Clinical profile of the patients with oral squamous cell carcinoma: a tertiary institutional study


  • Deep Jyoti Department of ENT, GMC Jammu, Jammu and Kashmir, India
  • Arti . Department of ENT, GMC Jammu, Jammu and Kashmir, India
  • Padam Jamwal Department of ENT, GMC Jammu, Jammu and Kashmir, India
  • Sonika Kotwal Department of ENT, GMC Jammu, Jammu and Kashmir, India
  • Kunzes Dolma Department of ENT, GMC Jammu, Jammu and Kashmir, India



Oral cavity, Squamous cell carcinoma, Tongue, Risk factors


Background: Oral cancer consists of a group of neoplasms affecting any region of the oral cavity. This term is commonly used interchangeably with oral squamous cell carcinoma (OSCC), representing the most frequent of all oral neoplasms. Factors affecting the development of the oral squamous cell carcinoma are tobacco use, alcohol consumption, low socio-economic status, poor hygiene, poor diet, viral infection like HPV, ill-fitting dentures, jagged teeth.

Methods: An institution based retrospective observational study was conducted in the department of ENT, GMC Jammu, including the records of the patients with oral squamous cell carcinoma admitted from June 2016 to July 2019. 80 patients of oral carcinoma were included in the study.

Results: Male to female ratio was 5.1:1. Mean age of presentation was 49.2±4.1 with most of the cases presenting in the 6th decade. 27 (33.75%) patients had history of chewing tobacco alone, 17 (21%) had smoking with chewing tobacco and 10 (12.5 %) smoking with alcohol. 52% patients presented with growth of tongue (52%) followed by buccal mucosa (17.5%) and other sites. Histopathological grading of OSCC showed predominance of well differentiated cancer in 44 cases (55%).

Conclusions: Cases of OSCC are increasing day by day in young generation due to increasing exposure to the risk habits which are easily accessible to them.

Author Biography

Deep Jyoti, Department of ENT, GMC Jammu, Jammu and Kashmir, India

Senior Resident, department of ENT, GMC, Jammu


Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck. 2007;29:779-92.

Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of Worldwide Burden of Cancer. Int J Cancer. 2010;127(12):2893-917.

Majumdar B, Patil S, Sarode SC, Sarode GS, Rao RS. Clinicopathological prognosticators in oral squamous cell carcinoma: An update. Translational Res Oral Oncol. 2017;2:1-14.

Neville BW, Damm DO, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th Ed. Philadelphia: Saunders 2016.

Sahaf R, Naseem N, Rehman A, Anjum R, Nagi AH. EMMPRIN (CD 147) as a potential predictor of oral squamous cell carcinoma progression: A study from Pakistan. J Histol Histopathol. 2017;4:8.

Scully C. Oral Cancer Aetiopathogenesis; Past, Present and Future Aspects. Med Oral Patol Oral Cir Bucal. 2011;16:306‑11.

Chaturvedi P. Effective strategies for oral cancer control in India. J Cancer Res Ther. 2012;8(1):55-6.

Choi S, Myers JN. Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy. J Dent Res. 2008;87:14-32.

Toporcov TN, Znaor A, Zhang ZF, Yu GP, Winn DM, Wei Q, Et Al. Risk Factors for Head and Neck Cancer in Young Adults: A Pooled Analysis in The INHANCE Consortium. Int J Epidemiol. 2015;44:169‑85.

Ranganathan K, Rooban T, Rao UM. Oral Squamous Cell Carcinoma in Patients with And Without Predisposing Habits in Glossal And Extra‑Glossal Site: An Institutional Experience in South India. Indian J Cancer. 2015;52:625‑7.

Aruna DS, Prasad KV, Shavi GR, Ariga J, Rajesh G, Krishna M et al. Retrospective study on risk habits among oral cancer in Karnatka cancer therapy and research institute, Hubli, India. Asian Pac J Cancer Prev. 2011;12:1561-6.

Misra S, Chaturvedi A, Misra NC, Johnson CD, Taylor I. Oral carcinoma. Rec Advan Surg. 2002;5(1):71-86.

