DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20194964

Cervical lymphadenopathy as initial presentation of genito-urinary cancer

Sasanka K. Barua, Sarbartha K. Pratihar, Pranab K. Kaman, Atul Garg, Rajeev T. P., Saumar J. Baruah, Puskal K. Bagchi, Debanga Sarma, Mandeep Phukan

Abstract


Head and neck cancers rank fifth amongst the most affected cancers in the world. Metastasis to cervical lymph nodes is primarily from sites in head and neck. About 1% of all malignant cervical adenopathies are encountered as metastasis from remote primary site. We present here our experience of four cases in last five years. Patients presented as cervical lymphadenopathy with unknown primary, which on evaluation was found to be of genitourinary source from different sites. It is a single centre retrospective study. We reviewed cancer registry. We found four cases of genitourinary cancer with cervical lymph node metastasis. Patients presented as cervical lymphadenopathy of unknown primary. Among those one papillary renal cell cancer with rhabdoid differentiation, one testicular cancer, two prostate cancer. One case was a 67 year male patient, who revealed papillary renal cell carcinoma with rhabdoid features. Another patient was a male of 31 years, who had left testicular mass with retroperitoneal and cervical lymphadenopathy. Two patients of 68 year and 74 year respectively had metastatic prostate cancer. All patients underwent proper treatment and regularly followed up. Although rare, malignant cervical lymphadenopathy may be the first clinical manifestation of metastasis from genitourinary tumors. Evaluation of genitourinary system must be included in the protocol for uncovering the primary tumor site in cases of isolated cervical adenopathy.

 


Keywords


Genitourinary cancer with cervical lymph node metastasis, Cervical lymphadenopathy with unknown primary, Papillary renal cell carcinoma with rhabdoid differentiation, Testicular cancer, Prostate cancer

Full Text:

PDF

References


Sankaranarayanan R, Masuyer E, Swaminathan R. Head and neck cancer: a global perspective on epidemiology and prognosis.Anticancer Res. 1998;18(6B):4779-86.

López F, Rodrigo JP, Silver CE, Haigentz M, Bishop JA, Strojan P, et al. Cervical lymph node metastases from remote primary tumor sites. Head Neck. 2016;38.

Hessan H, Strauss M, Sharkey FE. Urogenital tract carcinoma metastatic to the head and neck. Laryngoscope. 1986;96(12):1352-6.

Jones H, Anthony PP. Metastatic prostatic carcinoma presenting as left-sided cervical lymphadenopathy: a series of 11 cases. Histopathology. 1992;21(2):149-54.

Pritchyk KM, Schiff BA, Newkirk KA. Metastatic renal cell carcinoma to the head and neck. Laryngoscope. 2002;112(9):1598-602.

Berkiten G, Kumral TL, Yildirim G, Atar Y, Salturk Z, Dogan MO, et al. Metastasis of Renal Cell Carcinoma to the Head and Neck Region. Otolaryngol Online J. 2016;6:3.

[7] Lieder A, Guenzel T, Lebentrau S, Schneider C, Franzen A. Diagnostic relevance of metastatic renal cell carcinoma in the head and neck: An evaluation of 22 cases in 671 patients. Int Braz J Urol. 2017;43(2):202–8.

Pritchyk KM, Schiff BA, Newkirk KA, Krowiak E, Deeb ZE. Metastatic renal cell carcinoma to the head and neck. Laryngoscope. 2002;112:1598–1602.

Boles R, Cerny J. Head and neck metastases from renal carcinomas. Mich Med. 1971;70:616–8.

Batson OV. The function of the vertebral veins and their role in the spread of metastases. Ann Surg. 1940;112:138–49.

Gottlieb MD, Roland JT.Paradoxical spread of the renal cell carcinoma to the head and neck. Laryngoscope. 1998;108:1301–5.

Vledder MG, Hage JA, Kirkels WJ. Cervical lymph node dissection for metastatic testicular cancer. Ann Surg Oncol. 2010;17(6):1682-7.

See WA, Laurenzo JF, Dreicer R, Hoffman HT. Incidence and management of testicular carcinoma metastatic to the neck. J Urol. 1996;155:590–2.

Geethamala K, Sharanappa A, Kittur SK. Cytological diagnosis of bilateral supraclavicular swellings-Be aware of the rare. Clin Cancer Investig J. 2018;7:231-3.

Hematpour K, Bennett CJ, Rogers D, Head CS. Supraclavicular lymph node: incidence of unsuspected metastatic prostate cancer. Eur Arch Otorhinolaryngol. 2006;263:872–4.

Flocks RH, Boatman DL. Incidence of head and neck metastases of from genito-urinary neoplasms.Laryngoscope. 1973;83:1527–39.

Lin YY, Lin DS, Kang BH, Lin YS. Neck mass as the first presentation of metastatic prostatic adenocarcinoma. J Chin Med Assoc. 2011;74:570–3.

Srivastava P, Srivastava S, Kumar S. Cervical Lymph Nodes in CA Prostate: An Easiest Tool to Deal with Diagnostic Dilemma. J Neoplasm. 2018;3(1):3.