A prospective analysis of vitamin D and recurrent benign paroxysmal positional vertigo


  • N. Gopinathan Pillai Department of ENT, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India
  • Induvarsha Gopinath Department of ENT, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India




Benign paroxysmal positional vertigo, Vitamin D, Calcium, Recurrence


Background: The aim of the present study was to prospectively evaluate the role of vitamin D in the recurrence of Benign paroxysmal positional vertigo (BPPV). The BPPV is one of the commonest causes for peripheral vertigo. Many studies stated that BPPV can be associated with many co-morbidities and vitamin deficiencies.

Methods: In our study, we prospectively conducted an observational study in patients suffering from BPPV, from a study period of June 2015 to June 2018, to evaluate the role of vitamin D and calcium in those patients.

Results: Three forty eight patients between the age group of 40 to 82 years, suffering from BPPV were included in the study. It includes 235 females and 113 male patients. Out of these 108 patients had noticed vitamin D deficiency and were randomly divided into 2 groups in which group A received Vitamin D supplementation and Group B did not received vitamin D supplements. Calcium levels were found to be less in 15 patients between 7 and 10.5 mg/dl, however a larger sample is required for its correlation. All patients were followed up for 1 year.

Conclusions: The study showed a significant decrease of BPPV in those who received vitamin D supplementation.


Al-Asadi J, Al-Lami Q. Prevalence and risk factors of benign paroxysmal positional vertigo among patients with dizziness. Br J Med Medical Res. 2015;7(9)754-61.

De Stefano A, Dispensa F, Suarez H, Perez-Fernandez N, Manrique-Huarte R, Ban JH, et al A multicentre observational study on the role of co-morbidities in the recurrent episodes of benign paroxismel positional vertigo. Auris Nasus Larynx. 2014;14:31-6.

Bhatacharyya N, Gubbels SP, Schwtatz SR, Edlow J, El-Kashlan H, Fife T, et al. Clinical practice guideloine.Benign Paroxysmal positional vertigo(Update). Otolaryngol Head Neck Surg. 2017;156(3S):1-47.

Buki B, Ecker M, Junger H, Lundberg YW. Vitamin D deficiency and benign paroxysmal positional vertigo. Medical Hypotheses. 2013;80(2):201-4.

Halmagyi GM, Thurtell MJ, Curthoys IS. Vertigo: clinical syndromes. In: Gleeson M, ed. Scott-Browns Otorhinolaryngology, Head and Neck Surgery. 7ed. London, UK: Taylor and Francis Ltd; 2008: 3760-3763.

Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrisons Principles of Internal Medicines. United States: McGraw Hill; 2018.

Hotson JR, Baloh RW. Acute vestibular syndrome. N Engl J Med. 1998;339(10):680-5.

Jang Y, Hwang C, Shin J, Bae W, Kim L. Age related changes on the morphology of the otoconia. Thelaryncoscope. 2006:996-1001.

Karatas A, Yuceant GA, Yuce T, Haci C, CebiI T, Salviz M. Association of benign paroxysmal positional vertigo with osteoporosis and vitamin D deficiency. J Int Advan Otol. 2017;13(2):259-65.

Lundberg Y, Xu Y, Thiessen K, Kramer K. Mechanism of otoconia and otolith development. Develop Dynamics. 2014;244(3):239-53.

Parham K, Leonard G, Feinn R, Lafereniere D, Kenny A. Prospective clinical investigation of the relationship between idiopathic benign paroxysmal positional vertigo and bone turnover. Laryngoscope. 2013;123(11):2834-9.

Picciotti PM, Lucidi D, Corso ED, Meucci D, Sergi B, Plaudetti G. Co-morbidities and recurrence of benign paroxysmal vertigo. Int J Audiol. 2016;55(5):279-84.

Schuknecht H. Cupulolithiasis: Archives of Otolaryngology-Head and Neck Surgery. 1969;90(6):765-78.

Jeong SH, Kim JS, Shin JW, Kim S, Lee H, Lee AY, et al. Decreased serum vitamin D in idiopathic benign paroxysmal position vertigo. J Neurol. 2012;260(3):832-8.

Talaat HS, Kabel AM, Khaliel LH, Abuhadied G, El-Naga HA, Talaat AS. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx. 2016;43(3):237-41.

Waringhoff JC, Bayer O, Ferrari U, Straube A. Co-morbidities of vertiginous disease. BMC Neurol. 2009;9:29.






Original Research Articles