Pediatric extramammary myofibroblastoma in the head and neck region: a case report

Sunil K. C., B. Y. Praveen Kumar, Varna Ravindran M. K., Kiran Mali


A rare form of mesenchymal neoplasm that typically presents in older men and women is mammary myofibroblastoma. Even so rarely, these benign tumours may occur outside of the breasts in soft tissues; which then are called mammary-type myofibroblastoma. There can be marked variability in the histological composition of these benign spindle cell tumours. Along the milk line is the commonest presentation of these extramammary myofibroblastoma. Here we have an 8 years old female patient presented to the department of otorhinolaryngology with a painless, fusiform swelling over the right lateral aspect of tongue in the past 6 months. Intra oral examination revealed a non-tender, non-ulcerated fusiform shaped mass approximately 3×2 cm firm in consistency arising from the right lateral border of the tongue. FNAC was done which showed spindle cell tumour tongue. The lesion was diagnosed as mammary type myofibroblastoma on immunohistochemistry.


Mammary type myofibroblastoma, Head and neck myofibroblastoma, Pediatric myofibroblastoma

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Wargotz ES, Weiss SW, Norris HJ. Myofibroblastoma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor. Am J Surg Pathol. 1987;11:493-502.

Menamin ME, Fletcher CD. Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. Am J Surg Pathol. 2001;25:1022-9.

Arsenovic N, Abdulla KE, Shamim KS. Mammary-type myofibroblastoma of soft tissue. Indian J Pathol Microbiol. 2011;54:391-3.

Mukonoweshuro P, Cormick MF, Rachapalli V, Natale S, Smith ME. Paratesticular mammary-type myofibroblastoma. Histopathology. 2007;50:396-7.

Menamin ME, Schryver DK, Fletcher CD. Fibrous lesions of the breast: a review. Int J Surg Pathol. 2000;8:99-108.

Mackay B, Ordonez NG, Salter JE. Myofibroblastoma of the axilla. Ultrastruct Pathol. 1995;19:265-8.

Hox V, Poorten VV, Delaere PR, Hermans R, Rychter DM, Sciot R. Extramammary myofibroblastoma in the head and neck region. Head Neck. 2009;31:1240-4.

Scotti C, Camnasio F, Rizzo N, Fontana F, Cobelli DF, Peretti GM, et al. Mammary-type myofibroblastoma of popliteal fossa. Skeletal Radiol. 2008;37:549-53.

Millo NZ, Yee EU, Mortele KJ. Mammary-type myofibroblastoma of the liver: multi-modality imaging features with histopathologic correlation. Abdom Imaging. 2014;39:482-7.

Ghafar JA, Din NU, Ahmed Z, Billings SD. Mammary-type myofibroblastoma of the right thigh: a case report and review of the literature. J Medical Case Reports. 2015;9(1):126.

Howitt BE, Fletcher CDM. Mammary - type myofibroblastoma clinicopathologic characteri-zation in a series of 143 cases. Am J Surg Pathol. 2016;40(3):361-7.