Laryngeal amyloidosis: a case report

Authors

  • Jameel N. Alswaiheb Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia
  • Mohammed A. Motiwala Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia
  • Abdulmalik Alkhodair Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia
  • Abdulrahman Aljadoa Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia
  • Ghada Alhindi Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia
  • Jose Cletus Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20202793

Keywords:

Laryngeal tumor, Amyloidosis, Isolated laryngeal mass

Abstract

Amyloidosis is a rare, benign, slowly progressive disease characterized by extracellular accumulation of amyloid in different tissues of the body. It accounts for 0.2-1.2% of benign laryngeal tumors and usually presents as an isolated localized laryngeal amyloidosis, but can also be part of systemic amyloidosis. A 26 years old female with history of gradually developing, persistent hoarseness, and progressive dyspnea since 1 year, worsened over the past three days. Outpatient Department based endoscopy showed bilateral mobile, thickened vocal cords with subglottic edematous thickness. Computed tomography scan showed symmetrical thickening of bilateral vocal cord, causing glottic narrowing about 70% on the AP view and about 50% on the lateral view and no cartilage invasion or lymphadenopathy. Microlaryngoscopy and biopsy of the specimen were performed and histopathology confirmed the diagnosis of amyloidosis with Congo red stain. Patient was managed by surgical excision of the mass and long term follow-up. To rule out systemic amyloidosis patient is referred to rheumatology clinic and hematology clinic for further evaluation and management. Histopathological examination of the involved tissue confirms the diagnosis, and long term follow up is mandatory in the management of amyloidosis.

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Author Biography

Jameel N. Alswaiheb, Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia

Assistant consultant,

Department of Otorhinolaryngology, Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia

References

Saleem T, Fatima S, Ghaffar S, Aftab K, Awan S. Two cases of primary laryngeal amyloidosis. J Pak Med Assoc. 2009;59(11):789-91.

Thompson LDR, Derringer GA, Wenig BM. Amyloidosis of the larynx: a clinicopathologic study of 11 cases. Mod Pathol. 2000;13(5):528-35.

Vanessa C, Kate G, David H. Primary localized laryngeal amyloidosis presenting with dysphonia: a case report. J Surg Case Rep. 2012;2012(11):rjs005.

Sonkhya N, Mittal P, Sonkhya D, Mehta R. Localized laryngeal amyloidosis: a case report and review of literature. Global Adv Res J Med Med Sci. 2012;1(3):45-8.

Alaani A, Warfield AT, Pracy JP. Management of laryngeal amyloidosis. J Laryngol Otol. 2004;118(4):279-83.

Yiotakis I, Georgolios A, Charalabopoulos A, Hatzipantelis P, Golias C, Charalabopoulos K, et al. Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report. J Med Case Rep. 2009;3(1):9049.

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Published

2020-06-25

How to Cite

Alswaiheb, J. N., Motiwala, M. A., Alkhodair, A., Aljadoa, A., Alhindi, G., & Cletus, J. (2020). Laryngeal amyloidosis: a case report. International Journal of Otorhinolaryngology and Head and Neck Surgery, 6(7), 1357–1360. https://doi.org/10.18203/issn.2454-5929.ijohns20202793

Issue

Section

Case Reports