A comparative study to assess the efficacy of fluticasone and mometasone in allergic rhinitis

Authors

  • Waqar Ul Hamid Department of ENT and HNS, Government Medical College, Srinagar, Jammu and Kashmir, India
  • Deepshikha Sumbria Department of Health and Family Welfare, Jammu and Kashmir, India
  • Ihsan Ali Department of ENT and HNS, Government Medical College, Srinagar, Jammu and Kashmir, India
  • Rauf Ahmad Department of ENT and HNS, Government Medical College, Srinagar, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20203503

Keywords:

Fluticasone propionate, Mometasone furoate, Allergic rhinitis, Total nasal symptom score questionnaire

Abstract

Background: Allergic rhinitis is the most prevalent of allergic diseases in the world. Pharmacotherapy remains the mainstay of treatment.  Nasal corticosteroids being the most applicable drugs for its treatment. The objective of this study was to compare the efficacy of fluticasone propionate (FP) and mometasone furoate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.

Methods: A prospective, randomized, open-label, parallel-group, comparative study was conducted among 80 allergic rhinitis patients fulfilling the inclusion and exclusion criteria. They were randomly assigned to two groups: FP and MF groups. FP group received 200 µg dose of FP nasal spray (1 spray/nostril) daily and the MF group received 100 µg dose of MF nasal spray (1 spray/nostril) daily for 8 weeks. The effects of the two agents were compared based on TNSS questionnaire in 0, 4 and 8 weeks after the beginning of the treatment.  

Results: At the end of eight weeks of treatment, both groups showed statistically significant (p<0.005) improvements from their baseline TNSS. Mean TNSS was reduced from to 9.46 to 2.716 in FP group and from 10.18 to 2.504 in MF group.

Conclusions: Both the groups showed a significant therapeutic benefit in patients with allergic rhinitis. Even though, the difference between the two is not significant for 8 weeks therapy.   

Author Biographies

Waqar Ul Hamid, Department of ENT and HNS, Government Medical College, Srinagar, Jammu and Kashmir, India

Senior Resident
Department of ENT & HNS

Deepshikha Sumbria, Department of Health and Family Welfare, Jammu and Kashmir, India

Medical Officer

Ihsan Ali, Department of ENT and HNS, Government Medical College, Srinagar, Jammu and Kashmir, India

Associate Professor

Department of ENT & HNS

Rauf Ahmad, Department of ENT and HNS, Government Medical College, Srinagar, Jammu and Kashmir, India

Professor and Head of the Department

Department of ENT & HNS

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Published

2020-08-25

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Original Research Articles