:72-81.
Arseculeratne SN. Rhinosporidiosis: what is the cause?. Curr Opin Infect Dis. 2005;18(2):113-8.
Kuriakose ET. Oculosporidiosis: rhinosporidiosis of the eye. Br J Ophthalmol. 1963;47:346-9.
Mukherjee B, Mohan A, Sumathi V, Biswas J. Infestation of the lacrimal sac by Rhinosporidium Seeberi: a clinicopathological case report. Indian J Ophthalmol. 2013;61:588-90.
Vilela R, Mendoza L. The taxonomy and phylogenetics of the human and animal pathogen Rhinosporidium seeberi: a critical review. Rev Iberoam Micol. 2012;29:185-99.
Alhuwalia KB, Maheshwari N, Deka RC. Rhinosporidiosis: a study that resolves etiologic controversies. Am J Rhinol. 1997;11:479-83.
Herr RA, Ajello L, Taylor JW, Arseculeratne SN, Mendoza L. Phylogenetic analysis of Rhinosporidium seeberi’s 18S small-sub unit ribosomal DNA groups this pathogen among members of the protistan Mesomycetozoa clade. J Clin Microbiol. 1999;37:2750-4.
Herr RA, Ajello L, Taylor JW, Arseculeratne SN, Mendoza L. Phylogenetic analysis of Rhinosporidium seeberi’s 18S small‑subunit ribosomal DNA groups this pathogen among members of the protoctistan mesomycetozoa clade. J Clin Microbiol. 1999;37:2750-4.
Varshney S, Bist SS, Gupta P, Gupta N, Bhatia R. Lacrimal sac diverticulum due to rhinosporidiosis. Indian J Otolaryngol Head Neck Surg. 2007;59:353-6.
David SS, Sivaramasubrahmanyam P. Ocular rhinosporidiosis, a study of twenty cases. Indian J Ophthalmol. 1973;21:204-7.
Rath R, Baig SA, Debata T. Rhinosporidiosis presenting as an oropharyngeal mass: a clinical predicament? J Nat Sci Biol Med. 2015;6:241-5.
Tiwari D, Bakshi SS, Das S, Gopalakrishnan S. Disseminated rhinosporidiosis. Arch Med Health Sci.2019;7:84-6.
Nayak S, Rout TK, Acharjya B, Patra MK. Subcutaneous rhinosporidiosis. Indian J Dermatol. 2008;53:41-3.
Prabhu SM, Irodi A, Khiangte HL, Rupa V, Naina P. Imaging features of rhinosporidiosis on contrast CT. Indian J Radiol Imaging. 2013;23:212-8.
Saha J, Basu AJ, Sen I, Sinha R, Bhandari AK, Mondal S. Atypical presentations of rhinosporidiosis: A clinical dilemma? Indian J Otolaryngol Head Neck Surg. 2011;63:243-6.
Kumari R, Laxmisha C, Thappa DM. Disseminated cutaneous rhinosporidiosis. Dermatol Online J. 2005;11:19.
Mandalik GS. A record of rhinosporidial polyp: with some observation on mode of infection. Indian Med Gaz. 1937;72:143-7.
Panda S, Lenka S, Padhiary SK, Sahoo SR, Srivastava G. Rhinosporidiosis in the parotid duct: a rare case report. J Investig Clin Dent. 2013; 4(4):271-4.
Dutta S, Haldar D, Dutta M, Barik S, Biswas KD, Sinha R. Socio-demographic correlates of rhinosporidiosis: A hospital-based epidemiologic study in Purulia, India. Indian Journal of Otolaryngology and Head & Neck Surgery. 2017; 69(1):108-12.
Arseculeratne SN. Recent advances in rhinosporidiosis and Rhinosporidium seeberi. Indian J Med Microbiol. 2002;20:119-31.
Sinha A, Phukan JP, Bandyopadhyay G, Sengupta S, Bose K, Mondal RK, et al. Clinicopathological study of rhinosporidiosis with special reference to cytodiagnosis. Journal of Cytology/Indian Academy of Cytologists. 2012;29(4):246.
Arseculeratne SN. Recent advances in rhinosporidiosis and Rhinosporidium seeberi. Indian J Med Microbiol. 2002;20:119-31.
De Silva NR, Huegel H, Huegel DN, Arseculeratne SN, Kumarasiri R, Gunawardena S, et al. Cell-mediated immune responses (CMIR) in human rhinosporidiosis. Mycopathologia. 2001;152(2):59.
Singh CA, Sakthivel P. Rhinosporidiosis. N Engl J Med. 2019;380(14):1359.
Swain SK, Behera IC, Mohanty JN. Mucormycosis in head-and-neck region–Our experiences at a tertiary care teaching hospital of Eastern India. Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery. 2019;3(2):58.
Nerurkar NK, Bradoo RA, Joshi AA, Shah J, Tandon S. Lacrimal sac rhinosporidiosis: a case report. Am J Otolaryngol. 2004;25:423-5.
Khan I, Gogia S, Agarwal A, Swaroop A. Recurrent Rhinosporidiosis: Coblation Assisted Surgical Resection-A Novel Approach in Management. Case reports in otolaryngology. 2014;2014.
Vinod MK, Kaur A, Devgan K, Singh J. Rare case of rhinosporidiosis: a case report from Jammu. International Journal of Otorhinolaryngology and Head and Neck Surgery. 2017;3(1):148.
Tiwari R. Rhinosporidiosis: A Riddled Disease of Man and Animals. Advances in Animal and Veterinary Sciences. 2015;3(2):55.
Job A, Venkateswaran S, Mathan M, Krishnaswami H, Raman R. Medical therapy of rhinosporidiosis with dapsone. J Laryngol Otol. 1993;107 (9):809-12.
Madke B, Mahajan S, Kharkar V, Chikhalkar S, Khopkar U. Disseminated cutaneous with nasopharyngeal rhinosporidiosis: light microscopy changes following dapsone therapy. Australas J Dermatol. 2011;52:4-6.
Swain SK, Debta P, Sahu MC, Mohanty JN. Otomycosis due to Aspergillus versicolor. International Journal of Health & Allied Sciences. 2020;9(2):192.
Swain SK, Sahu MC, Debdta P, Baisakh MR. Primary fungal laryngitis: An overlooked clinical entity. Apollo Med. 2019;16:11-5.
Swain SK, Nahak B,Sahu MC.Fungal laryngitis in asthmatic boy treated with inhalatory corticosteroids:A Case Report.Pediatria polska. 2017;92:453-6.
Nair KK. Clinical trial of diaminodiphenylsulphone [DDS] in nasal and nasopharyngeal rhinosporidiosis. Laryngoscope.1979;89:291-5.
