Published: 2019-10-23

Out-of-the-box soft tissue tumor: pediatric synovial sarcoma of larynx

Albert Alhatem, Nicole Farber, Soly Baredes, Neena Mirani


Synovial sarcoma (SS) is a very rare, aggressive, mesenchymal neoplasm that displays both spindle cell and epithelial histologic characteristics. To our knowledge, there are only 20 documented cases of primary laryngeal SS in the English language literature among all age groups and only three case reports among the pediatric population. Due to its rarity, recognition of this laryngeal neoplasm is often very difficult, and diagnosis relies heavily on immunohistochemistry and its unique translocation between chromosome X and 18 [t(X; 18) (p11.2; q11.2)]. The treatment of SS typically involves a multimodal approach with surgery, chemotherapy, and radiation but despite these options the prognosis remains poor.Here we report the fourth laryngeal SS pediatric patient along with a review of all SS published cases in children. The current report is not only presenting the youngest patient with laryngeal SS but also the pediatric patient with the longest survival.


Synovial sarcoma, Larynx, Pediatric pathology, Translocation (X; 18)

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Madabhavi I, Bhardawa V, Modi M, Patel A, Sarkar M. Primary synovial sarcoma (SS) of larynx. An unusual site. Oral Oncol. 2018;79:80-2.

Simon DPC, MacGregor FB. Laryngeal synovial cell sarcoma in an 11 year old boy. Challenges of management and rehabilitation. Int J Pediatr Otorhinolaryngol Extra. 2012;7:97-9.

Sato T, Hasegawa H, Sugasawa M, Yasuda M, Morita K, Nakahira M, et al. Free jejunal transfer for a 15-year-old girl with synovial sarcoma of the hypopharynx. J Plast Reconstr Aesthet Surg. 2011;64:1100-3.

Saxby C, Bova R, Edwards M. Laryngeal synovial sarcoma: a rare clinical entity. Case Rep Otolaryngol. 2013;2013:578606.

Morland B, Cox G, Randall C, Ramsay A, Radford M. Synovial sarcoma of the larynx in a child: case report and histological appearances. Med Pediatr Oncol. 1994;23:64-8.

Javed N, Iqbal J. Synovial sarcoma of the larynx. J Ayub Med Coll Abbottabad. 2015;27:729-30.

Fisher C. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401-21.

Mohammadi G, Khansarinia A. Synovial sarcoma- a rare tumor of the larynx. Iran J Otorhinolaryngol. 2016;28:233-6.

Boniver V, Moreau P, Lefebvre P. Synovial sarcoma of the larynx. case report and literature review. B-ENT. 2005;1:47-51.

Gorenstein A, Neel HB, Weiland LH, Devine KD. Sarcomas of the larynx. Arch Otolaryngol. 1980;106:8-12.

Sturgis EM, Potter BO. Sarcomas of the head and neck region. Curr Opin Oncol. 2003;15:239-52.

Skytting B. Synovial sarcoma. A Scandinavian Sarcoma Group project. Acta Orthop Scand. 2000;291:1-28.