DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20194960

A rare case of collision tumor of thyroid gland: simultaneous occurrence of calcitonin negative medullary thyroid carcinoma and papillary thyroid carcinoma

Savita Saharan, Ranjana Solanki, Deepak Saharan

Abstract


Medullary thyroid carcinoma and papillary thyroid carcinoma are two distinct types of thyroid carcinoma having different cellular origin. The simultaneous occurrence of two distinct neoplasms termed “collision tumour” and it is a rare entity. Sometimes the medullary component does not show calcitonin positivity and hence this becomes a very rare entity. Herein we describe a very rare case of simultaneous occurrence of calcitonin negative medullary thyroid carcinoma and papillary thyroid carcinoma.


Keywords


Thyroid collision tumor, Calcitonin, Negative medullary thyroid carcinoma

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References


Parker LN, Kollin J, Wu SY, Rypins EB, Juler GL. Carcinoma of the thyroid with a mixed medullary, papillary, follicular and undifferentiated pattern. Arch Intern Med. 1985;145(8):1507-9.

Pastolero GC, Coire CI, Asa SL. Concurrent medullary and papillary carcinomas of thyroid with lymph node metastases. A collision phenomenon. Am J Surg Pathol. 1996 Feb;20(2):245-50.

Sobrinho-Simoes M. Mixed medullary and follicular carcinoma of the thyroid. Histopathol. 1993;23(3):287-9.

Pfaltz M, Hedinger CE, Muhlethaler JP. Mixed medullary and follicular carcinoma of the thyroid. Virchows Arch A Pathol Anat Histopathhol. 1983;400(1):53-9.

Gonzalez-Campora R, Lopez-Garrido J, Martin-Lacave I, Miralles-Sanchez EJ, Villar JL. Concurrence of a symptomatic encapsulated follicular carcinoma, an occult papillary carcinoma and a medullary carcinoma in the same patient. Histopathol. 1992;21(4):380-2.

Apel RL, Alpert LC, Rizzo A, LiVolsi VA, Asa SL. A metastasizing composite carcinoma of the thyroid with distinct medullary and papillary components. Arch Pathol Lab Med. 1994 Nov;118(11):1143-7.

Albores-Savedra J, de la Mora TG, de la Torre-Rendon F, Gould E. Mixed Medullary-papillary carcinoma of the thyroid: a previously unrecognized variant of thyroid carcinoma. Hum Pathol. 1990 Nov;21(11):1151-5.

Lax SF, Beham A, Kronberger-Schonecker D, Langsteger W, Denk H. Coexistence of papillary and medullary carcinoma of the thyroid gland-mixed or collision tumor? Clinicopathological analysis of three cases. Virchows Arch. 1994;424(4):441-7.

Hasney CP, Amedee RG. Mixed medullary-papillary carcinoma of the thyroid: a case report. Laryngoscope. 2010;120(S4):153.

Nangue C, Bron L, Portmann L, Volante M, Ris HB, Monnier P, et al. Mixed medullary-papillary carcinoma of the thyroid: report of a case and review of the literature. Head Neck. 2009;31(7):968-74.

Goyal R, Nada R, Rao KL, Radotra BD. Mixed medullary and follicular cell carcinoma of the thyroid with lymph node metastasis in a 7-year-old child. Pathol Int. 2005;56(2):84-8.

Papotti M, Negro F, Carney JA, Bussolati G, Lioyd RV. Mixed medullary-follicular carcinoma of the thyroid. A morphological, immunohistochemical and in situ hybridization analysis of 11 cases. Virchows Arch. 1997:430(5):397-405.

NakazawaT, Cameselle-Teijeiro J, Vinagre J, Soares P, Rousseau E, Eloy C, et al. Carcinoma of the thyroid: the diagnostic importance of CGRP immunoreactivity. C cell-derived calcitonin-free neuroendocrine. Int J Surg Pathol. 2014;22(6):530-5.