Shenoi R, Devrukhar V, Chaudhari, Sharma BK, Sapre SB, Chikhale A. Demographic and clinical profile of oral squamous cell carcinoma patients: A retrospective study. Indian J Cancer. 2012;49:215-9.

Chandolia B, Basu SK, Kumar M. Can MMP-9 Be A Prognosticator Marker for Oral Squamous Cell Carcinoma. J Clin Diagn Res. 2016;10(1):9-13.

Wahi PN. Histological Typing of Oral and Oropharyngeal Tumours. Geneva: World Health Organization, 1971.

Warnakulasuriya S. Global Epidemiology of Oral and Oropharyngeal Cancer. Oral Oncol. 2009;45:309-16.

La Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G, Negri E. Epidemiology and Prevention of Oral Cancer. Oral Oncol. 1997;33:302-12.

Tondon A, Tandon A, Bordoloi B, Jaiswal R, Srivastava1 A, Bhushan RS, Shafique U et al. Demographic and Clinicopathological Profile of Oral Squamous Cell Carcinoma Patients of North India: A Retrospective Institutional Study. SRM J Res Dental Sci. 2018;9(3):114-8.

Sharma P, Saxena S, Aggarwal P. Trends in the epidemiology of oral squamous cell carcinoma in western UP: An institutional study. Indian J Dent Res. 2010;21:316-9.

Addala L, Pentapati CK, Reddy Thavanati PK, Anjaneyulu V, Sandhnani MD. Risk factor profiles of head and neck cancer patients of Andhra Pradesh, India. Indian J Cancer. 2012;49:215-9.

Smitha T, Mohan CV, Hemavathy S. Clinicopathological Features of Oral Squamous Cell. J Dr. NTR Univ health Sci. 2017;6(1):29-34.

Ogden GR. Alcohol and Oral Cancer. Alcohol. 2005;35:169-73.

Siriwardena BS, Tilakaratne A, Amaratunga EA, Tilakaratne WM. Demographic, Aetiological and Survival differences of Oral Squamous Cell Carcinoma in The Young and The Old in Sri Lanka. Oral Oncol. 2006;42:831‑6.

Andrews E, Seaman WT, Webster‑Cyriaque J. Oropharyngeal Carcinoma in Non‑Smokers and Non‑Drinkers: A Role For HPV. Oral Oncol. 2009;45:486‑91.

Andisheh-Tadbir A, Mehrabani D, Heydari ST. Epidemiology of Squamous Cell Carcinoma of The Oral Cavity in Iran. J Craniofac Surg. 2008;19:1699-702.

Jayasooriya PR, Pitakotuwage TN, Mendis BR, Lombardi T. Descriptive Study Of 896 Oral Squamous Cell Carcinomas from The Only University Based Oral Pathology Diagnostic Service in Sri Lanka. BMC Oral Health. 2016;16:1.

Khan Z, Tonnies J, Muller S. Smokeless Tobacco and Oral Cancer in South Asia: A Systematic Review with Meta-Analysis. J Cancer Epidemiol. 2014;39:4.

Rao SVK, Mejija C, Roberts TK, Logan R. Epidemiology of Oral Cancers in Asia in the Past Decade- An Update. Asian Pac J Cancer Prev. 2013;14(10):5567-77.

Frank DK, Sessions RB. Management of the neck surgery. In: Harrison LB, Sessions RB, Hong WK(Eds.), Head and Neck Cancer: A Multidisciplinary Approach. 3rd Ed. Philadelphia: Lippincott, William And Wilkins; 2009:181-200.

Wang C. Carcinoma of the Oropharynx. In: Wang C, ed. Radiation Therapy for Head and Neck Neoplasms. 3rd ed. New York, NY: Wiley-Liss; 1997: 387.

Ridge JA, Damiel G, Haller, Kevin A, William J, Hoskins. Cancer Management: A Multidisciplinary Approach Medical, Surgical, and Radiation Oncology. In: Head and Neck Tumors, Ed. L.D.W. Camphausen. Cancer Network Home of The Journal Oncology: Cancer Network 2013;21(9):1084.






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